Analogs of farnesyl pyrophosphate incorporating internal benzoylbenzoate esters: Synthesis, inhibition kinetics and photoinactivation of yeast protein farnesyltransferase

Benzophenone Photophores in Biochemistry

1994 • 835 citations

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1994 • 523 citations

Chemical reagents in photoaffinity labeling

1995 • 277 citations

[15] Synthesis of allylic and homoallylic isoprenoid pyrophosphates

1985 • 205 citations

Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

1993 • 136 citations

Mammalian Protein Geranylgeranyltransferase-I: Substrate Specificity, Kinetic Mechanism, Metal Requirements, and Affinity Labeling

1995 • 122 citations

[4] Continuous fluorescence assay for protein prenyltransferases

1995 • 79 citations

Substrate binding of avian liver prenyltransferase

1976 • 73 citations

Farnesyl transferase inhibitors: the successes and surprises of a new class of potential cancer chemotherapeutics

1995 • 57 citations

Yeast protein farnesyltransferase: steady-state kinetic studies of substrate binding

1995 • 52 citations

Protein farnesyltransferase: production in Escherichia coli and imrmmoaffinity purification of the heterodimer from Saccharomyces cerevisiae

1993 • 45 citations

Photoreactive Analogues of Prenyl Diphosphates as Inhibitors and Probes of Human Protein Farnesyltransferase and Geranylgeranyltransferase Type I

1995 • 42 citations

Photoaffinity labeling of undecaprenyl pyrophosphate synthetase with a farnesyl pyrophosphate analogue.

1985 • 30 citations

Inactivation of undecaprenyl pyrophosphate synthetase with a photolabile analog of farnesyl pyrophosphate

1984 • 20 citations

Inhibition of farnesyl transferases from malignant and non-malignant cultured human lymphocytes by prenyl substrate analogues

1991 • 18 citations