Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood

1984 • 1,345 citations

Neurosteroids and GABAA receptor function

1995 • 705 citations

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

1996 • 569 citations

Dichlorophenyl phosphoramidates as substrates for avian and mammalian liver phosphotriesterases: activity levels, calcium dependence and stereospecificity

1999 • 547 citations

Chemoprotection against cancer by Phase 2 enzyme induction

1995 • 454 citations

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

1992 • 442 citations

Tea in chemoprevention of cancer

1996 • 388 citations

A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency

1995 • 358 citations

The Effects of Oral Dehydroepiandrosterone on Endocrine-Metabolic Parameters in Postmenopausal Women*

1990 • 315 citations

Rat brain phenolsulfotransferase—partial purification and some properties

1973 • 314 citations

Neurosteroids

1994 • 310 citations

A cluster of sulfatase genes on Xp22.3: Mutations in chondrodysplasia punctata (CDPX) and implications for warfarin embryopathy

1995 • 307 citations

Conjugation Reactions in Drug Metabolism

1991 • 253 citations

Green tea consumption and the risk of pancreatic and colorectal cancers

1997 • 231 citations

Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase

1995 • 223 citations

Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential

1994 • 218 citations

Cloning and Expression of Human Arylsulfatase A

1989 • 214 citations

Tea and cancer prevention: An evaluation of the epidemiologic literature

1997 • 213 citations

Bioactivation of mutagens via sulfation

1997 • 204 citations

Bioavailability of the dietary antioxidant flavonol quercetin in man

1997 • 201 citations

Steroid sulfation by expressed human cytosolic sulfotransferases

1994 • 175 citations

Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver.

1983 • 167 citations

Molecular enzymology of human liver cytosolic sulfotransferases

1991 • 157 citations

Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s).

1995 • 149 citations

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION: Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat

1996 • 141 citations

Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity

1994 • 140 citations

Multiple forms of phenolsulphotransferase in human tissues

1982 • 140 citations

Human Liver Estrogen Sulfotransferase: Identification by cDNA Cloning and Expression

1994 • 139 citations

Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability.

1988 • 138 citations

Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase.

1993 • 138 citations

Phylogenetic conservation of arylsulfatases. cDNA cloning and expression of human arylsulfatase B.

1990 • 135 citations

Defect in 3'-phosphoadenosine 5'-phosphosulfate formation in brachymorphic mice.

1979 • 122 citations

Quercetin in our diet: From potent mutagen to probable anticarcinogen

1994 • 118 citations

Cloning and expression of human liver dehydroepiandrosterone sulphotransferase

1993 • 117 citations

Isolation and expression of a cDNA encoding a male-specific rat sulfotransferase that catalyzes activation of N-hydroxy-2-acetylaminofluorene.

1993 • 117 citations

Human Sulfotransferase SULT1C1: cDNA Cloning, Tissue-Specific Expression, and Chromosomal Localization1

1997 • 114 citations

Cloning and Expression of Human Steroid-sulfatase

1989 • 110 citations

Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes.

1994 • 109 citations

Biosynthesis and assay of neurosteroids in rats and mice: Functional correlates

1995 • 109 citations

Low-fat, high-fiber diet and serum estrone sulfate in premenopausal women

1989 • 101 citations

Experimental evidence for cancer preventive elements in foods

1997 • 97 citations

Increased Cholesterol Sulfate and Cholesterol Sulfotransferase Activity in Relation to the Multi-step Process of Differentiation in Human Epidermal Keratinocytes

1989 • 92 citations

Steroid sulfatase deficiency and x-linked ichthyosis

1979 • 92 citations

Regulation of Steroid Hormone Action in Target Cells by Specific Hormone-Inactivating Enzymes

1992 • 89 citations

Identification of Two Human Brain Aryl Sulfotransferase cDNAs

1993 • 88 citations

Human Liver Thermolabile Phenol Sulfotransferase: cDNA Cloning, Expression and Characterization

1994 • 88 citations

Defect in 3′-phosphoadenosine 5′-phosphosulfate synthesis in brachymorphic mice

1982 • 87 citations

Conjugation-deconjugation reactions in drug metabolism and toxicity

1995 • 86 citations

Regulation of estrogen sulfotransferase in human endometrial adenocarcinoma cells by progesterone.

1996 • 85 citations

Tea polyphenols as inhibitors of mutagenicity of major classes of carcinogens

1996 • 84 citations

Quercetin, a potent and specific inhibitor of the human P-form phenolsulfotransferase

1995 • 82 citations

Clinical spectrum of steroid sulfatase deficiency: X-linked recessive ichthyosis, birth complications and cryptorchidism

1983 • 82 citations

Human Platelet Phenolsulfotransferases: cDNA Cloning, Stable Expression in V79 Cells, and Identification of a Novel Allelic Variant of the Phenol-Sulfating Form

1995 • 79 citations

Activation of 2‐Hydroxyamino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridne by cDNA‐expressed Human and Rat Arylsulfotransferases

1994 • 76 citations

Human intestinal phenol sulfotransferase: assay conditions, activity levels and partial purification of the thermolabile form.

