V. Meta-Analysis of the Efficacy of Hormone Replacement Therapy in Treating and Preventing Osteoporosis in Postmenopausal Women

Assessing the quality of reports of randomized clinical trials: Is blinding necessary?

1996 • 17,261 citations

Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women

1998 • 6,250 citations

Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures

1996 • 3,641 citations

Diabetes and Cardiovascular Disease

1999 • 2,718 citations

Design of the Women’s Health Initiative Clinical Trial and Observational Study

1998 • 2,456 citations

Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer

1997 • 2,438 citations

Systematic Reviews: Identifying relevant studies for systematic reviews

1994 • 2,285 citations

Effects of Estrogen Replacement on the Progression of Coronary-Artery Atherosclerosis

2000 • 1,274 citations

Review papers : The statistical basis of meta-analysis

1993 • 1,221 citations

Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease

2000 • 985 citations

LONG-TERM PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS BY ŒSTROGEN

1976 • 946 citations

A Clinical Trial of Estrogen-Replacement Therapy after Ischemic Stroke

2001 • 906 citations

Estrogen Replacement Therapy and Fractures in Older Women

1995 • 834 citations

OUTCOME FOR INFANTS OF VERY LOW BIRTHWEIGHT: SURVEY OF WORLD LITERATURE

1981 • 829 citations

Treatment of Postmenopausal Osteoporosis with Transdermal Estrogen

1992 • 824 citations

PREVENTION OF SPINAL OSTEOPOROSIS IN OOPHORECTOMISED WOMEN

1980 • 705 citations

Quantitative Computed Tomography of Vertebral Spongiosa: A Sensitive Method for Detecting Early Bone Loss After Oophorectomy

1982 • 657 citations

HORMONE REPLACEMENT THERAPY, HEART DISEASE, AND OTHER CONSIDERATIONS

1998 • 597 citations

Effect of Estrogens and Calcium Carbonate on Bone Loss in Postmenopausal Women

1977 • 577 citations

Does Calcium Supplementation Prevent Postmenopausal Bone Loss?

1987 • 528 citations

Hormone Replacement Therapy and Prevention of Nonvertebral Fractures

2001 • 521 citations

Prevention of Bone Loss with Alendronate in Postmenopausal Women under 60 Years of Age

1998 • 493 citations

Hormone Replacement Therapy and Cardiovascular Disease

2001 • 448 citations

The Minimum Effective Dose of Estrogen for Prevention of Postmenopausal Bone Loss

1985 • 399 citations

Prospective trial of oestrogen and calcium in postmenopausal women.

1977 • 379 citations

Outpatient Waiting Time

1963 • 371 citations

Estrogen replacement therapy I: a 10-year prospective study in the relationship to osteoporosis.

1979 • 369 citations

The Comparative Effect on Bone Density, Endometrium, and Lipids of Continuous Hormones as Replacement Therapy (CHART Study)

1996 • 263 citations

Oestrogen Replacement Therapy for Prevention of Osteoporosis after Oophorectomy

1973 • 260 citations

Estrogen treatment of patients with established postmenopausal osteoporosis

1991 • 256 citations

Calcium Supplementation with and without Hormone Replacement Therapy To Prevent Postmenopausal Bone Loss

1994 • 249 citations

17β-Estradiol and Continuous Norethisterone: A Unique Treatment for Established Osteoporosis in Elderly Women

1990 • 248 citations

The Predictive Value of Biochemical Markers of Bone Turnover for Bone Mineral Density in Early Postmenopausal Women Treated with Hormone Replacement or Calcium Supplementation1

1997 • 227 citations

Low-Dose Esterified Estrogen Therapy

1997 • 226 citations

Combination Treatment with Estrogen and Calcitriol in the Prevention of Age-Related Bone Loss

2001 • 214 citations

Hormone Replacement Therapy and the Risk for First Hip Fracture

1990 • 213 citations

Uterine activity in patients with cervical cerclage.

