Fibrinolytic mechanisms and the development of thrombolytic therapy

THE MECHANISM OF CLOT DISSOLUTION BY PLASMIN*

1959 • 581 citations

ε-Aminocaproic Acid: an Inhibitor of Plasminogen Activation

1959 • 459 citations

Fibrinolysis and Fibrinolytic Activity in Man

1959 • 350 citations

Analytical Review: Fibrinolysis in the Organism

1956 • 305 citations

PARTIAL PURIFICATION AND PROPERTIES OF A PROTEOLYTIC ENZYME OF HUMAN SERUM

1949 • 299 citations

Circulating anticoagulants: a study of 40 cases and a review of the literature.

1961 • 285 citations

STUDIES ON ENHANCED FIBRINOLYTIC ACTIVITY IN MAN*

1959 • 285 citations

THE MAINTENANCE OF A SUSTAINED THROMBOLYTIC STATE IN MAN. I. INDUCTION AND EFFECTS*

1959 • 243 citations

CIRCULATING ANTICOAGULANTS

1961 • 223 citations

EFFECT OF CHOLESTEROL, CHOLESTEROL ESTERS, AND NEUTRAL FATS ON FIBRINOLYSIS

1959 • 219 citations

THE MAINTENANCE OF A SUSTAINED THROMBOLYTIC STATE IN MAN. II. CLINICAL OBSERVATIONS ON PATIENTS WITH MYOCARDIAL INFARCTION AND OTHER THROMBOEMBOLIC DISORDERS*†

1959 • 208 citations

METHODS FOR MEASURING THE ACTIVITY OF COMPONENTS OF THE STREPTOCOCCAL FIBRINOLYTIC SYSTEM, AND STREPTOCOCCAL DESOXYRIBONUCLEASE 1

1949 • 197 citations

THE PURIFICATION AND CRYSTALLIZATION OF PLASMINOGEN (PROFIBRINOLYSIN)

1953 • 196 citations

The lysis of artificially induced intravascular clots in man by intravenous infusions of purified streptokinase.

1958 • 186 citations

The Fibrinolytic Activity of Human Tissues

1957 • 173 citations

PATHOGENESIS OF THE COAGULATION DEFECT DEVELOPING DURING PATHOLOGICAL PLASMA PROTEOLYTIC (“FIBRINOLYTIC”) STATES. II. THE SIGNIFICANCE, MECHANISM AND CONSEQUENCES OF DEFECTIVE FIBRIN POLYMERIZATION*

1962 • 172 citations

FIBRINOLYSIS. ITS MECHANISM AND SIGNIFICANCE

1948 • 168 citations

PATHOGENESIS OF THE COAGULATION DEFECT DEVELOPING DURING PATHOLOGICAL PLASMA PROTEOLYTIC (“FIBRINOLYTIC”) STATES. I. THE SIGNIFICANCE OF FIBRINOGEN PROTEOLYSIS AND CIRCULATING FIBRINOGEN BREAKDOWN PRODUCTS*

1962 • 164 citations

THE LYSIS OF ARTIFICIALLY INDUCED INTRAVASCULAR CLOTS IN MAN BY INTRAVENOUS INFUSIONS OF STREPTOKINASE*†

1959 • 159 citations

Inhibition of plasmin, trypsin and the streptokinase-activated fibrinolytic system by ϵ-aminocaproic acid

1959 • 158 citations

Severe Thrombotic Disease in a Young Man with Bone Marrow and Skeletal Changes and with a High Content of an Inhibitor in the Fibrinolytic System

1961 • 155 citations

The treatment of patients suffering from early myocardial infarction with massive and prolonged streptokinase therapy.

1958 • 152 citations

The preparation of human fibrinogen free of plasminogen

1962 • 149 citations

Thrombotic state after a hemorrhagic diathesis, a possible complication of therapy with epsilon-aminocapproic acid.

