Sedation and analgesia in the critically ill adult

Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult

2002 • 1,858 citations

Lorazepam Is an Independent Risk Factor for Transitioning to Delirium in Intensive Care Unit Patients

2005 • 1,161 citations

Assessing pain in critically ill sedated patients by using a behavioral pain scale

2001 • 956 citations

The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome

2003 • 562 citations

Impact of systematic evaluation of pain and agitation in an intensive care unit*

2006 • 494 citations

Patients' perceptions and responses to procedural pain: results from Thunder Project II

2001 • 362 citations

ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens

2003 • 339 citations

Selective Postoperative Inhibition of Gastrointestinal Opioid Receptors

2001 • 323 citations

A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients*

2006 • 310 citations

Methylnaltrexone for Reversal of Constipation Due to Chronic Methadone Use

2000 • 298 citations

Alvimopan, a Novel, Peripherally Acting μ Opioid Antagonist

2004 • 298 citations

Validation of a Behavioral Pain Scale in Critically Ill, Sedated, and Mechanically Ventilated Patients

2005 • 254 citations

Relationship between behavioral and physiological indicators of pain, critical care patients' self-reports of pain, and opioid administration

1997 • 233 citations

Decreased duration of mechanical ventilation when comparing analgesia-based sedation using remifentanil with standard hypnotic-based sedation for up to 10 days in intensive care unit patients: a randomised trial [ISRCTN47583497].

2005 • 221 citations

Bispectral index-guided sedation with dexmedetomidine in intensive care: A prospective, randomized, double blind, placebo-controlled phase II study*

2002 • 205 citations

Dexmedetomidine infusion for more than 24 hours in critically ill patients: sedative and cardiovascular effects

2004 • 197 citations

Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308].

2004 • 187 citations

A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit

2003 • 185 citations

Propylene Glycol Toxicity: A Severe Iatrogenic Illness in ICU Patients Receiving IV Benzodiazepines

2005 • 165 citations

Remifentanil versus fentanyl for analgesia based sedation to provide patient comfort in the intensive care unit: a randomized, double-blind controlled trial [ISRCTN43755713].

2003 • 158 citations

Sedative and Analgesic Medications: Risk Factors for Delirium and Sleep Disturbances in the Critically Ill

2006 • 154 citations

Frequency, Severity, and Treatment of Agitation in Young versus Elderly Patients in the ICU

2000 • 153 citations

Remifentanil versus Morphine Analgesia and Sedation for Mechanically Ventilated Critically Ill Patients

2004 • 138 citations

Metabolic Acidosis Associated with Propofol in the Absence of Other Causative Factors

2004 • 92 citations

Osmol Gap as a Surrogate Marker for Serum Propylene Glycol Concentrations in Patients Receiving Lorazepam for Sedation

2006 • 72 citations

Removal of propylene glycol and correction of increased osmolar gap by hemodialysis in a patient on high dose lorazepam infusion therapy

2001 • 70 citations

Addition of Dexmedetomidine to Standard Sedation Regimens After Cardiac Surgery: An Outcomes Analysis

2006 • 65 citations

Comparing Dexmedetomidine Prescribing Patterns and Safety in the Naturalistic Setting Versus Published Data

2004 • 64 citations

Lactic Acidosis during Propofol–Remifentanil Anesthesia in an Adult

2004 • 61 citations