1990 • 205 citations

CALCITONIN FOR PREVENTION OF POSTMENOPAUSAL BONE LOSS

1988 • 203 citations

Effect of progestin therapy on cortical and trabecular bone: Comparison with estrogen

1991 • 193 citations

A Four-Year Randomized Controlled Trial of Hormone Replacement and Bisphosphonate, Alone or in Combination, in Women with Postmenopausal Osteoporosis

1998 • 192 citations

Alendronate and Estrogen–Progestin in the Long-Term Prevention of Bone Loss: Four-Year Results from the Early Postmenopausal Intervention Cohort Study: A Randomized, Controlled Trial

1999 • 190 citations

MYELOMATOUS OSTEOSCLEROSIS AND PERIPHERAL NEUROPATHY

1965 • 188 citations

Comparative Effects of Oestrogen and a Progestogen on Bone Loss in Postmenopausal Women

1978 • 187 citations

Low-dose esterified estrogen therapy: effects on bone, plasma estradiol concentrations, endometrium, and lipid levels. Estratab/Osteoporosis Study Group

1997 • 186 citations

The Economic Cost of Hip Fractures in Community‐Dwelling Older Adults: A Prospective Study

1997 • 180 citations

Reversal of postmenopausal vertebral bone loss by oestrogen and progestogen: a double blind placebo controlled study

1988 • 167 citations

Low-dosage micronized 17ß-estradiol prevents bone loss inpostmenopausal women

1992 • 161 citations

Hormonal replacement therapy reduces forearm fracture incidence in recent postmenopausal women — results of the Danish Osteoporosis Prevention Study

2000 • 159 citations

Combined therapy with estrogen and etidronate has an additive effect on bone mineral density in the hip and vertebrae: Four-year randomized study

1995 • 157 citations

Effects of one-year treatment with estrogens on bone mass, intestinal calcium absorption, and 25-hydroxyvitamin D-1α-hydroxylase reserve in postmenopausal osteoporosis

1988 • 157 citations

Prospective double-blind trial of synthetic steroid (Org OD 14) for preventing postmenopausal osteoporosis.

1980 • 156 citations

TREATMENT OF POST MENOPAUSAL OSTEOPOROSIS. A CONTROLLED THERAPEUTIC TRIAL COMPARING OESTROGEN/GESTAGEN, 1,25‐DIHYDROXY‐VITAMIN D₃ AND CALCIUM

1982 • 136 citations

Fracture protection provided by long-term estrogen treatment

1995 • 135 citations

HRT and exercise: effects on bone density, muscle strength and lipid metabolism. A placebo controlled 2-year prospective trial on two estrogen-progestin regimens in healthy postmenopausal women

1997 • 134 citations

Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials

2001 • 132 citations

Smoking Eliminates the Protective Effect of Oral Estrogens on the Risk for Hip Fracture among Women

1992 • 129 citations

Effect of progestin therapy on cortical and trabecular bone: comparison with estrogen

1991 • 105 citations

Dose-response evaluation of cyclic estrogen/gestagen in postmenopausal women: Placebo-controlled trial of its gynecologic and metabolic actions

1982 • 104 citations

Effect of 1,25‐dihydroxy ‐ vitamin D₃ in itself or combined with hormone treatment in preventing postmenopausal osteoporosis

1981 • 100 citations

Estrogen treatment of patients with established postmenopausal osteoporosis

1991 • 100 citations

Effects of Hormone Replacement Therapy on Bone Mineral Density in Postmenopausal Women With Primary Hyperparathyroidism

2000 • 89 citations

Non-linear increase in vertebral density induced by a synthetic steroid (Org OD 14) in women with established osteoporosis

1991 • 83 citations

A randomized controlled trial of four doses of transdermal estradiol for preventing postmenopausal bone loss

1999 • 76 citations

Low-Dosage Micronized 17β-Estradiol Prevents Bone Loss in Postmenopausal Women

1992 • 75 citations

Cyclical clodronate is effective in preventing postmenopausal bone loss: A comparative study with transcutaneous hormone replacement therapy

1995 • 75 citations

Superior compliance and efficacy of continuous combined oral estrogen-progestogen replacement therapy in postmenopausal women

