WHY NEOADJUVANT ANDROGEN DEPRIVATION PRIOR TO RADICAL PROSTATECTOMY IS UNNECESSARY

Prostate-Specific Antigen as a Serum Marker for Adenocarcinoma of the Prostate

1987 • 2,447 citations

Results of Conservative Management of Clinically Localized Prostate Cancer

1994 • 962 citations

Prostate Specific Antigen in the Diagnosis and Treatment of Adenocarcinoma of the Prostate. II. Radical Prostatectomy Treated Patients

1989 • 877 citations

Localized prostate cancer. Relationship of tumor volume to clinical significance for treatment of prostate cancer

1993 • 805 citations

Important Advances in Oncology

1991 • 768 citations

Correlation of pathologic findings with progression after radical retropubic prostatectomy

1993 • 760 citations

Cancer Control and Quality of Life Following Anatomical Radical Retropubic Prostatectomy: Results at 10 Years

1994 • 704 citations

Long-Term (15 Years) Results After Radical Prostatectomy For Clinically Localized (Stage T2c Or Lower) Prostate Cancer

1994 • 703 citations

Prostate Specific Antigen in the Staging of Localized Prostate Cancer: Influence of Tumor Differentiation, Tumor Volume and Benign Hyperplasia

1990 • 625 citations

Prognostic Significance of Positive Surgical Margins in Radical Prostatectomy Specimens

1995 • 565 citations

A Decision Analysis of Alternative Treatment Strategies for Clinically Localized Prostate Cancer

1993 • 563 citations

Serum PSA after anatomic radical prostatectomy. The Johns Hopkins experience after 10 years.

1993 • 563 citations

5-Year Tumor Recurrence Rates After Anatomical Radical Retropubic Prostatectomy For Prostate Cancer

1994 • 539 citations

Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation.

1990 • 485 citations

SERUM PSA AFTER ANATOMIC RADICAL PROSTATECTOMY

1993 • 463 citations

The Incidence and Significance of Detectable Levels of Serum Prostate Specific Antigen After Radical Prostatectomy

1994 • 426 citations

Nerve-Sparing Radical Prostatectomy: Evaluation of Results after 250 Patients

1990 • 411 citations

Effect of radical prostatectomy for prostate cancer on patient quality of life: results from a medicare survey

1995 • 351 citations

Is Tumor Volume an Independent Predictor of Progression Following Radical Prostatectomy? A Multivariate Analysis of 185 Clinical Stage B Adenocarcinomas of the Prostate with 5 Years of Followup

1993 • 347 citations

The Role of Perineural Space Invasion in the Local Spread of Prostatic Adenocarcinoma

1989 • 344 citations

Effects of androgen withdrawal on the stem cell composition of the Shionogi carcinoma.

1990 • 314 citations

Randomized Prospective Study Comparing Radical Prostatectomy Alone Versus Radical Prostatectomy Preceded by Androgen Blockage in Clinical Stage B2 (T2bNxM0) Prostate Cancer

1995 • 310 citations

Positive Surgical Margins at Radical Prostatectomy: Importance of the Apical Dissection

1990 • 293 citations

Important advances in oncology 1994

1994 • 282 citations

Radical Prostatectomy for Clinical Stage T1-2N0M0 Prostatic Adenocarcinoma: Long-Term Results

1990 • 274 citations

Frequency and Location of Extracapsular Extensionand Positive Surgical Margins in Radical Prostatectomy Specimens

1992 • 260 citations

Impact of Radical Prostatectomy in the Management of Clinically Localized Disease

1994 • 241 citations

Prostate Specific Antigen Levels After Radical Prostatectomy in Patients with Organ Confined and Locally Extensive Prostate Cancer

1992 • 232 citations

Analysis of Risk Factors Associated with Prostate Cancer Extension to the Surgical Margin and Pelvic Node Metastasis at Radical Prostatectomy

1993 • 231 citations

Serum prostate specific antigen levels in mice bearing human prostate LNCaP tumors are determined by tumor volume and endocrine and growth factors.

1992 • 228 citations

The Mechanisms and Prognostic Significance of Seminal Vesicle Involvement by Prostate Cancer

1993 • 228 citations

Quality of Life: Radical Prostatectomy Versus Radiation Therapy for Prostate Cancer

1995 • 226 citations

Estrogens in the Treatment of Prostate Cancer

1995 • 190 citations

Biochemical and Pathological Effects of 8 Months of Neoadjuvant Androgen Withdrawal Therapy Before Radical Prostatectomy in Patients with Clinically Confined Prostate Cancer

1996 • 162 citations

Pathologic changes associated with androgen deprivation therapy for prostate cancer

1991 • 161 citations

Neoadjuvant Hormonal Therapy Before Radical Prostatectomy Decreases the Number of Positive Surgical Margins in Stage T2 Prostate Cancer: Interim Results of a Prospective Randomized Trial

