An Integrated Metabonomic Investigation of Acetaminophen Toxicity in the Mouse Using NMR Spectroscopy

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

1999 • 3,649 citations

MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy

1985 • 3,603 citations

Metabonomics: a platform for studying drug toxicity and gene function

2002 • 1,871 citations

Computer-optimized decoupling scheme for wideband applications and low-level operation

1985 • 1,104 citations

Orthogonal signal correction of near-infrared spectra

1998 • 1,038 citations

750 MHz 1H and 1H-13C NMR Spectroscopy of Human Blood Plasma

1995 • 1,004 citations

Sensitivity enhanced detection of weak nuclei using heteronuclear multiple quantum coherence

1979 • 911 citations

Validation and development of fluorescence two-dimensional differential gel electrophoresis proteomics technology

2001 • 883 citations

Acute liver necrosis following overdose of paracetamol.

1966 • 525 citations

Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids

2000 • 465 citations

Pattern recognition methods and applications in biomedical magnetic resonance

2001 • 418 citations

LIVER NECROSIS FROM PARACETAMOL

1966 • 304 citations

Genomics and Proteomics Analysis of Acetaminophen Toxicity in Mouse Liver

2002 • 303 citations

Nuclear Magnetic Resonance Spectroscopic and Principal Components Analysis Investigations into Biochemical Effects of Three Model Hepatotoxins

1998 • 267 citations

Renal necrosis, glutathione depletion, and covalent binding after acetaminophen

1978 • 222 citations

NMR and Pattern Recognition Studies on the Time-Related Metabolic Effects of α-Naphthylisothiocyanate on Liver, Urine, and Plasma in the Rat: An Integrative Metabonomic Approach

2001 • 198 citations

High-resolution1H and1H-13C magic angle spinning NMR spectroscopy of rat liver

2000 • 165 citations

Free radical–induced megamitochondria formation and apoptosis

1999 • 146 citations

Gradient, high‐resolution, magic angle spinning ¹H nuclear magnetic resonance spectroscopy of intact cells

1998 • 144 citations

Gradient, high‐resolution, magic‐angle spinning nuclear magnetic resonance spectroscopy of human adipocyte tissue

1997 • 128 citations

High‐resolution ¹H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2‐bromoethanamine in intact renal and hepatic tissue

2001 • 96 citations

Acetaminophen-induced hepatic injury in mice: The role of lipid peroxidation and effects of pretreatment with coenzyme Q10 and α-tocopherol

1995 • 88 citations

Paracetamol Overdose in Man: Relationship between Pattern of Urinary Metabolites and Severity of Liver Damage

1976 • 82 citations

Acute renal failure associated with acetaminophen ingestion: report of a case and review of the literature.

1980 • 79 citations

Alanine Aminotransferase

1967 • 71 citations

Phospholipid identification and quantification of membrane vesicle subfractions by³¹P−¹H two‐dimensional nuclear magnetic resonance

2000 • 44 citations

Systemic alterations in phospholipid concentrations of blood plasma in patients with thyroid carcinoma: anin-vitro31P high-resolution NMR study

2000 • 37 citations

Pathways of disposition of acetaminophen conjugates in the mouse☆

1981 • 37 citations