The role of infection in acute pancreatitis

A Clinically Based Classification System for Acute Pancreatitis

1993 • 2,752 citations

Bacterial contamination of pancreatic necrosis

1986 • 926 citations

Prognostic factors in acute pancreatitis.

1984 • 718 citations

The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients

1984 • 694 citations

Acute pancreatitis: prognostic value of CT.

1985 • 600 citations

A randomized multicenter clinical trial of antibiotic prophylaxis of septic complications in acute necrotizing pancreatitis with imipenem.

1993 • 504 citations

Early antibiotic treatment in acute necrotising pancreatitis

1995 • 498 citations

Natural course of acute pancreatitis

1997 • 479 citations

Percutaneous CT-guided catheter drainage of infected acute necrotizing pancreatitis: techniques and results.

1998 • 477 citations

Death due to acute pancreatitis

1985 • 474 citations

Controlled Clinical Trial of Selective Decontamination for the Treatment of Severe Acute Pancreatitis

1995 • 459 citations

Endoscopic therapy for organized pancreatic necrosis

1996 • 443 citations

A prospective longitudinal study of observation versus surgical intervention in the management of necrotizing pancreatitis

1991 • 416 citations

Early diagnosis of pancreatic infection by computed tomography-guided aspiration

1987 • 387 citations

A Controlled Trial in Intensive Care Units of Selective Decontamination of the Digestive Tract with Nonabsorbable Antibiotics

1992 • 367 citations

The prevalence of gut translocation in humans

1994 • 366 citations

The Gut Origin Septic States in Blunt Multiple Trauma (ISS = 40) in the ICU

1987 • 352 citations

Necrosectomy and postoperative local lavage in necrotizing pancreatitis

1988 • 318 citations

Human pancreatic tissue concentration of bactericidal antibiotics

1992 • 293 citations

Role of antibiotics in acute pancreatitis: a meta-analysis

1998 • 234 citations

Gabexate mesilate in human acute pancreatitis

1993 • 231 citations

A Prospective Study to Determine the Efficacy of Antibiotics in Acute Pancreatitis

1976 • 231 citations

Evaluation of prophylactic antibiotics in acute pancreatitis

1975 • 218 citations

The role of the gut in the development of sepsis in acute pancreatitis

1991 • 218 citations

Controlled clinical trial of pefloxacin versus imipenem in severe acute pancreatitis

1998 • 209 citations

Early surgical débridement of symptomatic pancreatic necrosis is beneficial irrespective of infection

1992 • 208 citations

Pancreatic infection complicating acute pancreatitis

1993 • 207 citations

A randomised, double blind, multicentre trial of octreotide in moderate to severe acute pancreatitis

1999 • 203 citations

PMN-Elastase in Comparison with CRP, Antiproteases, and LDH as Indicators of Necrosis in Human Acute Pancreatitis

1991 • 201 citations

Antibiotika bei nekrotisierender Pankreatitis: Ergebnisse einer kontrollierten Studie

2008 • 200 citations

CT-guided aspiration of suspected pancreatic infection

1995 • 172 citations

Acute necrotizing pancreatitis: Management by planned, staged pancreatic necrosectomy/debridement and delayed primary wound closure over drains

1991 • 167 citations

Continuous regional arterial infusion of protease inhibitor and antibiotics in acute necrotizing pancreatitis

1996 • 161 citations

Prevention of nosocomial infection in critically ill patients by selective decontamination of the digestive tract

1992 • 157 citations

Pathogenesis of pancreatic sepsis

1993 • 150 citations

A fifteen year experience with open drainage for infected pancreatic necrosis.

1993 • 143 citations

Selective Gut Decontamination Reduces Nosocomial Infections and Length of Stay but Not Mortality or Organ Failure in Surgical Intensive Care Unit Patients

1992 • 140 citations

Behavior of antibiotics during human necrotizing pancreatitis

1994 • 138 citations

The Use of Ampicillin in Acute Pancreatitis

1975 • 131 citations

Pancreatic Necrosis

1993 • 131 citations

The Role of Antibiotic Prophylaxis in Severe Acute Pancreatitis

1997 • 124 citations

Pathogenesis and Prevention of Early Pancreatic Infection in Experimental Acute Necrotizing Pancreatitis

1995 • 123 citations

Antibiotics in acute pancreatitis

1989 • 117 citations

Surgical strategies in the treatment of pancreatic necrosis and infection

1991 • 113 citations

Antibiotic prophylaxis in the initial management of severe acute pancreatitis

1998 • 105 citations

Routes of spread of pathogens into the pancreas in a feline model of acute pancreatitis.

