Allergen-induced Proliferation and Interleukin-5 Production by Bronchoalveolar Lavage and Blood T Cells after Segmental Allergen Challenge

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.

1994 • 850 citations

Allergic and Nonallergic Asthmatics Have Distinct Patterns of T-Cell Activation and Cytokine Production in Peripheral Blood and Bronchoalveolar Lavage

1992 • 788 citations

Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.

1995 • 657 citations

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.

1991 • 641 citations

Activation of CD4+ T cells, increased T-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma

1993 • 593 citations

Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics.

1997 • 416 citations

IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity.

1996 • 413 citations

Allergen exposure induces the activation of allergen‐specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders

1993 • 348 citations

Increases in Activated T Lymphocytes, Eosinophils, and Cytokine mRNA Expression for Interleukin-5 and Granulocyte/Macrophage Colony-stimulating Factor in Bronchial Biopsies after Allergen Inhalation Challenge in Atopic Asthmatics

1993 • 336 citations

IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner.

1990 • 328 citations

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma.

1996 • 309 citations

IL-5-dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity.

1989 • 288 citations

Human atopen-specific types 1 and 2 T helper cell clones.

1991 • 273 citations

T cell responses to the major allergen from the house dust mite Dermatophagoides pteronyssinus, Antigen P1: comparison of patients with asthma, atopic dermatitis, and perennial rhinitis.

1984 • 194 citations

RANTES- and interleukin-8-induced responses in normal human eosinophils: effects of priming with interleukin-5

1994 • 158 citations

IgE-dependent IL-4 secretion by human basophils. The relationship between cytokine production and histamine release in mixed leukocyte cultures.

1994 • 157 citations

IgE-dependent expression of mRNA for IL-4 and IL-5 in human lung mast cells.

1995 • 149 citations

Inhalant allergen‐specific T‐cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum‐free medium

1995 • 126 citations

IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: Relationship to expression of allergic disease

1997 • 122 citations

Secretion of the eosinophil‐active cytokines interleukin‐5, granulocyte/macrophage colonystimulating factor and interleukin‐3 by bronchoalveolar lavage CD4⁺ and CD8⁺ T cell lines in atopics asthmatics, and atopic and nonatopic controls

1995 • 116 citations

In Vitro Synthesis of IL-4 by Human CD4+ T Cells Requires Repeated Antigenic Stimulation

1993 • 66 citations

Frequency of allergen-specific T lymphocytes in blood and bronchial response to allergen in asthma

1993 • 46 citations

Cellular and mediator responses twenty-four hours after local endobronchial allergen challenge of asthmatic airways

1996 • 33 citations

Enhanced detection of human IL-5 in biological fluids utilizing murine monoclonal antibodies which delineate distinct neutralizing epitopes

1994 • 32 citations

Expression of surface antigens distinguishing "naive" and previously activated lymphocytes in bronchoalveolar lavage fluid.

1990 • 31 citations

Peptide specificity and HLA restriction do not dictate lymphokine production by allergen-specific T-lymphocyte clones.

1994 • 31 citations

Expression of terminal deoxynucleotidyl transferase in human thymus during ontogeny and development.

1983 • 26 citations

Extensive apoptosis of lung T-lymphocytes maintained in vitro.

1996 • 24 citations

Allergen-Specific Human T Cell Clones Produce lnterleukin-5 upon Stimulation with the Th1 Cytokine lnterleukin-2

1995 • 22 citations

A clonal analysis of lung T cells derived by bronchoalveolar lavage of healthy individuals.

1992 • 19 citations

Cloning of T Lymphocytes from Bronchoalveolar Lavage Fluid

1992 • 18 citations

Association between late allergic bronchoconstriction in the rat and allergen-stimulated lymphocyte proliferation in vitro.

1995 • 17 citations

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