Imipramine induced lipidosis and dexamethasone effect: morphological and biochemical study in normal and chronic GM2 gangliosidosis fibroblasts

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.

1980 • 743 citations

Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances.

1981 • 424 citations

Mechanism by which psychotropic drugs inhibit adenosine cyclic 3',5'-monophosphate phosphodiesterase of brain.

1976 • 389 citations

Amiodarone hepatotoxicity: Prevalence and clinicopathologic correlations among 104 patients

1989 • 257 citations

Regulation of endocytic pH by the Na+,K+-ATPase in living cells.

1989 • 228 citations

Gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts. Quantitative ultrastructural and biochemical study.

1979 • 141 citations

Genetic metabolic diseases : early diagnosis and prenatal analysis

1980 • 140 citations

Dexamethasone increases expression of mannose receptors and decreases extracellular lysosomal enzyme accumulation in macrophages.

1985 • 139 citations

Hexosaminidase A deficiency in adults

1986 • 115 citations

Effect of lysosomotropic amines on the secretory pathway and on the recycling of the asialoglycoprotein receptor in human hepatoma cells.

1985 • 94 citations

Studies on Drug-induced Lipidosis: III. Lipid Composition of the Liver and Some Other Tissues in Clinical Cases of “Niemann-Pick-like Syndrome” Induced by 4, 4′-Diethylaminoethoxyhexestrol

1971 • 94 citations

Abnormal cholesterol metabolism in imipramine-treated fibroblast cultures. Similarities with Niemann-Pick type C disease

1990 • 93 citations

Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines

1986 • 91 citations

Molecular studies of the induction of cellular phospholipidosis by cationic amphiphilic drugs.

1984 • 61 citations

The Clinical Aspects of Adult Hexosaminidase Deficiencies

1991 • 49 citations

Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs

1975 • 38 citations

Stimulating effects of prednisolone on acetylcholine receptor expression and myogenesis in primary culture of newborn rat muscle cells

1989 • 30 citations

Depletion of cellular β-hexosaminidase by imipramine is prevented by dexamethasone; implications for treating psychotic hexosaminidase-A deficient patients

1987 • 13 citations

Perhexiline Maleate Induced Lipidosis in Human Peripheral Nerve and Tissue Culture: Ultrastructural and Biochemical Changes

1981 • 9 citations

Effect of Tricyclic Antidepressants on Lysosomal Sphingomyelinase Activity

1988 • 2 citations