Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease

1991 • 2,191 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

A Prospective Study of Plasma Homocyst(e)ine and Risk of Myocardial Infarction in US Physicians

1992 • 1,686 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

1976 • 933 citations

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

1992 • 897 citations

Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine.

1986 • 826 citations

Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis.

1994 • 812 citations

Hyperhomocyst(e)inemia as a Risk Factor for Occlusive Vascular Disease

1992 • 726 citations

Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury

1980 • 489 citations

The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.

1987 • 465 citations

Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine.

1991 • 451 citations

Plasma homocyst(e)ine levels in men with premature coronary artery disease

1990 • 304 citations

Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism.

1992 • 265 citations

Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells.

1989 • 226 citations

Recombinant fragment assay for gene targetting based on the polymerase chain reaction

1988 • 192 citations

Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism.

1993 • 157 citations

Rat cystathionine beta-synthase. Gene organization and alternative splicing.

1992 • 144 citations

Endothelial cell dysfunction in homocystinuria

1983 • 142 citations

Homocysteinemia, ischemic heart disease, and the carrier state for homocystinuria

1983 • 138 citations

Studies on cystathionine synthase of rat liver properties of the highly purified enzyme

1970 • 115 citations

Molecular basis of cystathionine β-synthase deficiency in pyridoxine responsive and nonresponsive homocystinuria

1993 • 98 citations

A study of cardiovascular risk in heterozygotes for homocystinuria.

1981 • 95 citations

Cloning and screening with nanogram amounts of immunopurified mRNAs: cDNA cloning and chromosomal mapping of cystathionine beta-synthase and the beta subunit of propionyl-CoA carboxylase.

1986 • 74 citations

Response of Rats to Diets High in Methionine and Related Compounds

1958 • 56 citations

Plasma Homocysteine and Methionine Tolerance in Early-Onset Vascular Disease

1989 • 29 citations