Allele specific Taqman-based real-time PCR assay to quantify circulating BRAFV600E mutated DNA in plasma of melanoma patients

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

2009 • 14,044 citations

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

High frequency of BRAF mutations in nevi

2002 • 1,701 citations

Circulating nucleic acids (CNAs) and cancer—A survey

2006 • 821 citations

The Raf/MEK/ERK pathway: new concepts of activation

2001 • 716 citations

Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases

1997 • 446 citations

Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation.

2003 • 432 citations

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

2003 • 327 citations

Incidence of BRAF Oncogene Mutation and Clinical Relevance for Primary Cutaneous Melanomas

2004 • 209 citations

Melanoma genetics and the development of rational therapeutics

2005 • 184 citations

High-Resolution Melting Analysis for Rapid Detection ofKRAS, BRAF,andPIK3CAGene Mutations in Colorectal Cancer

2008 • 165 citations

Utility of Circulating B-RAF DNA Mutation in Serum for Monitoring Melanoma Patients Receiving Biochemotherapy

2007 • 159 citations

Detection of Gene Amplification in Archival Breast Cancer Specimens by Laser-Assisted Microdissection and Quantitative Real-Time Polymerase Chain Reaction

2000 • 147 citations

BRAF somatic mutations in malignant melanoma and melanocytic naevi

2006 • 115 citations

Is the role of circulating DNA as a biomarker of cancer being prematurely overrated?

2009 • 103 citations

Detection of mutated KRAS2 sequences as tumor markers in plasma/serum of patients with gastrointestinal cancer.

2000 • 85 citations

Recent progress in understanding the pathology of malignant melanoma

2009 • 78 citations

Detection of mutated BRAFV600E variant in circulating DNA of stage III–IV melanoma patients

2007 • 75 citations

Clinical significance of BRAF mutations in metastatic melanoma.

2004 • 62 citations

High Sensitivity Scanning of Colorectal Tumors and Matched Plasma DNA for Mutations in APC, TP53, K‐RAS, and BRAF Genes with a Novel DHPLC Fluorescence Detection Platform

2004 • 56 citations

Therapeutic Strategies for Targeting BRAF in Human Cancer

2007 • 47 citations

Detection of Mutant BRAF Alleles in the Plasma of Patients with Metastatic Melanoma

2007 • 43 citations

Using genetics and genomics strategies to personalize therapy for cancer: Focus on melanoma

2010 • 35 citations

Selective Amplification of Rare Mutations Using Locked Nucleic Acid Oligonucleotides that Competitively Inhibit Primer Binding to Wild-Type DNA

2007 • 33 citations

Diagnostic potential of circulating nucleic acids for oncology

2003 • 26 citations

Molecular and genetic mechanisms in melanoma.

2008 • 24 citations

Mutant Form of BRAF Gene in Blood Plasma of Cancer Patients

2004 • 17 citations