1962 • 136 citations

ANTIFIBRINOLYTIC ACTIVITY AND METABOLISM OF Σ-AMINOCAPROIC ACID IN MAN

1960 • 129 citations

Experimental pulmonary arteriosclerosis

1948 • 127 citations

Thrombotic State after a Hemorrhagic Diathesis, a Possible Complication of Therapy with Epsilon-Aminocaproic Acid

1962 • 125 citations

STUDIES OF THE PLASMIN SYSTEM

1958 • 120 citations

The Existence of Antifibrinolysin Activity in Platelets

1953 • 116 citations

THE INTRAVENOUS INFUSION OF THE STREPTOCOCCAL FIBRINOLYTIC PRINCIPLE (STREPTOKINASE) INTO PATIENTS 1

1955 • 114 citations

Blood Coagulation and Fibrinolysis in Relation to Coronary Heart Disease

1960 • 112 citations

Plasmin-antiplasmin complex as a reservoir of fibrinolytic enzyme

1960 • 107 citations

STUDIES OF THE PLASMIN SYSTEM

1958 • 107 citations

STUDIES OF THE PLASMIN SYSTEM

1957 • 106 citations

STUDIES ON THE THROMBOLYTIC ACTIVITY OF HUMAN PLASMA *

1960 • 102 citations

ACTIVE HAGEMAN FACTOR: A PLASMA LYSOKINASE OF THE HUMAN FIBRINOLYTIC SYSTEM*

1962 • 101 citations

The Activation of Human Plasminogen

1958 • 100 citations

PATHOGENESIS OF THE COAGULATION DEFECT DEVELOPING DURING PATHOLOGICAL PLASMA PROTEOLYTIC (“FIBRINOLYTIC”) STATES. III. DEMONSTRATION OF ABNORMAL CLOT STRUCTURE BY ELECTRON MICROSCOPY*

1962 • 98 citations

The Use of Epsilon Aminocaproic Acid, a Potent Inhibitor of Fibrinolytic Activity, in the Management of Postoperative Hematuria

1961 • 97 citations

PLASMA FIBRINOLYTIC ACTIVITY IN CIRRHOSIS OF THE LIVER

1956 • 96 citations

The Activation of Human Plasminogen

1958 • 96 citations

The Enzymatic Dissolution Of Experimental Arterial Thrombi in the Dog by Trypsin, Chymotrypsin and Plasminogen Activators12

1954 • 87 citations

STUDIES ON THE INHIBITION OF FIBRINOLYSIS BY LIPIDS

1957 • 85 citations

Rôle du Facteur Contact (Facteur Hageman) dans la Fibrinolyse

1959 • 84 citations

Inhibition of fibrin polymerization by fibrinogen proteolysis products

1962 • 81 citations

Thromboplastic and Fibrinolytic Activity of the Human Aorta

1959 • 80 citations

Clinical Experiences with ε‐Aminocaproic Acid (ε‐ACA) as an Antifibrinolytic Agent

1961 • 79 citations

The Clearance of Heterologous Protein from the Circulation of Normal and Immunized Man12

1958 • 74 citations

ETIOLOGY OF FIBRINOPENIA: FIBRINATION DEFIBRINATION*

1959 • 73 citations

On the production of plasma fibrinolytic activity within veins.

1957 • 71 citations

Physicochemical Studies on Human Plasminogen (Profibrinolysin) and Plasmin (Fibrinolysin)

1958 • 71 citations

Influence of pH, ionic strength, neutral ions, and thrombin on fibrin polymerization

1962 • 70 citations

Proteolytic enzymes: a therapeutic evaluation

1960 • 69 citations

Fibrinolytic (Plasmin) Therapy of Experimental Coronary Thrombi with Alteration of the Evolution of Myocardial Infarction

1959 • 67 citations

Enzymes in Health and Disease

1961 • 65 citations

THE ACTIVATION OF PLASMINOGEN BY CHLOROFORM

1946 • 64 citations

FIBRINOLYTIC ACTIVITY OF THE BLOOD IN INTERMITTENT CLAUDICATION

1959 • 63 citations

STUDIES ON THE INHIBITION OF PROTEOLYTIC ENZYMES BY SERUM

1952 • 62 citations

An experimental study of thickening of the pulmonary arteries of rabbits produced by the organisation of fibrin

1952 • 62 citations

FIBRINOLYSIS IN MYOCARDIAL INFARCTION

1958 • 61 citations

Occurrence of Fibrinolytic Activity Following Administration of Nicotinic Acid

1958 • 59 citations

The biochemistry and physiology of urokinase

1960 • 58 citations

Reduction of Postprostatectomy Bleeding by Epsilon-Aminocaproic Acid

1962 • 56 citations

Hemorrhagic States during Pregnancy

1955 • 54 citations

Study on the Effect of Streptokinase-Activated Plasmin (Fibrinolysin) on Clots in Various Stages of Organization12

1958 • 52 citations

The Fibrinolytic Activity of Animal Tissues

1957 • 51 citations

Hemorrhagic States during Pregnancy

1955 • 50 citations

Variation in Fibrinolytic Activity After Acute Myocardial Infarction and After the Administration of Oral Anticoagulant Drugs and Intravenous Heparin

1960 • 46 citations

Impairment of hemostasis in the urinary tract: the role of urokinase.

