Immunosuppressive agents in transplantation: Mechanisms of action and current anti-rejection strategies

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.

1975 • 1,605 citations

A Randomized Clinical Trial of OKT3 Monoclonal Antibody for Acute Rejection of Cadaveric Renal Transplants

1985 • 697 citations

LRISK FACTORS FOR CHRONIC REJECTION IN RENAL ALLOGRAFT RECIPIENTS

1993 • 684 citations

Human hand allograft: report on first 6 months

1999 • 684 citations

MYCOPHENOLATE MOFETIL IN RENAL ALLOGRAFT RECIPIENTS

1997 • 584 citations

A BLINDED, LONG-TERM, RANDOMIZED MULTICENTER STUDY OF MYCOPHENOLATE MOFETIL IN CADAVERIC RENAL TRANSPLANTATION

1998 • 403 citations

Successful Hand Transplantation — One-Year Follow-up

2000 • 403 citations

Immunosuppressive and other Effects of Mycophenolic Acid and an Ester Prodrug, Mycophenolate Mofetil

1993 • 388 citations

A Randomized Clinical Trial of Cyclosporine in Cadaveric Renal Transplantation

1986 • 295 citations

IMMUNOSUPPRESSIVE EFFECTS AND SAFETY OF A SIROLIMUS/CYCLOSPORINE COMBINATION REGIMEN FOR RENAL TRANSPLANTATION1

1998 • 293 citations

SIROLIMUS REDUCES THE INCIDENCE OF ACUTE REJECTION EPISODES DESPITE LOWER CYCLOSPORINE DOSES IN CAUCASIAN RECIPIENTS OF MISMATCHED PRIMARY RENAL ALLOGRAFTS: A PHASE II TRIAL1

1999 • 279 citations

The use of heterologous antilymphoid agents in canine renal and liver homotransplantation and in human renal homotransplantation.

1967 • 277 citations

VARIABLE ORAL ABSORPTION OF CYCLOSPORINE

1996 • 252 citations

CYCLOSPORINE PHARMACOKINETICS AND VARIABILITY FROM A MICROEMULSION FORMULATION—A MULTICENTER INVESTIGATION IN KIDNEY TRANSPLANT PATIENTS

1994 • 250 citations

Steroids, retinoids, and wound healing.

1998 • 215 citations

Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis.

1987 • 212 citations

Antiinflammatory steroid action: Basic and clinical aspects

1990 • 202 citations

FK506 and the role of immunophilins in nerve regeneration

1997 • 189 citations

The Effect of In Vivo T Helper and T Suppressor Lymphocyte Depletion on Wound Healing

1989 • 158 citations

PREDNISONE WITHDRAWAL 14 DAYS AFTER LIVER TRANSPLANTATION WITH MYCOPHENOLATE

1997 • 137 citations

Effects of cyclosporin, FK506, and rapamycin on graft-vessel disease

1991 • 133 citations

CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.

1994 • 132 citations

Seven Yearsʼ Experience with Antilymphoblast Globulin for Renal Transplantation From Cadaver Donors

1976 • 106 citations

COMPARISON OF TACROLIMUS WITH MICROEMULSION CYCLOSPORINE AS PRIMARY IMMUNOSUPPRESSION IN HEPATITIS C PATIENTS AFTER LIVER TRANSPLANTATION

1998 • 105 citations

Human Transplantation

1968 • 101 citations

Allogeneic vascularized transplantation of human femoral diaphyses and total knee joints—first clinical experiences

1998 • 99 citations

THE PHARMACOKINETICS OF A MICROEMULSION FORMULATION OF CYCLOSPORINE IN PRIMARY RENAL ALLOGRAFT RECIPIENTS1

1996 • 98 citations

INCIDENCE OF NEW-ONSET HYPERCHOLESTEROLEMIA IN RENAL TRANSPLANT PATIENTS TREATED WITH FK506 OR CYCLOSPORINE1

1998 • 89 citations

Randomized clinical trial of antithymocyte globulin in cadaver renal allograft recipients: importance of T cell monitoring.

1976 • 78 citations

Cyclosporin-A--present experimental status.

