Let's get specific: the relationship between specificity and affinity

The RNA world

1986 • 1,961 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

High-Resolution Molecular Discrimination by RNA

1994 • 1,126 citations

Three-dimensional structure of a hammerhead ribozyme

1994 • 944 citations

DIVERSITY OF OLIGONUCLEOTIDE FUNCTIONS

1995 • 794 citations

[15] Libraries of peptides and proteins displayed on filamentous phage

1993 • 770 citations

The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage

1995 • 675 citations

An RNA motif that binds ATP

1993 • 577 citations

The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.

1993 • 449 citations

The Shape of Things to Come

1933 • 436 citations

The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.

1993 • 420 citations

Three-Dimensional Structure of Yeast Phenylalanine Transfer RNA: Folding of the Polynucleotide Chain

1973 • 405 citations

Three-dimensional Solution Structure of the Thrombin-binding DNA Aptamer d(GGTTGGTGTGGTTGG)

1994 • 379 citations

On the specificity of DNA-protein interactions.

1986 • 308 citations

Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor

1995 • 276 citations

Oligonucleotides as Research, Diagnostic, and Therapeutic Agents

1995 • 262 citations

RNA aptamers that bind flavin and nicotinamide redox cofactors

1995 • 193 citations

Three small ribooligonucleotides with specific arginine sites

1993 • 183 citations

Inhibition of receptor binding by high-affinity RNA ligands to vascular endothelial growth factor

1994 • 179 citations

High-affinity ssDNA inhibitors of the reverse transcriptase of type 1 human immunodeficiency virus

1995 • 165 citations

Stereospecific recognition of tryptophan agarose by in vitro selected RNA

1992 • 149 citations

High-affinity RNA ligands to basic fibroblast growth factor inhibit receptor binding.

1993 • 145 citations

In Vitro Selection of RNA Ligands to Substance P

1995 • 117 citations

An RNA pocket for an aliphatic hydrophobe

1994 • 117 citations

In vitro selection of RNA-based irreversible inhibitors of human neutrophil elastase

1995 • 71 citations

[26] Novel methods of generating specific oligonucleotide inhibitors of viral polymerases

1996 • 4 citations