1994 • 99 citations

Surgical strategy and management of infected pancreatic necrosis

1996 • 95 citations

Debridement and closed cavity irrigation for the treatment of pancreatic necrosis

1989 • 86 citations

Bacterial translocation during acute pancreatitis in rats.

1993 • 84 citations

A Fifteen-Year Experience with Open Drainage for Infected Pancreatic Necrosis

1994 • 83 citations

Prognostic importance of gram-negative intestinal colonization preceding pancreatic infection in severe acute pancreatitis

1998 • 81 citations

Bacterial Translocation in the Course of Acute Pancreatitis: Beneficial Role of Nonabsorbable Antibiotics and Lactitol Enemas

1996 • 67 citations

Infected necrosis: morbidity and therapeutic consequences.

1991 • 66 citations

Retroperitoneal and peritoneal drainage and lavage in the treatment of severe necrotizing pancreatitis.

1990 • 65 citations

Differential Prognosis of Gram‐Negative Versus Gram‐Positive Infected and Sterile Pancreatic Necrosis: Results of a Randomized Trial in Patients with Severe Acute Pancreatitis Treated with Adjuvant Selective Decontamination

1997 • 63 citations

Infection and acute pancreatitis

1994 • 63 citations

A critical review of antibiotic prophylaxis in severe acute pancreatitis

1996 • 60 citations

Colonization and translocation of intestinal bacterial flora.

1996 • 53 citations

Operative management of acute pancreatitis: ventral open packing.

1991 • 49 citations

Pathophysiological role of secretory type I and II phospholipase A2 in acute pancreatitis: an experimental study in rats.

1997 • 48 citations

Bacterial regurgitation in experimental pancreatitis

1964 • 47 citations

Natural Course of Acute Pancreatitis

2008 • 45 citations

The protective effect of a reduction in intestinal flora on mortality of acute haemorrhagic pancreatitis in the rat.

1987 • 45 citations

Blood-pancreatic juice barrier to antibiotic excretion

1986 • 42 citations

Therapeutic Effects of Continuous Intraarterial Antibiotic Infusion in Preventing Pancreatic Infection in Experimental Acute Necrotizing Pancreatitis

1996 • 41 citations

Role of bacterial infection in Diet-Induced acute pancreatitis in mice

1992 • 40 citations

Mechanisms of sepsis in acute pancreatitis in opossums

1995 • 40 citations

Effect of different regimens of gut decontamination on bacterial translocation and mortality in experimental acute pancreatitis.

1995 • 38 citations

Laparoscopic Infracolic Approach for Complications of Acute Pancreatitis

1998 • 34 citations

Early antibiotic treatment in acute necrotising pancreatitis

1995 • 30 citations

Prevention of bacterial infection and sepsis in acute severe pancreatitis.

1992 • 29 citations

Protease-Antiprotease Interactions and the Rationale for Therapeutic Protease Inhibitors

1996 • 24 citations

Postinduction bacteremia in experimental acute pancreatitis

1979 • 24 citations

Surgical strategies in acute pancreatitis.

1993 • 21 citations

Cerulein-Induced Acute Pancreatitis in Rats—Does Bacterial Translocation Occur via a Transperitoneal Pathway?

1997 • 21 citations

The Role of Infection in Acute Pancreatitis

1994 • 21 citations

Infected necrosis: morbidity and therapeutic consequences.

1991 • 20 citations

Infections complicating pancreatitis: diagnosing, treating, preventing.

1998 • 19 citations

Human pancreas-specific protein

1996 • 18 citations

Effects of selective decontamination on gram-negative colonisation, infections and development of bacterial resistance in esophageal resection

1990 • 12 citations

Infected bile-induced acute pancreatitis in rabbits

1998 • 10 citations

Role of Antibiotic Prophylaxis in Severe Acute Pancreatitis

1998 • 8 citations