1995 • 158 citations

Total Prostatectomy for Clinically Localized Prostatic Cancer: Long-term Results

1989 • 148 citations

Recent results of management of palpable clinically localized prostate cancer

1993 • 143 citations

Clinical and Pathobiological Effects of Neoadjuvant Total Androgen Ablation Therapy on Clinically Localized Prostatic Adenocarcinoma

1994 • 134 citations

A decision analysis of alternative treatment strategies for clinically localized prostate cancer. Prostate Patient Outcomes Research Team

1993 • 133 citations

Effect of Combination Endocrine Therapy (LHRH Agonist and Flutamide) on Normal Prostate and Prostatic Adenocarcinoma

1991 • 129 citations

Treatment Related Sequelae Following External Beam Radiation for Prostate Cancer: A Review With an Update in Patients with Stages T1 And T2 Tumor

1994 • 127 citations

Prostate Specific Antigen in Hormonally Treated Stage D2 Prostate Cancer: Is it always an Accurate Indicator of Disease Status?

1991 • 124 citations

Long-term evaluation of radical prostatectomy as treatment for clinical stage C (T3) prostate cancer

1993 • 124 citations

Control of Prostate Cancer with Radiotherapy: Long-Term Results

1994 • 117 citations

Combined Hormone Control Therapy and Radical Prostatectomy in the Treatment of Selected Cases of Advanced Carcinoma of the Prostate: A Retrospective Study Based Upon 25 Years of Experience

1969 • 111 citations

Downstaging of localized prostate cancer by neoadjuvant therapy with flutamide and lupron: the first controlled and randomized trial.

1993 • 111 citations

A Critique of the Decision Analysis for Clinically Localized Prostate Cancer

1994 • 108 citations

Preoperative Androgen Deprivation Therapy: Artificial Lowering of Serum Prostate Specific Antigen without Downstaging the Tumor

1993 • 107 citations

Usefulness of immunoperoxidase staining with high-molecular-weight cytokeratin in the differential diagnosis of small-acinar lesions of the prostate gland

1990 • 104 citations

Resection Margin Status in Radical Retropubic Prostatectomy Specimens: Relationship to Type of Operation, Tumor Size, Tumor Grade and Local Tumor Extension

1990 • 103 citations

Science behind total androgen blockade: from gene to combination therapy.

1993 • 100 citations

Radical retropubic prostatectomy with reduced morbidity: an anatomic approach.

1988 • 98 citations

Prostate Specific Antigen Values after Radical Retropubic Prostatectomy for Adenocarcinoma of the Prostate: Impact of Adjuvant Treatment (Hormonal and Radiation)

1991 • 96 citations

Neoadjuvant Hormonal Deprivation in Patients with Locally Advanced Prostate Cancer

1993 • 90 citations

The role of neoadjuvant hormonal manipulation in localized prostatic cancer

1993 • 88 citations

Histologic changes in prostate carcinomas treated with leuprolide (luteinizing hormone–-releasing hormone effect). Distinction from poor tumor differentiation

1994 • 85 citations

Prostate Specific Antigen as an Outcome Variable for T1 and T2 Prostate Cancer Treated by Radiation Therapy

1994 • 78 citations

Expectant Management of Early Stage Prostatic Cancer: Swedish Experience

1994 • 77 citations

Practice Trends in the Diagnosis and Management of Prostate Cancer in the United States

1995 • 62 citations

Early Prostate Cancer: The National Results of Radiation Treatment from the Patterns of Care and Radiation Therapy Oncology Group Studies With Prospects for Improvement with Conformal Radiation and Adjuvant Androgen Deprivation

1994 • 57 citations

Nerve-Sparing Radical Retropubic Prostatectomy

1985 • 55 citations

Morphologic and lmmunohistochemical changes in prostate cancer after preoperative hormonal therapy. A comparative study of radical prostatectomies

1994 • 55 citations

Surgical Treatment of Locally Advanced (T3) Prostatic Carcinoma: Early Results

1987 • 54 citations

Neoadjuvant Hormonal Deprivation before Radical Prostatectomy

1993 • 54 citations

Prostate-Specific Antigen Testing in Untreated and Treated Prostatic Adenocarcinoma

1990 • 50 citations

Histopathological Changes in Androgen-Deprived Localized Prostatic Cancer

1993 • 50 citations

High failure rate associated with long‐term follow‐up of neoadjuvant androgen deprivation followed by radical prostatectomy for stage C prostatic cancer

1995 • 47 citations

ENDOCRINE THERAPY IN CARCINOMA OF THE PROSTATE

1947 • 47 citations

Surgical management of prostate cancer. Contemporary results with anatomic radical prostatectomy

1995 • 46 citations

Expectant Management of Clinically Localized Prostatic Cancer

1994 • 46 citations

Use of neoadjuvant androgen deprivation therapy in clinically localized prostate cancer.

