The Impact of Metformin, Oral Contraceptives, and Lifestyle Modification on Polycystic Ovary Syndrome in Obese Adolescent Women in Two Randomized, Placebo-Controlled Clinical Trials
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Abstract
References (50)
Prevalence of Overweight and Obesity in the United States, 1999-2004
2006 • 8,878 citations
Abdominal obesity and metabolic syndrome
2006 • 4,004 citations
The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
2004 • 2,625 citations
Prevalence of a Metabolic Syndrome Phenotype in Adolescents
2003 • 2,295 citations
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
1989 • 1,858 citations
Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome
2007 • 981 citations
Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome
1992 • 908 citations
Metformin in polycystic ovary syndrome: systematic review and meta-analysis
2003 • 775 citations
Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women
1995 • 647 citations
Effects of Lifestyle Activity vs Structured Aerobic Exercise in Obese Women<SUBTITLE>A Randomized Trial</SUBTITLE>
1999 • 630 citations
Fasting Triglycerides, High-Density Lipoprotein, and Risk of Myocardial Infarction
1997 • 606 citations
Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay
1988 • 538 citations
Adolescent Overweight and Future Adult Coronary Heart Disease
2007 • 526 citations
Evidence for Association Between Polycystic Ovary Syndrome and Premature Carotid Atherosclerosis in Middle-Aged Women
2000 • 515 citations
Restoration of Reproductive Potential by Lifestyle Modification in Obese Polycystic Ovary Syndrome: Role of Insulin Sensitivity and Luteinizing Hormone1
1999 • 475 citations
Epidemiology and Adverse Cardiovascular Risk Profile of Diagnosed Polycystic Ovary Syndrome
2006 • 378 citations
Impact of Obesity on the Risk for Polycystic Ovary Syndrome
2007 • 376 citations
Overweight and obese anovulatory patients with polycystic ovaries: parallel improvements in anthropometric indices, ovarian physiology and fertility rate induced by diet
2003 • 345 citations
Ovarian Function and Metabolic Factors in Women with Oligomenorrhea Treated with Metformin in a Randomized Double Blind Placebo-Controlled Trial
2002 • 342 citations
The role of lifestyle modification in polycystic ovary syndrome
2002 • 328 citations
Development of polycystic ovary syndrome: involvement of genetic and environmental factors
2005 • 295 citations
A randomized, 48-week, placebo-controlled trial of intensive lifestyle modification and/or metformin therapy in overweight women with polycystic ovary syndrome: A pilot study
2004 • 270 citations
Overweight Women with Polycystic Ovary Syndrome Have Evidence of Subclinical Cardiovascular Disease
2005 • 269 citations
Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay
1988 • 262 citations
Obesity and Sex Steroid Changes across Puberty: Evidence for Marked Hyperandrogenemia in Pre- and Early Pubertal Obese Girls
2006 • 240 citations
Overweight and obesity from childhood to adulthood: a follow‐up of participants in the 1985 Australian Schools Health and Fitness Survey
2007 • 239 citations
Altered Vascular Function in Young Women with Polycystic Ovary Syndrome
2002 • 236 citations
Increased Endothelin-1 Levels in Women with Polycystic Ovary Syndrome and the Beneficial Effect of Metformin Therapy
2001 • 232 citations
Type 2 Diabetes Mellitus in Children
2001 • 182 citations
Ethinylestradiol-Drospirenone, Flutamide-Metformin, or Both for Adolescents and Women with Hyperinsulinemic Hyperandrogenism: Opposite Effects on Adipocytokines and Body Adiposity
2004 • 173 citations
The Association of Obesity and Hyperandrogenemia during the Pubertal Transition in Girls: Obesity as a Potential Factor in the Genesis of Postpubertal Hyperandrogenism
2006 • 172 citations
Cardiovascular disease in the polycystic ovary syndrome: New insights and perspectives
2005 • 163 citations
A Comparison of Lipid Variables as Predictors of Cardiovascular Disease in the Asia Pacific Region
2005 • 149 citations
The triglyceride/HDL-cholesterol ratio as a marker of cardiovascular risk in obese children; association with traditional and emergent risk factors
2008 • 148 citations
Insulin Resistance, the Metabolic Syndrome, Diabetes, and Cardiovascular Disease Risk in Women with PCOS
2006 • 138 citations
Androgen and lipid profiles in adolescents with polycystic ovary syndrome who were treated with two forms of combined oral contraceptives
2002 • 136 citations
Body Size and Shape Changes and the Risk of Diabetes in the Diabetes Prevention Program
2007 • 124 citations
Effects of two forms of combined oral contraceptives on carbohydrate metabolism in adolescents with polycystic ovary syndrome
2006 • 102 citations
Role of lifestyle modification in the management of polycystic ovary syndrome
2006 • 92 citations
Randomized Controlled Trial Evaluating Response to Metformin Versus Standard Therapy in the Treatment of Adolescents with Polycystic Ovary Syndrome
2005 • 90 citations
Cardiometabolic features of polycystic ovary syndrome
2008 • 87 citations
Combined Effects of HDL Cholesterol, Triglyceride, and Total Cholesterol Concentrations on 18-Year Risk of Atherosclerotic Disease
1995 • 81 citations
Obesity—A Critical Issue in Preventive Cardiology: The Bogalusa Heart Study
2005 • 71 citations
Effects of Third-Generation Oral Contraceptives on High-Sensitivity C-reactive Protein and Homocysteine in Young Women
2008 • 68 citations
Body Mass Index in Adolescence and Number of Children in Adulthood
2007 • 59 citations
Oral Contraceptives in Polycystic Ovary Syndrome: Risk-Benefit Assessment
2008 • 51 citations
Combined Oral Contraceptive Treatment of Adolescent Girls with Polycystic Ovary Syndrome: Lipid Profile
2000 • 46 citations
Metformin Beyond Diabetes: New Life for an Old Drug
2006 • 43 citations
Oral Contraceptives and the Management of Hyperandrogenism–Polycystic Ovary Syndrome in Adolescents
2005 • 36 citations
Which Treatment Options Should Be Used in Adolescents with Polycystic Ovary Syndrome?
2004 • 5 citations