1981 • 77 citations

Mechanisms of glucocorticoid hormone action

1984 • 77 citations

The immunosuppressant FK506 increases GAP-43 mRNA levels in axotomized sensory neurons

1998 • 76 citations

Inhibition of the rejection of renal homografts in dogs by Burroughs Wellcome 57-322.

1961 • 76 citations

EVIDENCE FOR EARLIER STABILIZATION OF CYCLOSPORINE PHARMACOKINETICS IN DE NOVO RENAL TRANSPLANT PATIENTS RECEIVING A MICROEMULSION FORMULATION

1996 • 72 citations

IMPROVED LONG-TERM RESULTS WITH THYMOGLOBULINE INDUCTION THERAPY AFTER CARDIAC TRANSPLANTATION: A COMPARISON OF TWO DIFFERENT RABBIT-ANTITHYMOCYTE GLOBULINES

2000 • 64 citations

A 10-year experience with intravenous thymoglobuline in induction of immunosuppression following heart transplantation

1999 • 59 citations

A COMPARISON OF RABBIT ANTITHYMOCYTE SERUM ANE OKT3 AS PROPHYLAXIS AGAINST RENAL ALLOGRAFT REJECTION

1994 • 59 citations

USE OF ATG IN TREATMENT OF STEROID-RESISTANT REJECTION

1980 • 53 citations

New immunosuppressive drug combinations for mismatched related and cadaveric renal transplantation.

1986 • 48 citations

THE SAFETY AND TOLERABILITY OF CYCLOSPORINE EMULSION VERSUS CYCLOSPORINE IN A RANDOMIZED, DOUBLE-BLIND COMPARISON IN PRIMARY RENAL ALLOGRAFT RECIPIENTS1

1996 • 44 citations

INCREASED INCIDENCE OF INSULIN-DEPENDENT DIABETES MELLITUS IN PEDIATRIC RENAL TRANSPLANT PATIENTS RECEIVING TACROLIMUS (FK506)

1998 • 41 citations

Effects of a novel immunosuppressive agent, FK506, on human B cell activation

1990 • 39 citations

Comparative evaluation of tacrolimus (Fk506) and cyclosporin a as immunosuppressive agents

1995 • 39 citations

Immunosuppressive Drugs in Renal Transplantation

1992 • 34 citations

Cyclosporine, but not FK506, selectively induces renal and coronary artery smooth muscle contraction

1998 • 33 citations

Antithymocyte globulin in cadaver kidney transplantation: A randomized trial based on T-cell monitoring

1981 • 32 citations

Humanized, Nonmitogenic OKT3 Antibody, huOKT3γ(Ala-Ala): Initial Clinical Experience

1998 • 31 citations

Canadian clinical trial of antilymphocyte globulin in human cadaver renal transplantation.

1976 • 30 citations

ADMINISTRATION OF OKT3 AS A TWO-HOUR INFUSION ATTENUATES FIRST-DOSE SIDE EFFECTS1

1997 • 28 citations

Muromonab-Cd3 and Antithymocyte Globulin in Renal Transplantation

1997 • 24 citations

Tacrolimus vs Neoral in renal and renal/pancreas transplantation

1999 • 19 citations

Relationship of rabbit ATG serum clearance rate to circulating T-cell level, rejection onset, and survival in cardiac transplantation.

1977 • 18 citations

Tacrolimus and cyclosporine efficacy in high-risk kidney transplantation

1998 • 16 citations

Cyclosporine in cadaveric renal transplantation: five-year follow-up results of the European Multicentre Trial.

1988 • 13 citations

Reversal of acute renal allograft rejection with adjunctive AG therapy.

1981 • 12 citations

Conversion of renal transplant recipients from cyclosporin to low-dose tacrolimus for refractory rejection

1998 • 8 citations

Cadaver kidney transplantation in hyperimmunized patients.

1988 • 5 citations

Conversion of renal transplant recipients from cyclosporin to low-dose tacrolimus for refractory rejection

1998 • 4 citations

Selective Conversion from Azathioprine to Cyclosporin for Steroid-resistant Rejection in Renal Transplants: An Alternative Therapy

1989 • 2 citations