Glucoregulation during exercise: hypoglycemia is prevented by redundant glucoregulatory systems, sympathochromaffin activation, and changes in islet hormone secretion.

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

1979 • 7,240 citations

Immunoassay of insulin with insulin-antibody precipitate

1963 • 2,632 citations

Effect of Ischemia on Known Substrates and Cofactors of the Glycolytic Pathway in Brain

1964 • 2,227 citations

Norepinephrine and Epinephrine Release and Adrenergic Mediation of Smoking-Associated Hemodynamic and Metabolic Events

1976 • 1,114 citations

Hormone-fuel interrelationships during fasting.

1966 • 1,032 citations

Colorimetric ultramicro method for the determination of free fatty acids

1965 • 656 citations

A Sensitive Double Antibody Immunoassay for Human Growth Hormone in Plasma

1964 • 645 citations

Determination of Free and Total Insulin and C-Peptide in Insulin-treated Diabetics

1977 • 593 citations

Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man.

1980 • 588 citations

Epinephrine-induced Insulin Resistance in Man

1980 • 546 citations

Role of Glucagon, Catecholamines, and Growth Hormone in Human Glucose Counterregulation

1979 • 417 citations

Identification of Type I Diabetic Patients at Increased Risk for Hypoglycemia during Intensive Therapy

1983 • 394 citations

Sympathetic Nervous Activity During Exercise

1983 • 367 citations

The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man.

1976 • 350 citations

Adrenergic Mechanisms for the Effects of Epinephrine on Glucose Production and Clearance in Man

1980 • 341 citations

Norepinephrine: hormone and neurotransmitter in man.

1978 • 339 citations

Glucose Counterregulation, Hypoglycemia, and Intensive Insulin Therapy in Diabetes Mellitus

1985 • 277 citations

Glucose Counterregulation in Man

1981 • 268 citations

Measurement of total and organ-specific norepinephrine kinetics in humans

1984 • 265 citations

Hypoglycemia during Prolonged Exercise in Normal Men

1982 • 211 citations

Afferent and efferent neural roles in liver function

1983 • 205 citations

Effects of 12 months of intense exercise training on ischemic ST-segment depression in patients with coronary artery disease.

1981 • 200 citations

Enzymic assay of glycerol, dihydroxyacetone, and glyceraldehyde

1967 • 199 citations

Hormonal mechanisms of recovery from insulin-induced hypoglycemia in man.

1979 • 183 citations

Inhibitory Effect of Epinephrine on Insulin-stimulated Glucose Uptake by Rat Skeletal Muscle

1981 • 177 citations

Plasma Cortisol Determination: Radioimmunoassay and Competitive Protein Binding Compared

1974 • 174 citations

Glucagon and plasma catecholamines during beta-receptor blockade in exercising man

1976 • 174 citations

Physiological Concentrations of Growth Hormone Exert Insulin-Like and Insulin Antagonistic Effects on Both Hepatic and Extrahepatic Tissues in Man*

1981 • 173 citations

Measurement of Norepinephrine and Epinephrine in Small Volumes of Human Plasma by a Single Isotope Derivative Method: Response to the Upright Posture

1974 • 160 citations

Glucoregulation During Moderate Exercise in Insulin Treated Diabetics

1977 • 156 citations

Direct Control of Glycogen Metabolism in the Perfused Rat Liver by the Sympathetic Innervation

1982 • 152 citations

Epinephrine and norepinephrine are cleared through beta-adrenergic, but not alpha-adrenergic, mechanisms in man

1980 • 119 citations

Physical exercise and fuel homeostasis in diabetes mellitus

1978 • 117 citations

Differential effects of epinephrine on glucose production and disposal in man.

1979 • 116 citations

Interactions between glucagon and other counterregulatory hormones during normoglycemic and hypoglycemic exercise in dogs.

1984 • 114 citations

Role of Epinephrine-mediated β-Adrenergic Mechanisms in Hypoglycemic Glucose Counterregulation and Posthypoglycemic Hyperglycemia in Insulin-dependent Diabetes Mellitus

1982 • 110 citations

Effects of 12 months of intense exercise training on ischemic ST-segment depression in patients with coronary artery disease.

1981 • 103 citations

Diabetes and exercise

1981 • 98 citations

Heterogeneity of plasma glucagon immunoreactivity in normal, depancreatized, and alloxan-diabetic dogs

1975 • 90 citations

The Effect of Somatostatin on Glucose Uptake and Production by Rat Tissues in Vitro

1977 • 86 citations

Enhanced glycemic responsiveness to epinephrine in insulin-dependent diabetes mellitus is the result of the inability to secrete insulin. Augmented insulin secretion normally limits the glycemic, but not the lipolytic or ketogenic, response to epinephrine in humans.