1989 • 73 citations

Induction of Estrogen Sulfotransferase in the Human Endometrium by Progesterone in Organ Culture*

1982 • 72 citations

Sulfonation in chemical carcinogenesis — history and present status

1994 • 71 citations

Molecular Characterization of a Human Aryl Sulfotransferase cDNA

1993 • 69 citations

Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase: immunochemical characterization of individual variation.

1996 • 68 citations

cDNA Cloning and expression of a new form of human aryl sulfotransferase

1996 • 68 citations

Metabolism of estradiol-17β in human endometrium during the menstrual cycle

1975 • 68 citations

The Evolutionary Conservation of a Novel Protein Modification, the Conversion of Cysteine to Serinesemialdehyde in Arylsulfatase from Volvox carteri

1996 • 67 citations

Primary structures and properties of two related forms of aryl sulfotransferases in human liver

1995 • 66 citations

Active Site Directed Inhibition of Estrone Sulfatase by Nonsteroidal Coumarin Sulfamates

1996 • 66 citations

Validation and use of cloned, expressed human drug-metabolizing enzymes in heterologous cells for analysis of drug metabolism and drug-drug interactions

1993 • 64 citations

Rat Chondrosarcoma ATP Sulfurylase and Adenosine 5'-Phosphosulfate Kinase Reside on a Single Bifunctional Protein

1994 • 62 citations

Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies

1994 • 61 citations

Human liver dehydroepiandrosterone sulfotransferase: Nature and extent of individual variation

1993 • 60 citations

Inhibition of PhIP mutagenicity by catechins, and by theaflavins and gallate esters

1997 • 58 citations

Common food additives are potent inhibitors of human liver 17α-ethinyloestradiol and dopamine sulphotransferases

1993 • 57 citations

Characterization of a cluster of sulfatase genes on Xp22.3 suggests gene duplications in an ancestral pseudoautosomal region

1996 • 57 citations

Purification, Characterization, and Molecular Cloning of A Novel Rat Liver Dopa/Tyrosine Sulfotransferase

1995 • 57 citations

Increase in cholesterol sulfotransferase activity during in vitro squamous differentiation of rabbit tracheal epithelial cells and its inhibition by retinoic acid.

1987 • 56 citations

A clinical and genetic study of X-linked recessive ichthyosis and contiguous gene defects

1994 • 55 citations

Acetaminophen decreases adenosine 3'-phosphate 5'-phosphosulfate and uridine diphosphoglucuronic acid in rat liver.

1985 • 55 citations

Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil

1993 • 55 citations

In vitro inhibition of phenolsulphotransferase by food and drink constituents

1987 • 55 citations

Defect in 3′-phosphoadenosine 5′-phosphosulfate synthesis in brachymorphic mice

1982 • 54 citations

Differential Distribution of Phenol and Catechol Sulphotransferases in Human Liver and Intestinal Mucosa

1990 • 54 citations

Sulfotransferase pharmacogenetics

1990 • 54 citations

Sulphation catalysed by the human cytosolic sulphotransferases - chemical defence or molecular terrorism?

1996 • 52 citations

In vivo activity of 4-methylcoumarin-7-O-sulfamate, a nonsteroidal, nonestrogenic steroid sulfatase inhibitor.

1996 • 52 citations

Memory enhancement mediated by the steroid sulfatase inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine

1996 • 50 citations

Inhibition of placental estrone sulfatase activity and MCF-7 breast cancer cell proliferation by estrone-3-amino derivatives

1996 • 50 citations

STEROID SULFATASE IN BRAIN: COMPARISON OF SULFOHYDROLASE ACTIVITIES FOR VARIOUS STEROID SULFATES IN NORMAL AND PATHOLOGICAL BRAINS, INCLUDING THE VARIOUS FORMS OF METACHROMATIC LEUKODYSTROPHY

1976 • 49 citations

Review: Placental sulphatase deficiency

1982 • 47 citations

An evaluation of methods to decrease the availability of inorganic sulphate for sulphate conjugation in the rat in vivo

1981 • 47 citations

Sulfation pharmacogenetics in humans

1994 • 46 citations

Ellagic acid induces transcription of the rat glutathione S-transferase-Ya gene

1995 • 44 citations

Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme

1995 • 43 citations

Activation of benzylic alcohols to mutagens by rat and human sulfotransferases expressed in Escherichia coli

1995 • 42 citations

Desulfation of 3,5,3′-Triiodothyronine Sulfate by Microsomes from Human and Rat Tissues*

