Management of fever in neutropenic patients

Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute Leukemia

1966 • 2,470 citations

2002 Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer

2002 • 1,970 citations

Liposomal Amphotericin B for Empirical Therapy in Patients with Persistent Fever and Neutropenia

1999 • 1,184 citations

The Multinational Association for Supportive Care in Cancer Risk Index: A Multinational Scoring System for Identifying Low-Risk Febrile Neutropenic Cancer Patients

2000 • 1,111 citations

2000 Update of Recommendations for the Use of Hematopoietic Colony-Stimulating Factors: Evidence-Based, Clinical Practice Guidelines

2000 • 1,061 citations

Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia

1982 • 875 citations

Empiric Therapy with Carbenicillin and Gentamicin for Febrile Patients with Cancer and Granulocytopenia

1971 • 682 citations

1997 Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Unexplained Fever

1997 • 671 citations

A Randomized Trial Comparing Ceftazidime Alone with Combination Antibiotic Therapy in Cancer Patients with Fever and Neutropenia

1986 • 601 citations

Risk assessment in cancer patients with fever and neutropenia: a prospective, two-center validation of a prediction rule.

1992 • 558 citations

American Society of Clinical Oncology. Recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines.

1994 • 438 citations

A Double-Blind Comparison of Empirical Oral and Intravenous Antibiotic Therapy for Low-Risk Febrile Patients with Neutropenia during Cancer Chemotherapy

1999 • 410 citations

Hepatic Candidiasis in Cancer Patients: The Evolving Picture of the Syndrome

1988 • 390 citations

Outcomes of Bacteremia in Patients with Cancer and Neutropenia: Observations from Two Decades of Epidemiological and Clinical Trials

1997 • 389 citations

Septicemia and Shock Syndrome Due to Viridans Streptococci: A Case-Control Study of Predisposing Factors

1992 • 386 citations

Oral versus Intravenous Empirical Antimicrobial Therapy for Fever in Patients with Granulocytopenia Who Are Receiving Cancer Chemotherapy

1999 • 378 citations

Clinical Presentation of Infection in Granulocytopenic Patients

1975 • 370 citations

Pseudomonas bacteremia. Retrospective analysis of 410 episodes

1985 • 368 citations

Empiric antifungal therapy in febrile granulocytopenic patients

1989 • 360 citations

-Lactam Resistance in Gram-Negative Bacteria: Global Trends and Clinical Impact

1992 • 340 citations

Outbreak of vancomycin-, ampicillin-, and aminoglycoside-resistant Enterococcus faecium bacteremia in an adult oncology unit

1994 • 332 citations

Infections in Patients with Chronic Lymphocytic Leukemia Treated with Fludarabine

1998 • 304 citations

Pneumonia in Febrile Neutropenic Patients and in Bone Marrow and Blood Stem-Cell Transplant Recipients: Use of High-Resolution Computed Tomography

1999 • 301 citations

Bacteremia due to viridans streptococci in neutropenic patients: A review

1994 • 301 citations

Outpatient treatment of febrile episodes in low-risk neutropenic patients with cancer

1993 • 289 citations

Gram-Positive Infections and the Use of Vancomycin in 550 Episodes of Fever and Neutropenia

1988 • 285 citations

Monotherapy with meropenem versus combination therapy with ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer. The International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer and the Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto Infection Program

1996 • 275 citations

Empirical antifungal therapy in febrile granulocytopenic patients

1989 • 272 citations

Efficacy and Toxicity of Single Daily Doses of Amikacin and Ceftriaxone versus Multiple Daily Doses of Amikacin and Ceftazidime for Infection in Patients with Cancer and Granulocytopenia

1993 • 251 citations

Pseudomonas Bacteremia

1985 • 245 citations

Recent Experience With Pseudomonas aeruginosa Bacteremia in Patients With Cancer

2000 • 239 citations

Feasibility of outpatient management of fever in cancer patients with low-risk neutropenia: Results of a prospective randomized trial

1995 • 228 citations

Vancomycin Added to Empirical Combination Antibiotic Therapy for Fever in Granulocytopenic Cancer Patients

1991 • 226 citations

A Comparison of Imipenem to Ceftazidime With or Without Amikacin as Empiric Therapy in Febrile Neutropenic Patients

1992 • 219 citations

A randomized study of carbenicillin plus cefamandole or tobramycin in the treatment of febrile episodes in cancer patients

1979 • 210 citations

Monotherapy with Meropenem versus Combination Therapy with Ceftazidime plus Amikacin as Empiric Therapy for Fever in Granulocytopenic Patients with Cancer

1997 • 196 citations

Enterococcus faecium and Enterococcus faecalis Bacteremia: Acquisition and Outcome

1995 • 195 citations

A multicenter, randomized trial of fluconazole versus amphotericin B for empiric antifungal therapy of febrile neutropenic patients with cancer∗∗Access the “Journal Club” discussion of this paper at http://www.elsevier.com/locate/ajmselect/

2000 • 192 citations

Prospective randomized comparison of three antibiotic regimens for empirical therapy of suspected bacteremic infection in febrile granulocytopenic patients