1993 • 43 citations

Surgical management of prostate cancer. Contemporary results with anatomic radical prostatectomy

1995 • 42 citations

Neoadjuvant androgen blockade prior to prostatectomy: A retrospective study and critical review

1994 • 41 citations

Early stage prostate cancer: diagnosis and choice of therapy

1989 • 37 citations

Transrectal ultrasound evaluation of local prostate cancer in patients treated with LHRH agonist and in combination with flutamide

1992 • 36 citations

Androgen deprivation prior to radical prostatectomy for T2b and T3 prostate cancer

1994 • 33 citations

Complete Androgen Deprivation prior to Radical Prostatectomy in Patients with Stage T(3) Cancer of the Prostate

1991 • 33 citations

Luteinizing Hormone-Releasing Hormone Downstaging of Clinical Stage C Prostate Cancer

1992 • 32 citations

Hormone ablation therapy as neoadjuvant treatment to radical prostatectomy.

1993 • 30 citations

An Evaluation of Endocrine Therapy Plus Radical Perineal Prostatectomy in the Treatment of Advanced Carcinoma of the Prostate

1964 • 30 citations

Downstaging by combination therapy with flutamide and an LHRH agonist before radical prostatectomy.

1995 • 29 citations

New horizons in the surgical management of carcinoma of the prostate gland

1949 • 28 citations

Neoadjuvant Hormonal Deprivation before Radical Prostatectomy

1993 • 27 citations

Neoadjuvant GnRH-Agonist Treatment (Triptorelin and Cyproterone Acetate for Flare Protection) and Total Prostatectomy

1993 • 24 citations

Neoadjuvant hormonal therapy in stage C adenocarcinoma of the prostate.

1993 • 23 citations

Treatment of early stage prostate cancer: radical prostatectomy.

1994 • 21 citations

Neoadjuvant hormonal therapy and radical prostatectomy for clinical stage C carcinoma of the prostate

1994 • 21 citations

A Multicentre Trial of Combined Neoadjuvant Androgen Blockade with Zoladex and Flutamide prior to Radical Prostatectomy in Prostate Cancer

1994 • 20 citations

Combination of screening and preoperative endocrine therapy: the potential for an important decrease in prostate cancer mortality.

1995 • 20 citations

Hormone control therapy as a preparation for radical perineal prostatectomy in advanced carcinoma of the prostate.

1949 • 19 citations

The Effects of Treatment on the Local Lesion of Carcinoma of the Prostate

1973 • 19 citations

ENDOCRINE THERAPY IN CARCINOMA OF THE PROSTATE

1955 • 18 citations

THE ROLE OF ENDOCRINE THERAPY IN THE MANAGEMENT OF LOCAL AND DISTANT RECURRENCE OF PROSTATE CANCER FOLLOWING RADICAL PROSTATECTOMY OR RADIATION THERAPY

1994 • 18 citations

Hormonal pretreatment does not affect the final pathologic stage in locally advanced prostate cancer

1994 • 18 citations

Significance of androgen deprivation prior to radical prostatectomy, with special reference to prostate-specific antigen

1993 • 15 citations

Downstaging of Stage C Prostatic Carcinoma by Inductive Chemo-Hormonal Therapy?

1993 • 14 citations

Non-Resectable Carcinoma of the Prostate Rendered Resectable by Endocrine Therapy

1966 • 14 citations

Combination of screening and preoperative endocrine therapy: the potential for an important decrease in prostate cancer mortality

1995 • 13 citations

Prostatic Carcinoma Cured with Hormonal Treatment

1981 • 12 citations

The role of transrectal ultrasound-guided staging biopsy and androgen ablation therapy prior to radical prostatectomy.

1993 • 11 citations

Is Combined Modality Therapy Appropriate for Apparently Localized Carcinoma of the Prostate?

1991 • 11 citations

Effects of 3 Months' Neoadjuvant Hormonal Treatment with a GnRH Analogue (Triptorelin) prior to Radical Retropubic Prostatectomy on Prostate-Specific Antigen and Tumour Volume in Prostate Cancer

1994 • 10 citations

Endocrine Treatment prior to Radical Retropubic Prostatectomy in Patients with T<sub>3</sub> Prostate Cancer: A Retrospective Study of 22 Patients

1992 • 10 citations

Computer Modeling of Prostate Cancer Treatment

1995 • 10 citations

Neoadjuvant hormonal manipulation: A strategy for chemoprevention trials

1992 • 8 citations

Role of induction androgen deprivation before radical prostatectomy.

1995 • 6 citations

Treatment of early stage prostate cancer: conservative management--delayed therapy.

1994 • 2 citations

Workshop Summary: Hormonal Suppression in Neoadjuvant Setting and Advanced Disease

1993 • 2 citations