1988 • 42 citations

Sulfation of aromatic hydroxamic acids and hydroxylamines by multiple forms of human liver sulfotransferases

1994 • 40 citations

Human dehydroepiandrosterone sulfotransferase pharmacogenetics: Quantitative Western analysis and gene sequence polymorphisms

1996 • 40 citations

Differential expression and immunohistochemical localisation of the phenol and hydroxysteroid sulphotransferase enzyme families in the developing lung

1996 • 39 citations

Intermediate Channeling between ATP Sulfurylase and Adenosine 5'-Phosphosulfate Kinase from Rat Chondrosarcoma

1994 • 39 citations

Identification and Partial Purification of PAPS Translocase

1996 • 39 citations

Design, production and characterization of antibodies discriminating between the phenol-and monoamine-sulphating forms of human phenol sulphotransferase

1996 • 38 citations

The fetoplacental unit of primates^*

2009 • 36 citations

Red wine contains a potent inhibitor of phenolsulphotransferase.

1985 • 36 citations

Ellagic acid induces NAD(P)H:quinone reductase through activation of the antioxidant responsive element of the rat NAD(P)H:quinone reductase gene

1994 • 34 citations

Characterization of the promoter region of human steriod sulfatase: A gene which escapes X inactivation

1996 • 33 citations

Studies on the biological activity of triiodothyronine sulfate.

1992 • 33 citations

Kinetics of PAPS Translocase: Evidence for an Antiport Mechanism

1996 • 32 citations

Enhancement of rat hepatic and gastrointestinal glutathione and glutathione S-transferases by α-angelicalactone and flavone

1995 • 32 citations

Activation of promutagens by endogenous and heterologous sulfotransferases expressed in continuous cell cultures

1994 • 31 citations

Dietary Ellagic Acid Inhibits the Enzymatic Activity of CYP1A1 without Altering Hepatic Concentrations of CYP1A1 or CYP1A1 mRNA

1994 • 30 citations

Recent studies on the metabolic activation of chemical carcinogens.

1994 • 30 citations

Plasma free and conjugated catecholamines in clinical disorders

1986 • 30 citations

Sulfate-Activating Enzymes in Normal and Brachymorphic Mice: Evidence for a Channeling Defect

1995 • 28 citations

Evidence for (+)-cicletanine sulfate as an active natriuretic metabolite of cicletanine in the rat

1995 • 28 citations

Testis cancer. Ichthyosis constitutes a significant risk factor

1991 • 27 citations

Improved bacterial expression of the human P form phenolsulfotransferase. Applications to drug metabolism.

1996 • 27 citations

Low Maternal Serum Unconjugated Estriol During Prenatal Screening as an Indication of Placental Steroid Sulfatase Deficiency and X-Linked Ichthyosis

1995 • 26 citations

Salmonella strains and mammalian cells genetically engineered for expression of sulfotransferases

1995 • 26 citations

Uptake of sulfate conjugates by isolated rat hepatocytes.

1996 • 25 citations

Estrogen and phenol sulfotransferase activities in human fetal lung

1992 • 25 citations

Reduced platelet phenolsulphotransferase activity towards dopamine and 5-hydroxytryptamine in migraine

1995 • 25 citations

Enzymatic regulation of estradiol-17β concentrations in human breast cancer cells

1991 • 24 citations

Molecular Cloning of a Novel Form of Phenol Sulfotransferase from Human Brain Hippocampus

1995 • 24 citations

Depletion of hepatic 3'-phosphoadenosine 5'-phosphosulfate (PAPS) and sulfate in rats by xenobiotics that are sulfated.

1995 • 23 citations

Distribution of free and conjugated catecholamines between plasma, platelets and erythrocytes: different effects of intravenous and oral catecholamine administrations.

1991 • 22 citations

Immunohistochemical localisation of hydroxysteroid sulphotransferase in human breast carcinoma tissue: a preliminary study

1994 • 20 citations

Assessment of rat liver slices as a suitable model system for studying the simultaneous sulphation and glucuronidation of phenolic xenobiotics

1997 • 18 citations

Developmental profiles of arylsulfatases A and B in rat cerebral cortex and spinal cord

1991 • 11 citations

Acetaminophen does not decrease hepatic 3'-phosphoadenosine 5'-phosphosulfate in mice.

1995 • 8 citations

Steroid Sulphatase Deficiency: Identification of Heterozygotes Using Hydrolysis of Dehydroepiandrosterone Sulphate by Peripheral Leucocytes

1996 • 5 citations

Human ileum phenol sulfotransferase

1989 • 4 citations

The inhibitory effect of medroxyprogesterone acetate on steroid sulfatase in human uterine endometrial cancer cells

1996 • 4 citations

Maternal steroid sulfatase deficiency—Cause of high-risk pregnancy?

1994 • 3 citations