Coupling of muscarinic m1, m2 and m3 acetylcholine receptors, expressed in Chinese hamster ovary cells, to pertussis toxin-sensitive/insensitive guanine nucleotide-binding proteins

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

Muscarinic Receptors—Characterization, coupling and function

1993 • 1,264 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

1986 • 917 citations

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1988 • 792 citations

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

1987 • 766 citations

Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes

1988 • 669 citations

Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.

1989 • 627 citations

Primary Structure and Biochemical Properties of an M ₂ Muscarinic Receptor

1987 • 510 citations

Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

1984 • 498 citations

Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

1992 • 430 citations

An M2 Muscarinic Receptor Subtype Coupled to Both Adenylyl Cyclase and Phosphoinositide Turnover

1987 • 398 citations

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence

1986 • 344 citations

Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1.

1992 • 340 citations

Mammalian .beta.2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system

1984 • 249 citations

Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.

1986 • 233 citations

Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11.

1994 • 171 citations

Muscarinic acetylcholine receptor‐stimulated binding of guanosine 5′‐O‐(3‐thiotriphosphate) to guanine‐nucleotide‐binding proteins in cardiac membranes

1989 • 170 citations

Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.

1986 • 161 citations

Determinants of alpha 2-adrenergic receptor activation of G proteins: evidence for a precoupled receptor/G protein state.

1994 • 149 citations

Delineation of muscarinic receptor domains conferring selectivity of coupling to guanine nucleotide-binding proteins and second messengers.

1990 • 132 citations

Pharmacology characterization of guanine nucleotide exchange reactions in membranes from Cho cells stably transfected with human muscarinic receptors m1–m4

1993 • 121 citations

Functional reconstitution of purified muscarinic receptors and inhibitory guanine nucleotide regulatory protein

1985 • 119 citations

Subunit interactions of native and ADP-ribosylated alpha 39 and alpha 41, two guanine nucleotide-binding proteins from bovine cerebral cortex.

1986 • 116 citations

Pharmacology and second messenger interactions of cloned muscarinic receptors

1991 • 93 citations

Rat cardiac muscarinic receptors. I. Effects of guanine nucleotides on high- and low-affinity binding sites.

1982 • 90 citations

Transfected m2 muscarinic acetylcholine receptors couple to G alpha i2 and G alpha i3 in Chinese hamster ovary cells. Activation and desensitization of the phospholipase C signaling pathway.

1993 • 86 citations

Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.

1985 • 78 citations

Agonist-independent inhibition of G protein activation by muscarinic acetylcholine receptor antagonists in cardiac membranes

1992 • 72 citations

Chimeric m2/m3 muscarinic receptors: role of carboxyl terminal receptor domains in selectivity of ligand binding and coupling to phosphoinositide hydrolysis.

1990 • 64 citations

Na+ regulation of formyl peptide receptor-mediated signal transduction in HL 60 cells. Evidence that the cation prevents activation of the G-protein by unoccupied receptors

1989 • 57 citations

Pharmacological and Biochemical Characterization of Complexes of Muscarinic Acetylcholine Receptor and Guanine Nucleotide-Binding Protein

1989 • 49 citations

Role of GDP in formyl‐peptide‐receptor‐induced activation of guanine‐nucleotide‐binding proteins in membranes of HL 60 cells

1992 • 28 citations

Inhibition of catalytic unit of adenylate cyclase and activation of GTPase of N_i protein by βγ‐subunits of GTP‐binding proteins

1986 • 24 citations

Atropine dissociates complexes of muscarinic acetylcholine receptor and guanine nucleotide‐binding protein in heart membranes

1991 • 16 citations