Development of a DNA probe from the deoxyribonucleotide sequence of a 3-N-aminoglycoside acetyltransferase [AAC(3)-I] resistance gene

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Antibiotic Susceptibility Testing by a Standardized Single Disk Method

1966 • 18,209 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Nonchromosomal Antibiotic Resistance in Bacteria: Genetic Transformation of Escherichia coli by R-Factor DNA

1972 • 2,842 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.

1987 • 2,266 citations

Simple method for identification of plasmid-coded proteins

1979 • 1,054 citations

DNA: Insertion Elements, Plasmids, and Episomes.

1977 • 530 citations

The GenBank genetic sequence databank

1986 • 464 citations

Plasmid-Determined Resistance to Antimicrobial Agents

1978 • 437 citations

The protein identification resource (PIR)

1988 • 389 citations

[48] Aminoglycoside-modifying enzymes

1975 • 327 citations

The EMBL data library.

1988 • 314 citations

Plasmid vector pBR322 and its special-purpose derivatives — a review

1986 • 311 citations

Site-specific recombination promotes linkage between trimethoprim- and sulfonamide resistance genes. Sequence characterization of dhfrV and sulI and a recombination active locus of Tn21

1988 • 252 citations

Diagnostic deoxyribonucleic acid probes for infectious diseases

1988 • 244 citations

Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene.

1987 • 228 citations

Nucleotide sequence analysis of a gene encoding a streptomycin/spectinomycin adenyltransferase

1985 • 204 citations

Structure-independent nucleotide sequence analysis.

1979 • 199 citations

Nucleotide sequence of the AAD(2′) aminoglycoside adenylyltransferase determinantaadB. Evolutionary relationship of this region with those surroundingaadAin R538-1 anddhfrllin R388

1986 • 164 citations

Sequence of PSE-2 beta-lactamase

1988 • 156 citations

Nucleotide sequence of thetetMtetracycline resistance determinant of the streptococcal conjugative shuttle transposon Tn1545

1986 • 156 citations

A program for prediction of protein secondary structure from nucleotide sequence data: application to histocompatibility antigens

1984 • 150 citations

Comparison of aminoglycoside resistance patterns in Japan, Formosa, and Korea, Chile, and the United States

1985 • 125 citations

Distribution of erythromycin esterase and rRNA methylase genes in members of the family Enterobacteriaceae highly resistant to erythromycin

1987 • 123 citations

The region of the incN plasmid R46 coding for resistance to β-lactam antibiotics, streptomycin/spectinomycin and sulphonamides is closely related to antibiotic resistance segments found In IncW plasm ids and in Tn21-like transposons

1987 • 121 citations

Nucleotide sequence and distribution of genetetOencoding tetracycline resistance inCampylobacter coli

1987 • 116 citations

Gentamicin resistance in strains of Pseudomonas aeruginosa mediated by enzymic N-acetylation of the deoxystreptamine moiety

1972 • 113 citations

Genes for gentamicin-(3)-N-acetyltransferases III and IV:

1984 • 104 citations

Nucleotide sequence of the transposon Tn7 gene encoding an aminoglycoside-modifying enzyme, 3″(9)-O-nucleotidyltransferase

1985 • 87 citations

DNA sequence of a plasmid-encoded dihydrofolate reductase

1981 • 82 citations

Primary structure of an aminoglycoside 6'-N-acetyltransferase AAC(6')-4, fused in vivo with the signal peptide of the Tn3-encoded beta-lactamase

1987 • 81 citations

Survey of aminoglycoside resistance patterns.

1986 • 80 citations

Sequential Hospitalwide Outbreaks of Resistant Serratia and Klebsiella Infections

1977 • 73 citations

Insertion Sequence Duplication in Transpositional Recombination

1983 • 73 citations

Cloning and sequencing of a gene encoding an aminoglycoside 6'-N-acetyltransferase from an R factor of Citrobacter diversus

1988 • 72 citations

Evolution of multiple-antibiotic-resistance plasmids mediated by transposable plasmid deoxyribonucleic acid sequences

1979 • 71 citations

Plasmid-mediated tetracycline resistance in Campylobacter jejuni: expression in Escherichia coli and identification of homology with streptococcal class M determinant

1986 • 69 citations

Genes for gentamicin-(3)-N-acetyl-transferases III and IV

1985 • 60 citations

Effect of Enzymatic Adenylylation on Dihydrostreptomycin Accumulation in Escherichia coli Carrying an R-Factor: Model Explaining Aminoglycoside Resistance by Inactivating Mechanisms

1978 • 59 citations

Characterization of a R plasmid-associated, trimethoprim-resistant dihydrofolate reductase and determination of the nucleotide sequence of the reductase gene

1981 • 57 citations

Characteristics of Serratia marcescens Containing a Plasmid Coding for Gentamicin Resistance in Nosocomial Infections

1981 • 53 citations

Enzymatic Modification of Aminoglycoside Antibiotics: a New 3- N -Acetylating Enzyme from a Pseudomonas aeruginosa Isolate

1976 • 53 citations

Nudeotide sequence analysis of tbe trimethoprim resistant dihydrofolate reductase encoded by R plasmid R751

1986 • 49 citations

Studies of antimicrobial resistance genes using DNA probes

1986 • 49 citations

Detection of plasmid-mediated beta-lactamases with DNA probes

1988 • 48 citations

Characterization of Tn2411 and Tn2410, two transposons derived from R-plasmid R1767 and related to Tn2603 and Tn21

1983 • 48 citations

Development of a DNA Probe for the Structural Gene of the 2''-O-Adenyltransferase Aminoglycoside-Modifying Enzyme

1984 • 39 citations

Characterization of transferable plasmids from Shigella flexneri 2a that confer resistance to trimethoprim, streptomycin, and sulfonamides

1986 • 39 citations

The role of insertions, deletions, and substitutions in the evolution of R6 related plasmids encoding aminoglycoside transferase ANT-(2″)

1984 • 36 citations

Development of two DNA probes for differentiating the structural genes of subclasses I and II of the aminoglycoside-modifying enzyme 3'-aminoglycoside phosphotransferase

1985 • 34 citations

Proposal for a Rational Nomenclature for Phenotype, Genotype and Aminoglycoside-Aminocyclitol Modifying Enzymes

1975 • 23 citations

PLASMID-MEDIATED GENTAMIGIN RESISTANCE NOT ASSOCIATED WITH KANAMYCIN RESISTANCE IN ENTEROBACTERIACEAE

1972 • 21 citations

Outbreaks of hospital infection in southwest England caused by gentamicin-resistant Serratia marcescens

1982 • 21 citations

Nucleic acid hybridisation with a probe specific for 3 aminoglycoside acetyltransferase type IV: A survey of resistance to apramycin and gentamicin in animal strains ofEscherichia coli

1986 • 18 citations

Comparison of three DNA hybridization methods for detection of the aminoglycoside 2"-O-adenylyltransferase gene in clinical bacterial isolates

1985 • 18 citations

Enzymatic modification of aminocyclitol antibiotics: Mutations affecting the expression of aminocyclitol acetyltransferase-3

1980 • 10 citations

NH₂‐terminal sequence of the aminoglycoside acetyltransferase (3)‐I mediated by plasmid RIP 135

1978 • 8 citations