Angiotensin and its AT2 receptor: new insights into an old system

Angiotensin II receptors and angiotensin II receptor antagonists.

1993 • 1,843 citations

The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.

1995 • 918 citations

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

1995 • 858 citations

Identification of angiotensin II receptor subtypes

1989 • 825 citations

Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.

1993 • 767 citations

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

1995 • 740 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.

1993 • 713 citations

Angiotensin II type 2 receptor mediates programmed cell death.

1996 • 707 citations

The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.

1995 • 688 citations

Regulation of growth cone behavior by calcium

1991 • 597 citations

Expression of AT2 receptors in the developing rat fetus.

1991 • 537 citations

Pathophysiological Role of Angiotensin II Type 2 Receptor in Cardiovascular and Renal Diseases

1998 • 485 citations

Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction.

1995 • 441 citations

AT ₂ Receptor Stimulation Increases Aortic Cyclic GMP in SHRSP by a Kinin-Dependent Mechanism

1998 • 393 citations

Angiotensin II Induces Apoptosis of Human Endothelial Cells

1997 • 363 citations

Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain

1991 • 342 citations

Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2.

1994 • 329 citations

Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT ₂ ) angiotensin receptor

1999 • 316 citations

The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.

1996 • 311 citations

Mapping of angiotensin II receptor subtype heterogeneity in rat brain

1992 • 308 citations

Opposing Actions of Angiotensin II on Microvascular Growth and Arterial Blood Pressure

1996 • 287 citations

The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase

1992 • 252 citations

Angiotensin Type 2 Receptors Are Reexpressed by Cardiac Fibroblasts From Failing Myopathic Hamster Hearts and Inhibit Cell Growth and Fibrillar Collagen Metabolism

1997 • 250 citations

Angiotensin II in central nervous system physiology

1998 • 247 citations

Protective Role of the Angiotensin AT ₂ Receptor in a Renal Wrap Hypertension Model

1999 • 241 citations

Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure.

1996 • 230 citations

The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells

1996 • 229 citations

Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase

1997 • 225 citations

The Angiotensin II Type 2 (AT2) Receptor Promotes Axonal Regeneration in the Optic Nerve of Adult Rats

1998 • 209 citations

Signal Transduction from the Angiotensin II AT2 Receptor

2000 • 208 citations

Changes in expression of angiotensin receptor subtypes in the rat aorta during development

1991 • 203 citations

Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II.

1994 • 197 citations

Mitogen-activated Protein Kinases in Rat Brain Neuronal Cultures Are Activated by Angiotensin II Type 1 Receptors and Inhibited by Angiotensin II Type 2 Receptors

1996 • 191 citations

Angiotensin II Induction of Neurite Outgrowth by AT2 Receptors in NG108-15 Cells

1996 • 185 citations

Angiotensin-converting enzyme inhibition improves cardiac function. Role of bradykinin.

1994 • 185 citations

Differential distribution of AT1 and AT2 angiotensin II receptor subtypes in the rat brain during development.

1991 • 184 citations

Autoradiographic localization of subtypes of angiotensin II antagonist binding in the rat brain

1991 • 173 citations

Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction Rapid Communication

1998 • 170 citations

Paracrine Systems in the Cardioprotective Effect of Angiotensin-Converting Enzyme Inhibitors on Myocardial Ischemia/Reperfusion Injury in Rats

1996 • 142 citations

Inflammation influences vascular remodeling through AT₂receptor expression and signaling

2000 • 142 citations

Subtype 2 of angiotensin II receptors controls pressure-natriuresis in rats.

1995 • 138 citations

Angiotensin II AT2 receptors do not interact with guanine nucleotide binding proteins

1991 • 137 citations

The angiotensin AT₂ receptor modulates T‐type calcium current in non‐differentiated NG108‐15 cells

1992 • 130 citations

Isolation of two distinct type I angiotensin II receptor genes

1992 • 125 citations

A G Protein Is Involved in the Angiotensin AT2 Receptor Inhibition of the T-Type Calcium Current in Non-differentiated NG108-15 Cells

1995 • 124 citations

Sciatic nerve transection evokes lasting up-regulation of angiotensin AT2 and AT1 receptor mRNA in adult rat dorsal root ganglia and sciatic nerves

1998 • 121 citations

Characterization of angiotensin II receptor type 2 during differentiation and apoptosis of rat ovarian cultured granulosa cells

1995 • 113 citations

Angiotensin II Type 2 Receptor mRNA Expression in the Developing Cardiopulmonary System of the Rat

1996 • 110 citations

Renin-angiotensin system modulates renal bradykinin production

1996 • 110 citations

Activation of the de novo Biosynthesis of Sphingolipids Mediates Angiotensin II Type 2 Receptor-induced Apoptosis

1999 • 108 citations

Characterization of angiotensin II (AT2) binding sites in R3T3 cells.

