Reversal of Ethanol-Seeking Behavior by D1 and D2 Antagonists in an Animal Model of Relapse: Differences in Antagonist Potency in Previously Ethanol-Dependent versus Nondependent Rats

A Neural Substrate of Prediction and Reward

1997 • 8,991 citations

Drugs of abuse: anatomy, pharmacology and function of reward pathways

1992 • 2,091 citations

Neurobehavioural mechanisms of reward and motivation

1996 • 1,177 citations

Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol.

1986 • 852 citations

Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area

1985 • 788 citations

Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.

1993 • 741 citations

Conditioning factors in drug abuse: can they explain compulsion?

1998 • 680 citations

Initiation of Ethanol Reinforcement using a Sucrose‐Substitution Procedure in Food‐ and Water‐Sated Rats

1986 • 668 citations

Ethanol Self-Administration Restores Withdrawal-Associated Deficiencies in Accumbal Dopamine and 5-Hydroxytryptamine Release in Dependent Rats

1996 • 455 citations

Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.

1997 • 430 citations

Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens

2000 • 412 citations

Ethanol Directly Excites Dopaminergic Ventral Tegmental Area Reward Neurons

1999 • 390 citations

Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.

1997 • 374 citations

Differential Influence of Associative and Nonassociative Learning Mechanisms on the Responsiveness of Prefrontal and Accumbal Dopamine Transmission to Food Stimuli in Rats FedAd Libitum

1997 • 374 citations

Suppression of Ethanol-Reinforced Behavior by Naltrexone Is Associated with Attenuation of the Ethanol-Induced Increase in Dialysate Dopamine Levels in the Nucleus Accumbens

1998 • 362 citations

Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: Reversal by D ₁ antagonists

2001 • 357 citations

"Craving" and Relapse to Drink

1974 • 319 citations

Dopamine D1-like Receptors and Reward-related Incentive Learning

1998 • 295 citations

Modulation of feeding‐induced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state

1999 • 276 citations

Reinstatement of Alcohol-Seeking Behavior by Drug-Associated Discriminative Stimuli after Prolonged Extinction in the Rat

1999 • 224 citations

Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior

2001 • 218 citations

Long-term ethanol administration methods for rats: advantages of inhalation over intubation or liquid diets

1979 • 210 citations

Enduring Resistance to Extinction of Cocaine-Seeking Behavior Induced by Drug-Related Cues

2001 • 203 citations

Time-dependent quantifiable withdrawal from ethanol in the rat: Effect of method of dependence induction

1996 • 168 citations

Reactivity to alcohol-related cues: physiological and subjective responses in alcoholics and nonproblem drinkers.

1985 • 163 citations

Mesolimbic dopaminergic reduction outlasts ethanol withdrawal syndrome: Evidence of protracted abstinence

1996 • 131 citations

Ethanol, like psychostimulants and morphine, causes long-lasting hyperreactivity of dopamine and acetylcholine neurons of rat nucleus accumbens: possible role in behavioural sensitization

1997 • 129 citations

Locomotion and conditioned place preference produced by acute intravenous amphetamine: role of dopamine receptors and individual differences in amphetamine self-administration

1999 • 117 citations

Long-Lasting Resistance to Extinction of Response Reinstatement Induced by Ethanol-Related Stimuli: Role of Genetic Ethanol Preference

2001 • 106 citations

Peripheral and intraamygdalar administration of the dopamine D-sub-1 receptor antagonist SCH 23390 blocks fear-potentiated startle but not shock reactivity or the shock sensitization of acoustic startle.

2000 • 104 citations

Long‐Lasting Resistance to Extinction of Response Reinstatement Induced by Ethanol‐Related Stimuli: Role of Genetic Ethanol Preference

2001 • 99 citations

Effects of dopamine agonists and antagonists on cocaine-induced operant responding for a cocaine-associated stimulus

1996 • 94 citations

Peripheral and intraamygdalar administration of the dopamine D₁ receptor antagonist SCH 23390 blocks fear-potentiated startle but not shock reactivity or the shock sensitization of acoustic startle.

2000 • 91 citations

Effects of typical and atypical antipsychotic drugs on freezing behavior induced by conditioned fear

1996 • 83 citations

Dopamine Metabolism and Receptor Function After Acute and Chronic Ethanol

1980 • 82 citations

Nicotine-conditioned locomotor activity in rats: dopaminergic and GABAergic influences on conditioned expression

2001 • 79 citations

D1 but not D2 dopamine receptor antagonism blocks the acquisition of a flavor preference conditioned by intragastric carbohydrate infusions

2001 • 71 citations

Ethanol anticipation enhances dopamine efflux in the nucleus accumbens of alcohol-preferring (P) but not Wistar rats

1996 • 64 citations

Haloperidol does not alter expression of ethanol-induced conditioned place preference

1992 • 50 citations

Unrestricted free-choice ethanol self-administration in rats causes long-term neuroadaptations in the nucleus accumbens and caudate putamen

1999 • 49 citations

The effect of chronic ethanol administration on central neurotransmitter mechanisms.

1979 • 40 citations

Manipulation of operant responding for an ethanol-paired conditioned stimulus in the rat by pharmacological alteration of the serotonergic system

2000 • 40 citations

Dopamine Release During Ethanol Drinking in AA Rats

1998 • 33 citations

Dopaminergic and opiate agonists and antagonists differentially decrease multiple schedule responding maintained by sucrose/ethanol and sucrose

1997 • 29 citations

Differential effects of dopamine receptor subtype blockade on performance of rats in a reaction-time paradigm

2000 • 28 citations

Hormones and the brain

1982 • 2 citations