Detection of an Activating Mutation of the Thyrotropin Receptor in a Case of an Autonomously Hyperfunctioning Thyroid Insular Carcinoma1

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1993 • 907 citations

Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor

1989 • 523 citations

Poorly Differentiated Insular Thyroid Carcinoma

1998 • 393 citations

Increased Aggressiveness of Thyroid Cancer in Patients with Graves' Disease*

1990 • 288 citations

Somatic and germline mutations of the TSH receptor gene in thyroid diseases.

1995 • 244 citations

Expression of thyroid-specific transcription factors TTF-1 and PAX-8 in human thyroid neoplasms.

1994 • 237 citations

gsp mutations in human thyroid tumours.

1991 • 198 citations

Poorly Differentiated Thyroid Carcinomas with Primordial Cell Component

1993 • 188 citations

The Role of Thyroid-Stimulating Antibodies of Graves' Disease in Differentiated Thyroid Cancer

1988 • 172 citations

Activating point mutations of the gsp oncogene in human thyroid adenomas

1991 • 168 citations

Activating mutations of the TSH receptor in differentiated thyroid carcinomas.

1995 • 139 citations

Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroid.

1994 • 128 citations

Thyrotropin receptor gene alterations in thyroid hyperfunctioning adenomas.

1996 • 119 citations

Novel mutations of thyrotropin receptor gene in thyroid hyperfunctioning adenomas. Rapid identification by fine needle aspiration biopsy.

1994 • 116 citations

Poorly differentiated ("insular") carcinoma of the thyroid gland: an aggressive subset of differentiated thyroid neoplasms.

1988 • 112 citations

Genetic alterations in thyroid hyperfunctioning adenomas.

1995 • 110 citations

Oncogenes and anti-oncogenes in human epithelial thyroid tumors

1994 • 61 citations

Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas.

1996 • 47 citations

Constitutive activation of cyclic AMP but not phosphatidylinositol signaling caused by four mutations in the 6th transmembrane helix of the human thyrotropin receptor

1994 • 44 citations

The management of thyroid nodules

1995 • 23 citations

Thyroid cancer presenting as a hot thyroid nodule: report of a case and review of the literature.

1988 • 16 citations

Thyroid hormone-producing metastases in differentiated thyroid cancer

1996 • 15 citations

Jodinduzierte T3- Hyperthyreose beim metastasierenden follikulären Schilddrüsenkarzinom

1986 • 7 citations

Thyroid-stimulating hormone receptor gene mutations and polymorphisms in thyroid disease

1996 • 6 citations