1986 • 188 citations

Beta-Lactam Antibiotic Therapy in Febrile Granulocytopenic Patients

1991 • 165 citations

Infections in cancer patients.Results with gentamicin sulfate therapy

1972 • 151 citations

Outpatient treatment of fever and neutropenia for low risk pediatric cancer patients

1999 • 150 citations

Necrotizing colitis in patients with cancer

1979 • 144 citations

Respiratory Syncytial Virus Pneumonia in Hospitalized Adult Patients with Leukemia

1995 • 140 citations

A Randomized Comparative Trial of Three Aminoglycosides—Comparison of Continuous Infusions of Gentamicin, Aaikacin and Sisomicin Combined with Carbenicillin in the Treatment of Infections in Neutropenic Patients with Malignancies

1979 • 129 citations

Liposome-Encapsulated Amphotericin B for Treatment of Disseminated Candidiasis in Neutropenic Mice

1984 • 126 citations

Fluconazole versus amphotericin B as empirical antifungal therapy of unexplained fever in granulocytopenic cancer patients: a pragmatic, multicentre, prospective and randomised clinical trial

1996 • 124 citations

New Trends in Patient Management: Risk-Based Therapy for Febrile Patients with Neutropenia

1999 • 121 citations

GRAM-NEGATIVE BACILLARY PNEUMONIA IN THE COMPROMISED HOST

1977 • 119 citations

A randomized study of ceftazidime compared to ceftazidime and tobramycin for the treatment of infections in cancer patients

1983 • 114 citations

Single-drug versus combination empirical therapy for gram-negative bacillary infections in febrile cancer patients with and without granulocytopenia

1984 • 101 citations

The Changing Epidemiology of Infections at Cancer Hospitals

1993 • 96 citations

Aztreonam therapy in neutropenic patients with cancer

1986 • 87 citations

Home treatment of febrile neutropenia: An empirical oral antibiotic regimen

1991 • 86 citations

Antibiotics in patients with neutropenia.

1984 • 83 citations

Antibiotic combinations for infections in neutropenic patients. Evaluation of carbenicillin plus either cephalothin or kanamycin

1972 • 81 citations

Can antibacterial therapy be discontinued in persistently febrile granulocytopenic cancer patients?

1984 • 76 citations

Therapeutic trials with tobramycin

1974 • 75 citations

Fungal blood cultures

1989 • 60 citations

Moxalactam Plus Ticarcillin or Tobramycin for Treatment of Febrile Episodes in Neutropenic Cancer Patients

1984 • 59 citations

A Randomized Study of Tobramycin Plus Ticarcillin, Tobramycin Plus Cephalothin and Ticarcillin, or Tobramycin Plus Mezlocillin in the Treatment of Infection in Neutropenic Patients with Malignancies

1984 • 57 citations

Cytomegalovirus Pneumonia in Adult Nontransplantation Patients with Cancer: Review of 20 Cases Occurring from 1964 Through 1990

1996 • 57 citations

Viral pneumonia in the immunocompromised adult with neoplastic disease: the role of common community respiratory viruses.

1992 • 55 citations

A double beta-lactam combination versus an aminoglycoside-containing regimen as empiric antibiotic therapy for febrile granulocytopenic cancer patients.

1986 • 54 citations

Ceftazidime Plus Amikacin Versus Ceftazidime Plus Vancomycin as Empiric Therapy in Febrile Neutropenic Children with Cancer

1991 • 54 citations

Antibiotics in Patients With Neutropenia

1984 • 52 citations

Imipenem and cephem resistant Pseudomonas aeruginosa carrying plasmids coding for class B β-lactamase

1996 • 48 citations

Imipenem or cefoperazone-sulbactam combined with vancomycin for therapy of presumed or proven infection in neutropenic cancer patients

1996 • 40 citations

Clinical perspectives of granulocyte transfusions: Efficacy to date

1995 • 37 citations

Chemotherapy-induced neutropenia and fever in patients with metastatic breast carcinoma receiving salvage chemotherapy

1997 • 36 citations

Complications of Bacteremia Due to Stomatococcus mucilaginosus in Neutropenic Children

1993 • 36 citations

Use of Gamma Globulin in Infection in Acute-Leukemia Patients

1964 • 32 citations

Intravenous ciprofloxacin for infections in cancer patients

1989 • 26 citations

Clinical Applications of Cytokines and Growth Factors

1999 • 21 citations

Post-sepsis prophylaxis in cancer patients

1984 • 20 citations

The Changing Spectrum of Bacterial Infections in Febrile Neutropenic Patients

1997 • 19 citations

Randomized multicentre study of ciprofloxacin and azlocillin versus gentamicin and azlocillin in the treatment of febrile neutropenic patients

1990 • 19 citations

Cefoperazone plus mezlocillin for empiric therapy of febrile cancer patients

1988 • 16 citations

Ceftazidime with or without amikacin for the empiric treatment of localized infections in febrile, granulocytopenic patients

1991 • 14 citations

The Use of Hematopoietic Growth Factors for Recruitment of Leukocytes for Transfusion

1999 • 4 citations