Aripiprazole (OPC-14597) fully substitutes for the 5-HT 1A receptor agonist LY293284 in the drug discrimination assay in rats
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References (60)
A simplified method of evaluating dose-effect experiments.
1948 • 7,047 citations
Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology
2003 • 918 citations
Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors
2002 • 896 citations
The Role of Serotonin in Antipsychotic Drug Action
1999 • 672 citations
A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635
1995 • 610 citations
Binding of antipsychotic drugs to human brain receptors
2000 • 594 citations
The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor
2002 • 506 citations
5-HT1A receptor agonists: recent developments and controversial issues
1995 • 463 citations
Interactions of the Novel Antipsychotic Aripiprazole (OPC-14597) with Dopamine and Serotonin Receptor Subtypes
1999 • 407 citations
Serotonin Uptake Sites and Serotonin Receptors Are Altered in the Limbic System of Schizophrenics
1993 • 350 citations
Improving the treatment of schizophrenia: focus on serotonin (5-HT)(1A) receptors.
2000 • 290 citations
7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity.
1995 • 268 citations
The 5-HT1A receptor in schizophrenia: a promising target for novel atypical neuroleptics?
2001 • 214 citations
Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia
1991 • 169 citations
Inhibition of dopamine neuron firing by pramipexole, a dopamine D3 receptor-preferring agonist: comparison to other dopamine receptor agonists
1996 • 160 citations
Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia
1996 • 153 citations
Serotonergic involvement in haloperidol-induced catalepsy.
1993 • 144 citations
Serotonergic mechanisms in neuroleptic-induced catalepsy in the rat
1996 • 140 citations
8-hydroxy-2-(di-N-propylamino) tetralin, a selective serotonin1A receptor agonist, blocks haloperidol-induced catalepsy by an action on raphe nuclei medianus and dorsalis
1988 • 126 citations
Aripiprazole: profile on efficacy and safety
2002 • 126 citations
Agonist activity of LSD and lisuride at cloned 5HT 2A and 5HT 2C receptors
1998 • 121 citations
The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development
2002 • 117 citations
Antipsychotic-like profile of combined treatment with raclopride and 8-OH-DPAT in the rat: enhancement of antipsychotic-like effects without catalepsy
1991 • 106 citations
Behavioural and neurochemical effects of OPC-14597, a novel antipsychotic drug, on dopaminergic mechanisms in rat brain
1995 • 91 citations
Effects of the novel antipsychotic agent 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro -2(1H)-quinolinone (OPC-14597) on prolactin release from the rat anterior pituitary gland.
1996 • 90 citations
α2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs
2003 • 86 citations
5-HT1A receptor activation and anti-cataleptic effects: high-efficacy agonists maximally inhibit haloperidol-induced catalepsy
2002 • 86 citations
Do autoreceptors mediate dopamine agonist — induced yawning and suppression of exploration? A critical review
1992 • 86 citations
Agonist high and low affinity state ratios predict drug intrinsic activity and a revised Ternary complex mechanism at serotonin 5-HT2A and 5-HT2C receptors
2000 • 75 citations
Clozapine has sub-micromolar affinity for 5-HT1A receptors in human brain tissue
1992 • 64 citations
Effect of metergoline, fenfluramine, and 8-OHDPAT on catalepsy induced by haloperidol or morphine
1988 • 63 citations
Interactions between neuroleptics and 5-HT 1A ligands in preclinical behavioral models for antipsychotic and extrapyramidal effects
1999 • 63 citations
Reversal of neuroleptic-induced catalepsy by novel aryl-piperazine anxiolytic drugs
1988 • 62 citations
Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine 1A receptor-mediated behavioral effects overlap its other properties in rats
2002 • 56 citations
5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine
1997 • 53 citations
Reversal of Haloperidol-Induced Extrapyramidal Side Effects in Cebus Monkeys by 8-Hydroxy-2-(di-n-propylamino)tetralin and Its Enantiomers
1998 • 39 citations
Clozapine decreases serotonin extracellular levels in the nucleus accumbens by a dopamine receptor-independent mechanism
1995 • 37 citations
Inhibition by a putative antipsychotic quinolinone derivative (OPC-14597) of dopaminergic neurons in the ventral tegmental area
1996 • 34 citations
Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity.
1994 • 33 citations
Prevention by (±)‐8‐hydroxy‐2‐(di‐npropylamino)tetralin of both catalepsy and the rises in rat striatal dopamine metabolism caused by haloperidol
1996 • 33 citations
Partial agonistic effects of OPC-14597, a potential antipsychotic agent, on yawning behavior in rats
1996 • 32 citations
Behavioral effects of the highly selective serotonin releasing agent 5-methoxy-6-methyl-2-aminoindan
1994 • 32 citations
Antipsychotic‐like Properties of the 5‐HT1A Agonist 8‐OH–DPAT in the Rat
1989 • 32 citations
Limbic circuits and monoamine receptors: Dissecting the effects of antipsy chotics from disease processes
1997 • 31 citations
Neurochemical and behavioural evidence for an agonist action of 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (LY 165163) at central 5-HT receptors
1987 • 30 citations
Characterisation of Recombinant Serotonin 5‐HT1A Receptors Expressed in Chinese Hamster Ovary Cells: The Agonist [3H]Lisuride Labels Free Receptor and Receptor Coupled to G Protein
1995 • 29 citations
Yawning and suppression of exploration induced by dopamine agonists: No relation to extracellular striatal levels of dopamine
1990 • 27 citations
Effect of tandospirone on tardive dyskinesia and parkinsonian symptoms
1998 • 25 citations
Agonist-stimulated GTPγ[35S] binding to 5-HT1A receptors in human post-mortem brain
1999 • 24 citations
Repeated treatment with 8-OH-DPAT induces tolerance to its ability to produce the 5-HT1A behavioural syndrome, but not to its ability to attenuate haloperidol-induced catalepsy
2000 • 21 citations
5-HT1A receptors and the tail-flick response. VI. Intrinsic alpha 1A-adrenoceptor antagonist properties can mask the actions of 5-HT1A receptor agonists in the spontaneous tail-flick paradigm.
1994 • 20 citations
5-HT1A receptors and the tail-flick response. V. Opposite modulation of 5-HT1A receptor-induced spontaneous tail-flicks by alpha 1A- as compared with alpha 2D-adrenoceptors in rat lumbar spinal cord.
1994 • 17 citations
Blockade of dopamine receptors explains the lack of 5-HT stereotypy on treatment with the putative 5-HT1A agonist LY165163
1987 • 15 citations
In vitro selectivity of lisuride and other ergot derivatives for α1- and α2-adrenoceptors
1984 • 14 citations
Effects of WAY 100635 on antipsychotic-induced catalepsy in 5-HT depleted animals: a role for tonic activation of 5-HT1A receptors
2000 • 14 citations
A9 and A10 dopamine nuclei as a site of action for effects of 8-OH-DPAT on locomotion in the rat
2000 • 9 citations
Antagonist properties of LY 165,163 at pre- and postsynaptic dopamine D2, D3 and D1 receptors: modulation of agonist actions at 5-HT1A receptors in vivo.
1995 • 9 citations
Pharmacology of a mixed 5-hydroxytryptamine1A/dopamine agonist.
1994 • 8 citations
Neurochemical Modulation of the Hippocampus in Learning, Remembering and Forgetting in Primates
1996 • 7 citations
An in vivo assessment of aripiprazole, ziprasidone, risperidone and olanzapine in rat assays indicative of 5-HT1A and D2 receptor activity
2003 • 4 citations