1991 • 107 citations

Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth

1999 • 96 citations

Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)

1992 • 95 citations

Angiotensin peptides and inducible transcription factors

1999 • 95 citations

Angiotensin II Type 2 Receptor-Mediated Apoptosis of Cultured Neurons from Newborn Rat Brain**This work was supported by a grant from the NIH (NS-19441) and a postdoctoral fellowship (to U.V.S.) from the American Heart Association, Florida Affiliate.

1999 • 89 citations

AngiotensinII and NGF differentially influence microtubule proteins in PC12W cells: role of the AT2 receptor

1998 • 87 citations

Transient upregulation of the AT2 receptor mRNA level after global ischemia in the rat brain

1996 • 85 citations

Interferon Regulatory Factor-1 Up-regulates Angiotensin II Type 2 Receptor and Induces Apoptosis

1997 • 83 citations

Changes in skin angiotensin II receptors in rats during wound healing

1992 • 82 citations

Growth-Dependent Induction of Angiotensin II Type 2 Receptor in Rat Mesangial Cells

1997 • 79 citations

Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells

1993 • 76 citations

Developmental changes in angiotensin II receptor subtypes and AT1 receptor mRNA in rat kidney

1994 • 76 citations

Renal hemodynamic and excretory responses to PD 123319 and losartan, nonpeptide AT1 and AT2 subtype-specific angiotensin II ligands.

1992 • 74 citations

Long-term low-dose angiotensin converting enzyme inhibitor treatment increases vascular cyclic guanosine 3',5'-monophosphate.

1993 • 73 citations

AT₂ receptor stimulation induces generation of ceramides in PC12W cells

1999 • 69 citations

The Growth-dependent Expression of Angiotensin II Type 2 Receptor Is Regulated by Transcription Factors Interferon Regulatory Factor-1 and −2

1995 • 65 citations

Angiotensin AT2 receptor stimulates ERK1 and ERK2 in quiescent but inhibits ERK in NGF-stimulated PC12W cells

2000 • 65 citations

Inhibition of Cell Proliferation and Activation of Protein Tyrosine Phosphatase Mediated by Angiotensin II Type 2 (AT2) Receptor in R3T3 Cells

1996 • 64 citations

Insulin and Insulin‐Like Growth Factors Induce Expression of Angiotensin Type‐2 Receptor in Vascular‐Smooth‐Muscle Cells

1996 • 64 citations

Angiotensin II Activates the Na+/HCO3- Symport through a Phosphoinositide-independent Mechanism in Cardiac Cells

1995 • 57 citations

Regulation of Angiotensin II–induced Neuromodulation by MARCKS in Brain Neurons

1998 • 54 citations

The angiotensin AT2 receptor down-regulates neurofilament M in PC12W cells

1997 • 52 citations

Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II

1994 • 52 citations

Angiotensin receptors

1996 • 51 citations

Regulation of Angiotensin II Type 2 Receptor Gene by the Protein Kinase C–Calcium Pathway

1996 • 50 citations

Expression, Genomic Organization, and Transcription of the Mouse Angiotensin II Type 2 Receptor Gene

1995 • 48 citations

Peptide Growth Factors Markedly Decrease the Ligand Binding of Angiotensin II Type 2 Receptor in Rat Cultured Vascular Smooth Muscle Cells

1993 • 47 citations

ANGIOTENSIN II RECEPTORS AND RENIN IN THE PORCINE UTERUS: MYOMETRIAL AT₂ AND ENDOMETRIAL AT₁ RECEPTORS ARE DOWN‐REGULATED DURING GESTATION

1997 • 40 citations

Angiotensin II Type 2 Receptor-Mediated Apoptosis of Cultured Neurons from Newborn Rat Brain

1999 • 36 citations

Characterization of an angiotensin type-1 receptor partial cDNA from rat kidney: Evidence for a novel AT1B receptor subtype

1992 • 35 citations

Transcriptional Regulation of the Mouse Angiotensin II Type 2 Receptor Gene

1995 • 32 citations

Angiotensin AT2Receptor Degradation Is Prevented by Ligand Occupation

1998 • 31 citations

ANG II AT₁and AT₂receptors both inhibit bFGF-induced proliferation of bovine adrenocortical cells

1997 • 30 citations

Expression of a novel non-angiotensin II [125I]CGP 42112 binding site in healing wounds of the rat brain

1994 • 27 citations

Unopposed stimulation of the angiotensin AT2 receptor in the kidney

1998 • 23 citations

Linkage Mapping of the Angiotensin AT2Receptor Gene (Agtr2) to the Mouse X Chromosome

1995 • 18 citations

Repression of c- fos and c- jun gene expression is not part of AT 2 receptor coupled signal transduction

1998 • 18 citations