Prostaglandins as Inhibitors of Human Platelet Aggregation

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.

1975 • 856 citations

The chemical structure of prostaglandin X (prostacyclin)

1976 • 729 citations

Modulation of human platelet adenylate cyclase by prostacyclin (PGX)

1977 • 659 citations

Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets

1977 • 601 citations

Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species

1978 • 339 citations

Arachidonic acid-induced human platelet aggregation and prostaglandin formation

1973 • 279 citations

Prostaglandin D2 inhibits the aggregation of human platelets

1974 • 230 citations

Stimulation of human platelet adenylate cyclase by prostaglandin D2

1974 • 170 citations

Prostacyclin increases cyclic AMP levels and adenylate cyclase activity in platelets

1977 • 144 citations

Biosynthesis of prostaglandin D2 1. Formation of prostaglandin D2 by human platelets

1977 • 140 citations

Divergent effects of epinephrine and prostaglandin E1 on the level of cyclic AMP in human blood platelets

1969 • 118 citations

Discrimination between platelet prostaglandin receptors with a specific antagonist of bisenoic prostaglandins

1977 • 59 citations

Effect of prostaglandin I2 and analogs on platelet aggregation and smooth muscle contraction.

1978 • 18 citations