Inhibition of Purine Nucleoside Phosphorylase by 8-Aminoguanosine: Selective Toxicity for T Lymphoblasts

ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY

1972 • 1,654 citations

NUCLEOSIDE-PHOSPHORYLASE DEFICIENCY IN A CHILD WITH SEVERELY DEFECTIVE T-CELL IMMUNITY AND NORMAL B-CELL IMMUNITY

1975 • 855 citations

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.

1978 • 399 citations

Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency.

1978 • 277 citations

Apparent suicide inactivation of human lymphoblast S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine and adenine arabinoside. A basis for direct toxic effects of analogs of adenosine.

1979 • 277 citations

Combined immunodeficiency disease associated with adenosine deaminase deficiency

1975 • 255 citations

Deoxyguanosine Triphosphate as a Possible Toxic Metabolite in the Immunodeficiency Associated with Purine Nucleoside Phosphorylase Deficiency

1978 • 215 citations

Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells.

1978 • 209 citations

Purine Nucleoside Phosphorylase Deficiency Associated with Selective Cellular Immunodeficiency

1977 • 197 citations

Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines.

1979 • 176 citations

Differential Sensitivity of Human Leukemic T Cell Lines and B Cell Lines to Growth Inhibition by Deoxyadenosine

1978 • 167 citations

Isolation and characterization of purine-nucleoside phosphorylase-deficient T-lymphoma cells and secondary mutants with altered ribonucleotide reductase: Genetic model for immunodeficiency disease

1979 • 158 citations

Purine Nucleosides. IX. The Synthesis of 9-β-D-Ribofuranosyl Uric Acid and Other Related 8-Substituted Purine Ribonucleosides¹

1965 • 144 citations

The potential importance of soluble deoxynucleotidase activity in mediating deoxyadenosine toxicity in human lymphoblasts.

1981 • 144 citations

Molecular form of adenosine deaminase in severe combined immunodeficiency

1974 • 105 citations

Biochemical basis for differential deoxyadenosine toxicity to T and B lymphoblasts: role for 5'-nucleotidase.

1979 • 99 citations

Inhibitors of purine nucleoside phosphorylase

1982 • 90 citations

Inhibition of adenosine deaminase activity results in cytotoxicity to T lymphoblasts in vivo

1980 • 75 citations

Purine nucleoside phosphorylase from human erythrocytes. 3. Inhibition by the inosine analog formycin B of the isolated enzyme and of nucleoside metabolism in intact erythrocytes and sarcoma 180 cells.

1968 • 68 citations

Purine nucleoside phosphorylase deficiency: altered kinetic properties of a mutant enzyme

1977 • 56 citations

Inhibition of adenosine deaminase activity results in cytotoxicity to T lymphoblasts in vivo

1980 • 53 citations

Purinogenic Immunodeficiency Diseases

1979 • 52 citations

An assay of deoxyadenosine and adenosine in human plasma by HPLC

1980 • 30 citations