1995 • 72 citations

Effects of combined low dose of the isoflavone derivative ipriflavone and estrogen replacement on bone mineral density and metabolism in postmenopausal women

1997 • 68 citations

Two new combinations of estrogen and progestogen for prevention of postmenopausal bone loss: Long‐term effects on bone, calcium and lipid metabolism, climacteric symptoms and bleeding

1992 • 66 citations

The Effects of Estrone (Ogen) on Spinal Bone Density of Postmenopausal Women

1991 • 65 citations

Transdermal estradiol in the treatment of postmenopausal bone loss

1989 • 63 citations

Continuous oestrogen-progestogen treatment and bone metabolism in post-menopausal women

1988 • 61 citations

A clinical trial on the effects of a combination of elcatonin (Carbocalcitonin) and conjugated estrogens on vertebral bone mass in early postmenopausal women

1993 • 61 citations

The Usefulness of Bone Turnover in Predicting the Response to Transdermal Estrogen Therapy in Postmenopausal Osteoporosis

1997 • 59 citations

Monofluorophosphate Combined with Hormone Replacement Therapy Induces a Synergistic Effect on Bone Mass by Dissociating Bone Formation and Resorption in Postmenopausal Women: A Randomized Study1

1999 • 54 citations

Prevention of postmenopausal bone loss with minimal uterine bleeding using low dose continuous estrogen/progestin therapy: a 2-year prospective study

1997 • 53 citations

Prevention of early postmenopausal bone loss using low doses of conjugated estrogens and the non-hormonal, bone-active drug ipriflavone

1995 • 50 citations

A systematic review of the skeletal effects of estrogen therapy in postmenopausal women. II. An assessment of treatment effects

1998 • 49 citations

The effect of hormone replacement therapy on postmenopausal bone loss

1992 • 47 citations

Cytokines and T-lymphocyte subsets in healthy post-menopausal women: Estrogen retards bone loss without affecting the release of IL-1 or IL-1ra

1997 • 46 citations

Neuroendocrine and clinical effects of transdermal 17β-estradiol in postmenopausal women

1991 • 41 citations

Vitamin D and HRT: No benefit additional to that of HRT alone in prevention of bone loss in early postmenopausal women. A 2.5-year randomized placebo-controlled study

1997 • 40 citations

Effects on bone mass after eight years of hormonal replacement therapy

1997 • 39 citations

Bone mineral density in surgically postmenopausal women receiving hormonal replacement therapy as assessed by dual photon absorptiometry

1993 • 39 citations

Desogestrel in hormone replacement therapy: long-term effects on bone, calcium and lipid metabolism, climacteric symptoms, and bleeding

1991 • 38 citations

Monitoring estrogen replacement therapy and identifying rapid bone losers with an immunoassay for deoxypyridinoline

1998 • 36 citations

Factors in response to treatment of early postmenopausal bone loss

1981 • 35 citations

Effect of long‐term administration of progestogen on post‐menopausal bone loss: result of a two‐year, controlled randomized study

1993 • 26 citations

Does calcium potentiate the effect of estrogen therapy on postmenopausal bone loss?

1987 • 25 citations

Commentary on the Women's Health Initiative

2000 • 22 citations

Prophylaxis of osteoporosis with calcium, estrogens and/or eelcatonin: comparative longitudinal study of bone mass

1996 • 21 citations

Effects of percutaneous oestradiol versus oral oestrogens on bone density

1994 • 20 citations

Calcitonin and estrogens

1990 • 20 citations

Prevention of post-oophorectomy bone loss with Tibolone

1995 • 19 citations

Nylestriol replacement therapy in postmenopausal women. A three‐year prospective study

1995 • 14 citations

Effects of one-year hormone replacement therapy on peripheral bone mineral content in patients with osteoporotic spine fractures

1990 • 13 citations

Calcitonin and lumbar bone mineral content during oestrogen-progestogen administration in post-menopausal women

1989 • 12 citations

Prospective evaluation of calcium and estrogen administration on bone mass and metabolism after ovariectomy

1995 • 6 citations

Deleted Work

1955 • 0 citations