Theoretical drug design: 6‐Azauridine‐5′‐phosphate—its X‐ray crystal structure, potential energy maps, and mechanism of inhibition of orotidine‐5′‐phosphate decarboxylase

A Simplex Method for Function Minimization

1965 • 27,535 citations

Conformation of Polypeptides and Proteins

1968 • 2,929 citations

The geometry of nucleic acids

1970 • 325 citations

Stereochemistry of Reaction Paths as Determined from Crystal Structure Data—A Relationship between Structure and Energy

1975 • 229 citations

Orotidylic Acid Decarboxylase: Inhibition Studies with Azauridine 5′-Phosphate

1960 • 186 citations

Van Der Waals Interaction and the Stability of Helical Polypeptide Chains

1965 • 182 citations

An obligatory α‐helical amino acid residue

1973 • 169 citations

The crystal and molecular structure of<scp>D</scp>(+)-barium uridine-5'-phosphate

1965 • 148 citations

Structure and Function of Nucleosides and Nucleotides

1973 • 135 citations

Uridine Kinase from Ehrlich Ascites Tumor: Purification and Properties

1960 • 129 citations

Stereochemistry of nucleic acids and polynucleotides. IV. Conformational energy of base-sugar units

1969 • 119 citations

A refinement of the crystal structure of cytidine

1965 • 118 citations

Crystal structure and molecular conformation of formycin monohydrates. Possible origin of the anomalous circular dichroic spectra in formycin mono- and polynucleotides

1973 • 100 citations

Stereochemistry of a substrate for pancreatic ribonuclease. Crystal and molecular structure of the triethylammonium salt of uridine 2', 3'-0,0-cyclophosphorothioate

1970 • 100 citations

The stereochemical code and the logic of a protein molecule

1969 • 99 citations

Calculation of Van der Waals Interactions and Hydrogen Bonding in Crystals

1969 • 99 citations

Stereochemistry of nucleic acids and polynucleotides. II. Allowed conformations of the monomer unit for different ribose puckerings

1970 • 94 citations

Uridine and deoxyuridine phosphorylases from Ehrlich ascites tumor

1961 • 94 citations

Kinetic Properties and Inhibition of Orotidine 5′-Phosphate Decarboxylase

1973 • 83 citations

Nucleic Acid Conformation: Crystal Structure of a Naturally Occurring Dinucleoside Phosphate (UpA)

1971 • 68 citations

Mechanism of Action and Application of Azapyrimidines

1963 • 65 citations

Stereochemistry of nucleic acids and polynucleotides. V. Conformational energy of a ribose‐phosphale unit

1969 • 63 citations

Molecular and crystal structure of 6-methyluridine, a pyrimidine nucleoside in the syn conformation

1972 • 61 citations

Molecular orbital calculations on the conformation of nucleic acids and their constituents. IV. Conformations about the exocyclic C(4′)-C(5′) bond

1972 • 60 citations

Interconversion of different molecular weight forms of human erythrocyte orotidylate decarboxylase.

1975 • 59 citations

Stereochemistry of nucleic acids and their constituents. XXIX. Crystal and molecular structure of allopurinol, a potent inhibitor of xanthine oxidase

1972 • 51 citations

The Crystal Structure of Orotic Acid Monohydrate (Vitamin B13)

1973 • 51 citations

6-Azauridine, a nucleoside with unusual ribose conformation

1973 • 49 citations

6-Azauridine-5′-phosphoric Acid: Unusual Molecular Structure and Functional Mechanism

1973 • 40 citations

8-Azaadenosine. Crystallographic evidence for a high-anti conformation around a shortened glycosidic linkage

1974 • 40 citations

Conformational studies on pyrimidine 5′‐monophosphates and 3′,5′‐diphosphates. Effect of the phosphate groups on the backbone conformation of polynucleotides

1973 • 40 citations

Classical potential energy calculations for ApA, CpC, GpG, and UpU. The influence of the bases on RNA subunit conformations

1975 • 39 citations

Aza analogs of nucleic acid constituents. IV. The crystal and molecular structure of 6-azauracil

1974 • 31 citations

An uncommon nucleotide conformation shown by molecular structure of deoxyuridine-5′-phosphate and nucleic acid stereochemistry

1975 • 25 citations

High-anticonformation in o-azanucleosides. Crystal and molecular structure of 6-azacytidine

1974 • 22 citations

Xanthosine dihydrate

1976 • 22 citations

Conformational analysis of polynucleotide chains. Double‐stranded structures

1975 • 21 citations

Molecular and crystal structure of deoxyguanosine 5′-phosphate

1974 • 21 citations

Optical Rotatory Studies on Nucleic Acid Derivatives n–π^* Transitions and the Relation of the B_2u Cotton Effect to Conformation in Pyrimidine and Azapyrimidine Nucleosides

1971 • 20 citations

Conformation of 6-Methyluridine — a Pyrimidine Nucleoside in the syn Conformation

1972 • 19 citations

6-Azauridine: Crystal structure and conformation of the antileukemia drug

1971 • 12 citations

The sign of theB_2u cotton effect and the conformation of pyrimidine and azapyrimidine nucleosides

1972 • 10 citations

The X-ray crystal and molecular structure of the nucleoside β-uridine

1971 • 10 citations