Cloned cytotoxic T lymphocyte target cells fail to induce early activation events in effector cytotoxic T lymphocytes

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Distinct populations of microtubules: Tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo

1984 • 532 citations

Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells.

1982 • 283 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

The events of primary T cell activation can be staged by use of Sepharose-bound anti-T3 (64.1) monoclonal antibody and purified interleukin 1.

1985 • 189 citations

Isolation and characterization of a serine esterase from cytolytic T cell granules

1986 • 177 citations

Lymphokine‐Driven “Differentiation” of Cytotoxic T‐Cell Clones into Cells with NK‐Like Specificity: Correlations with Display of Membrane Macromolecules

1983 • 158 citations

Antigen receptor-triggered secretion of a trypsin-type esterase from cytotoxic T lymphocytes.

1987 • 109 citations

Antigen-dependent increase in cytosolic free calcium in specific human T-lymphocyte clones

1985 • 92 citations

The area of attachment of cytotoxic T lymphocytes to their target cells shows high motility and polarization of actin, but not myosin.

1982 • 90 citations

Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes.

1986 • 89 citations

Resistance of cloned cytotoxic T lymphocytes to cell-mediated cytotoxicity.

1987 • 89 citations

Investigation of early T cell activation: Analysis of the effect of specific antigen, interleukin 2 and monoclonal antibodies on intracellular free calcium concentration

1985 • 88 citations

Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets.

1987 • 86 citations

T-lymphocyte-mediated cytolysis as an excitatory process of the target

1985 • 71 citations

Sensitivity of cytotoxic T cells to T-cell mediated cytotoxicity

1974 • 70 citations

Antigen-specific T cell activation results in an increase in cytoplasmic free calcium.

1985 • 66 citations

The role of Ca2+ in activation of mature cytotoxic T lymphocytes for lysis.

1987 • 49 citations

Demonstration of a calcium influx in cytolytic T lymphocytes in response to target cell binding.

1987 • 48 citations

The most efficient cytotoxic T lymphocytes are the least susceptible to lysis.

1987 • 41 citations

T Lymphocyte-Mediated Cytolysis: Dissociation of the Binding and Lytic Mechanisms of the Effector Cell

1978 • 40 citations

Duration of the calcium signal in the mitogenic stimulation of thymocytes

1983 • 35 citations

Early events during the activation of human lymphocytes by the mitogenic monoclonal antibody OKT3

1984 • 17 citations