The vitamin D endocrine system: Manipulation of structure-function relationships to provide opportunities for development of new cancer chemopreventive and immunosuppressive agents

Structure-Function Relationships in the Vitamin D Endocrine System*

1995 • 1,182 citations

The Role of the Vitamin D Endocrine System in Health and Disease

1989 • 1,041 citations

1,25(OH) ₂ ‐Vitamin D ₃ receptors: gene regulation and genetic circuitry

1988 • 455 citations

Identification of a specific binding protein for 1 alpha,25-dihydroxyvitamin D3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachia.

1994 • 310 citations

Vitamin D : the calcium homeostatic steroid hormone

1979 • 268 citations

Calcium Transport in Perfused Duodena from Normal Chicks: Enhancement within Fourteen Minutes of Exposure to 1,25-Dihydroxyvitamin D₃*

1984 • 262 citations

Vitamin D3 Metabolites Modulate Dihydropyridine-sensitive Calcium Currents in Clonal Rat Osteosarcoma Cells

1989 • 241 citations

1,25(OH)2-vitamin D3, a steroid hormone that produces biologic effects via both genomic and nongenomic pathways

1992 • 222 citations

Demonstration that 1 beta,25-dihydroxyvitamin D3 is an antagonist of the nongenomic but not genomic biological responses and biological profile of the three A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D3.

1993 • 182 citations

1,25-Dihydroxy-16-ene-23-yne-vitamin D3 prolongs survival time of leukemic mice.

1990 • 167 citations

Novel vitamin D analogs that modulate leukemic cell growth and differentiation with little effect on either intestinal calcium absorption or bone mobilization

1989 • 133 citations

Antitumor effect of 22-oxa-calcitriol, a noncalcemic analogue of calcitriol, in athymic mice implanted with human breast carcinoma and its synergism with tamoxifen.

1993 • 109 citations

EB 1089, a novel vitamin D analogue, has strong antiproliferative and differentiation inducing effects on cancer cells

1993 • 106 citations

Influx of Extracellular Calcium Mediates 1,25-Dihydroxyvitamin D3-Dependent Transcaltachia (the Rapid Stimulation of Duodenal Ca2+ Transport)*

1990 • 101 citations

Calcipotriol (MC 903): Pharmacokinetics in rats and biological activities of metabolites

1991 • 99 citations

Structure-function studies on analogues of 1 alpha,25-dihydroxyvitamin D3: differential effects on leukemic cell growth, differentiation, and intestinal calcium absorption.

1990 • 99 citations

Induction of glioma cell death by 1,25 (OH)₂ vitamin D₃: Towards an endocrine therapy of brain tumors?

1994 • 92 citations

A vitamin D analogue (EB1089) inhibits parathyroid hormone-related peptide production and prevents the development of malignancy-associated hypercalcemia in vivo.

1993 • 90 citations

Structure-function studies of 1,25-dihydroxyvitamin D3 and the vitamin D endocrine system. 1,25-dihydroxy-pentadeuterio-previtamin D3 (as a 6-s-cis analog) stimulates nongenomic but not genomic biological responses

1993 • 89 citations

1,24(R)‐Dihydroxyvitamin D₃, a Novel Active Form of Vitamin D₃ with High Activity for Inducing Epidermal Differentiation but Decreased Hypercalcemic Activity

1990 • 87 citations

Inhibition of tumor cell-induced angiogenesis by retinoids, 1,25-dihydroxyvitamin D3 and their combination

1993 • 87 citations

Profile of ligand specificity of the vitamin D binding protein for 1α,25-dihydroxyvitamin d3 and its analogs

1994 • 80 citations

Vitamin D in Solution: Conformations of Vitamin D ₃ , 1α,25-Dihydroxyvitamin D ₃ , and Dihydrotachysterol ₃

1974 • 79 citations

Increased biological activity of 20-EPI-1,25-dihydroxyvitamin D3 is due to reduced catabolism and altered protein binding

1994 • 74 citations

PROLONGATION OF THE SURVIVAL OF MURINE CARDIAC ALLOGRAFTS BY THE VITAMIN D3 ANALOGUE 1,25-DIHYDROXY-Δ16-CHOLECALCIFEROL

1992 • 61 citations

Vitamin D: Structure‐function analyses and the design of analogs

1992 • 61 citations

Single and combined effects of the vitamin D analogue KH1060 and cyclosporin A on mercuric-chloride-induced autoimmune disease in the BN rat

1992 • 56 citations

Nontranscriptional effects of steroid hormones.

1993 • 55 citations

Protection from chemotherapy-induced alopecia by 1,25-dihydroxyvitamin D3.

1992 • 48 citations

Long-term treatment of chronic plaque psoriasis with calcipotriol

1993 • 42 citations

1α,24R-Dihydroxyvitamin D₃Has an Ability Comparable to That of 1α,25-Dihydroxyvitamin D₃to Induce Keratinocyte Differentiation

1990 • 37 citations

Selective biological response by target organs (intestine, kidney, and bone) to 1,25-dihydroxyvitamin D3 and two analogues.

1993 • 24 citations

Effect of 1,25(OH)2D3 and its analogues on membrane phosphoinositide turnover and [Ca2+]i in Caco-2 cells

1993 • 16 citations

Serum and Renal Histologic Changes in the Rat Following Adminstation of Toxic Amounts of 1,25-Dihydroxyvitamin D₃

1977 • 8 citations

Effect of three A-ring analogs of 1α,25-dihydroxyvitamin D3 on 25-OH-D3-1α-hydroxylase in isolated mitochondria and on 25-hydroxyvitamin D3 metabolism in cultured kidney cells

1991 • 4 citations

STRUCTURE-FUNCTION RELATIONSHIPS IN THE VITAMIN D ENDOCRINE SYSTEM FOR l,25(OH)2D3 ANALOGS

1991 • 4 citations