1985 • 81 citations

Catecholamines and Pancreatic Hormones during Autonomic Blockade in Exercising Man

1977 • 79 citations

Mechanisms of postprandial glucose counterregulation in man. Physiologic roles of glucagon and epinephrine vis-a-vis insulin in the prevention of hypoglycemia late after glucose ingestion.

1983 • 75 citations

Effect of epinephrine on glycogenolysis and gluconeogenesis in conscious overnight-fasted dogs

1984 • 74 citations

Adrenergic mechanisms in recovery from hypoglycemia in man: adrenergic blockade.

1979 • 74 citations

Immunoassays for Glucagon

1983 • 72 citations

Neuroendocrine responses to glucose ingestion in man. Specificity, temporal relationships, and quantitative aspects

1983 • 67 citations

Adrenergic blockade alters glucose kinetics during exercise in insulin-dependent diabetics.

1984 • 62 citations

Adrenal medullary control of muscular and hepatic glycogenolysis and of pancreatic hormonal secretion in exercising rats

1980 • 62 citations

The glycogenolytic response to stimulation of the splanchnic nerves in adrenalectomized calves, sheep, dogs, cats and pigs

1971 • 61 citations

The role of the adrenergic innervation to the pancreatic islets in the control of insulin release during exercise in man

1979 • 53 citations

Role of Insulin and Glucagon in the Regulation of Hepatic Glucose Production During Exercise

1979 • 48 citations

Organization and function of the sympathetic innervation.

1977 • 47 citations

The sensitivity of the hepatic glycogenolytic mechanism to stimulation of the splanchnic nerves

1972 • 43 citations

Role of epinephrine for muscular glycogenolysis and pancreatic hormonal secretion in running rats

1981 • 40 citations

Epinephrine supports the postabsorptive plasma glucose concentration and prevents hypoglycemia when glucagon secretion is deficient in man.

1984 • 40 citations

Roles of glucagon and epinephrine in hypoglycemic and nonhypoglycemic glucose counterregulation in humans

1984 • 39 citations

On the sympathetic innervation to the cat's liver and its role for hepatic glucose release

1980 • 38 citations

Role of glucagon in regulation of glucose production in exercising dogs

1980 • 36 citations

Control of hepatic glucose output by glucagon and insulin in the intact dog.

1978 • 35 citations

Transhepatic Glucagon Gradients in Man: Evidence for Glucagon Extraction by Human Liver*

1984 • 30 citations

Does Central Nervous System Adaptation to Antecedent Glycemia Occur in Patients with Insulin-Dependent Diabetes Mellitus?

1985 • 28 citations

β‐adrenoceptor blockade and exercise: effects on endurance and physical training

1983 • 28 citations

Correlation between endogenous noradrenaline and glucose released from the liver upon hepatic sympathetic nerve stimulation in anesthetized dogs

1984 • 22 citations

Influence of hypoglucagonemia on splanchnic glucose output during leg exercise in man

1981 • 20 citations

Portal and peripheral vein concentrations of insulin and glucagon after arginine infusion in morbidly obese subjects

1980 • 20 citations

Somatostatin: its role in health and disease.

1982 • 20 citations

The Effect of Hyperinsulinemia on Glucose Homeostasis During Moderate Exercise in Man

1982 • 20 citations

Interference of immunoglobulins in two glucagon radioimmunoassays.

1982 • 20 citations

Failure of somatostatin to modify effect of glucagon on carbohydrate metabolism in the dog

1983 • 17 citations

Exercise in diabetic man: glucose turnover and free insulin responses after glycemic normalization with intravenous insulin

1982 • 16 citations

Absence of exercise-induced hypoglycaemia in Type I (insulin-dependent) diabetic patients during maintenance of normoglycaemia by short-term, open-loop insulin infusion

1982 • 14 citations

Effect of adrenal denervation on the glucose, insulin, and glucagon responses to exercise in sheep

1982 • 10 citations

Lack of effect of somatostatin on the stimulation of hepatic glycogenolysis by epinephrine in isolated canine hepatocytes

1984 • 9 citations

Plasma catecholamines and response to exercise in 6-hydroxydopamine-treated dogs

1982 • 6 citations