1961 • 43 citations

Studies on a proteolytic enzyme in human plasma; the rate of lysis of plasma clots in normal and diseased individuals, with particular reference to hepatic diseases.

1949 • 42 citations

Improved Procedure for the Isolation of Human Plasminogen

1961 • 42 citations

STUDIES ON A PROTEOLYTIC ENZYME IN HUMAN PLASMA

1952 • 42 citations

Studies concerning the turnover of fibrinogen I-131 in the dog.

1961 • 41 citations

Salvage of heart muscle by fibrinolytic therapy after experimental coronary occlusion

1961 • 41 citations

Die Wirkung intravenös applizierter Streptokinase auf Fibrinolyse und Blutgerinnung

1960 • 39 citations

On the Lysis of Thrombi Experimentally Produced within Veins

1958 • 39 citations

DEVELOPMENTS IN FIBRINOLYTIC THERAPY FOR THROMBO-EMBOLIC DISEASE

1959 • 37 citations

Physical Properties of Highly Purified Human Plasminogen

1960 • 37 citations

Thrombin-E as a Fibrinolytic Enzyme

1960 • 35 citations

The production of plasma fibrinolytic activity in vivo by serotonin (5-hydroxytryptamine) creatinine sulphate.

1957 • 35 citations

Inhibition of Fibrinolysis in vivo by feeding Cholesterol

1957 • 34 citations

Thrombolytic Therapy

1961 • 32 citations

A Comparison of the Fibrinolytic and Fibrinogenolytic Effects of Plasminogen Activators and Proteolytic Enzymes in Plasma

1961 • 31 citations

Nature of the thrombin-inhibiting effect of incubated fibrinogen

1959 • 31 citations

THE INTRAVASCULAR USE OF STREPTOKINASE

1957 • 31 citations

LIPÆMIA AND BLOOD-COAGULATION DEFECTS IN RELATION TO ISCHÆMIC HEART-DISEASE

1961 • 30 citations

On Plasma Fibrinolytic Activity in Cryptogenetic Splenomegaly

1957 • 29 citations

Urokinase Excretion in Health and its Alteration in Certain Disease States

1959 • 28 citations

On the Mechanism of Thrombolysis by Plasmin

1962 • 28 citations

Fibrinolysokinase Activity in Animal and Human Tissue¹

1956 • 25 citations

EVALUATION OF HUMAN FIBRINOLYSIN (ACTASE)

1960 • 23 citations

Postoperative Hypofibrinogenemia

1957 • 22 citations

Effect of Anticoagulants on Experimental Cerebral Infarction

1959 • 21 citations

Methods Employed for Purification of Streptokinase.

1957 • 19 citations

Intravenous Trypsin in Experimental Myocardial Infarction

1954 • 19 citations

Effect of Chylomicrons on the Fibrinolytic Activity of Normal Human Plasma in Vitro

1959 • 19 citations

Effects in Patients of Intravenous Infusions of Purified Streptokinase Preparations.

1957 • 17 citations

Enzymes in health and disease

1960 • 16 citations

Assay of thrombolytic ('fibrinolytic') mixtures intended for therapeutic use.

1961 • 15 citations

Disappearance of clot-emboli in rabbits.

1962 • 13 citations

The Effect of Alimentary Hyperlipemia on Thrombolysis in vivo

1960 • 13 citations

Thrombolytic (Fibrinolytic) Therapy for Coronary Heart Disease

1960 • 12 citations

On the inhibition of plasma fibrinolytic activity by exercised ischaemic muscles.

1958 • 12 citations

EFFECT OF CHOLESTEROL, CHOLESTEROL ESTERS, AND NEUTRAL FATS ON FIBRINOLYSIS

1959 • 11 citations

Urokinase excretion in patients with carcinoma

1961 • 9 citations

Evaluation of Human Fibrinolysin (Actase)

1960 • 9 citations

Symposium on Fibrinolysis

1963 • 8 citations

Fibrinolysis. V. The thrombolytic and anticoagulant activity of mold fibrinolysin (Aspergillin O) in vivo.

1961 • 7 citations

Some Aspects of the Mechanism of Thrombolysis

1961 • 5 citations

The fibrinolytic system: a review of its therapeutic significance and control, with particular emphasis on its inhibition by e-aminocaproic acid.

1961 • 5 citations

Thrombolytic therapy

1961 • 4 citations

Chemistry of fibrinolysis.

1961 • 1 citations