Different hepatocytes express the cholesterol 7α-hydroxylase gene during its circadian modulationin vivo

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Cholesterol 7α-hydroxylase

1977 • 504 citations

Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture.

1983 • 373 citations

Subdivision of hexagonal liver lobules into a structural and functional unit. Role in hepatic physiology and pathology

1954 • 371 citations

Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis.

1990 • 365 citations

Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP.

1993 • 293 citations

Biochemical site of regulation of bile acid biosynthesis in the rat

1970 • 250 citations

Feedback regulation of bile acid biosynthesis in the rat

1969 • 234 citations

Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm

1990 • 218 citations

Regulatory effects of sterols and bile acids on hepatic 3-hydroxy-3-methylglutaryl CoA reductase and cholesterol 7α-hydroxylase in the rat

1973 • 214 citations

Digitonin-collagenase perfusion for efficient separation of periportal or perivenous hepatocytes

1985 • 211 citations

Regulation of bile acid synthesis

1991 • 203 citations

The stuctural and functional unit in the human liver (liver acinus)

1958 • 159 citations

Rat liver cholesterol 7 alpha-hydroxylase. Pretranslational regulation for circadian rhythm.

1990 • 157 citations

Effect of thyroid hormone on hepatic cholesterol 7α hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and apolipoprotein A-I mRNA levels in hypophysectomized rats

1990 • 151 citations

Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution

1982 • 145 citations

A Simplified Method for the Preparation of Transcriptionally Active Liver Nuclear Extracts

1990 • 134 citations

Nychthemeral Variations in Plasma Free Corticosteroid Levels of the Rat.

1959 • 131 citations

Regulation of cholesterol 7 alpha-hydroxylase in the liver. Purification of cholesterol 7 alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7 alpha-hydroxylase by cholestyramine and circadian rhythm.

1990 • 124 citations

The effect of interruption of the enterohepatic circulation of bile acids and of cholesterol feeding on cholesterol 7α-hydroxylase in relation to the diurnal rhythm in its activity

1973 • 116 citations

Autoradiographic and kinetic demonstration of acinar heterogeneity of taurocholate transport

1982 • 115 citations

Regulation of hepatic sterol metabolism in the rat. Parallel regulation of activity and mRNA for 7 alpha-hydroxylase but not 3-hydroxy-3-methylglutaryl-coenzyme A reductase or low density lipoprotein receptor.

1992 • 114 citations

Autoradiographic evidence for hepatic lobular concentration gradient of bile acid derivative

1980 • 99 citations

Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers.

1984 • 99 citations

Hepatic P-450 cholesterol 7 alpha-hydroxylase. Regulation in vivo at the protein and mRNA level in response to mevalonate, diurnal rhythm, and bile acid feedback.

1990 • 85 citations

Physiologic significance and regulation of hepatocellular heterogeneity

1988 • 81 citations

A simplification of the nuclear run-off transcription assay.

1989 • 75 citations

Bile Acid Synthesis in the Isolated, Perfused Rabbit Liver

1971 • 72 citations

Cholesterol and bile acids regulate cholesterol 7 alpha-hydroxylase expression at the transcriptional level in culture and in transgenic mice.

1994 • 72 citations

Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7α-hydroxylase

1994 • 71 citations

Effect of light on corticosterone levels in plasma of rats

1966 • 71 citations

Ribosomal DNA of the fly Sciara coprophila has a very small and homogeneous repeat unit

1979 • 69 citations

Rat‐Liver Cholesterol 7α‐Hydroxylase

1975 • 69 citations

The role of glucocorticoids in the regulation of the diurnal rhythm of hepatic β-hydroxy-β-methylglutaryl-coenzyme A reductase and cholesterol 7α-hydroxylase

1976 • 62 citations

Structure of the rat gene encoding cholesterol 7.alpha.-hydroxylase

1990 • 61 citations

Restricted expression of the erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats. Modulation by glucose.

1990 • 54 citations

Heterogeneity of rat liver parenchyma in cholesterol 7α-hydroxylase and bile acid synthesis

1991 • 49 citations

Transcriptional regulation of the gene encoding cholesterol 7α-hydroxylase in the rat

1993 • 40 citations

Contrôle par les glucocorticostéroïdes de l'activité circadienne de la cholestérol-7α-hydroxylase

1973 • 35 citations

Novel control of the position-dependent expression of genes in hepatocytes. The GLUT-1 transporter.

1993 • 28 citations

Evidence for a specific cytochrome P-450 with short half-life catalyzing 7α-hydroxylation of cholesterol

1981 • 28 citations

The Specificity of the Rat‐Liver Cholesterol 7α‐Hydroxylase

1974 • 28 citations

Portal blood concentraiions of conjugated cholic and chenodeoxycholic acids relationship to bile salt synthesis in liver cells

1981 • 22 citations

Transcriptional rate and steady-state changes of retinoblastoma mRNA in regenerating rat liver

1994 • 13 citations

Role of hepatic glutathione and glucocorticoids in the regulation of hepatic cholesterol 7α-hydroxylase

1986 • 7 citations