In Vivo Measurement of Dopamine Receptors in Human Brain by Positron Emission Tomography Age and Sex Differencesa

Handbook of the Psychology of Aging

1978 • 1,980 citations

Positron Emission Tomography Reveals Elevated D ₂ Dopamine Receptors in Drug-Naive Schizophrenics

1986 • 935 citations

Imaging Dopamine Receptors in the Human Brain by Positron Tomography

1983 • 743 citations

Effects of Age on Dopamine and Serotonin Receptors Measured by Positron Tomography in the Living Human Brain

1984 • 701 citations

Human cerebral blood flow and oxygen consumption as related to aging

1956 • 332 citations

Central neurotransmitters and aging

1980 • 297 citations

Reduction in regional cerebral blood flow during normal aging in man.

1980 • 280 citations

Quantification of Neuroreceptors in the Living Human Brain. I. Irreversible Binding of Ligands

1986 • 279 citations

Effects of estrogen on the basal ganglia

1986 • 237 citations

Age‐Correlated Loss of Dopaminergic Binding Sites in Human Basal Ganglia

1982 • 212 citations

Reduced dopaminergic binding during aging in the rodent striatum

1980 • 197 citations

Spiperone: A ligand of choice for neuroleptic receptors

1978 • 178 citations

BILATERAL STUDIES OF CEREBRAL OXYGEN UPTAKE IN YOUNG AND AGED NORMAL SUBJECTS AND IN PATIENTS WITH ORGANIC DEMENTIA

1960 • 161 citations

Changes in the mechanisms of hormone and neurotransmitter action during aging: Current status of the role of receptor and post-receptor alterations. A review

1982 • 153 citations

Quantification of Neuroreceptors in the Living Human Brain. II. Inhibition Studies of Receptor Density and Affinity

1986 • 147 citations

Effect of age on adrenergic and dopaminergic receptor binding in rat brain

1980 • 144 citations

Evidence that D-1 dopamine receptors contribute to the supersensitive behavioral responses induced by L-dihydroxyphenylalanine in rats treated neonatally with 6-hydroxydopamine.

1985 • 140 citations

Dopamine receptor binding in vivo: The feasibility of autoradiographic studies

1978 • 136 citations

Relation of EEG to cerebral blood flow and metabolism in old age

1963 • 116 citations

Loss of rat striatal dopamine receptors with ageing is selective for D-2 but not D-1 sites: Association with increased non-specific binding of the D-1 ligand [3H]piflutixol

1984 • 115 citations

Neonatal-6-hydroxydopamine treatment: Model of susceptibility for self-mutilation in the lesch-nyhan syndrome

1984 • 107 citations

Evidence for loss of brain [3H]spiroperidol and [3H]ADTN binding sites in rabbit brain with aging

1980 • 104 citations

Effects of estrogens on the characteristics of [3H]spiroperidol and [3H]RU24213 binding in rat anterior pituitary gland and brain

1979 • 97 citations

Aging process affects a single class of dopamine receptors

1980 • 88 citations

Pre- and postsynaptic neurochemical alterations following estrogen-induced striatal dopamine hypo- and hypersensitivity

1983 • 84 citations

The demonstration in vivo of specific binding sites for neuroleptic drugs in mouse brain

1977 • 83 citations

Dopaminergic Changes in the Basal Ganglia A Generalized Phenomenon of Aging in Mammalsa

1988 • 76 citations

In vivo binding of 3H-pimozide in mouse striatum: Effects of dopamine agonists and antagonists

1977 • 76 citations

Effects of estrogen on striatal dopamine receptor function in male and female rats

1982 • 73 citations

Development of dopamine receptor denervation supersensitivity in the neostriatum of the senescent rat

1981 • 63 citations

Dopaminergic Receptors in the Rat Anterior Pituitary Change during the Estrous Cycle*

1982 • 62 citations

Estrogen inhibits the dopaminergic supersensitivity induced by neuroleptics

1982 • 62 citations

D-2 dopamine receptors in aging mouse striatum: determination of high- and low-affinity agonist binding sites.

1985 • 58 citations

Age-related regional loss of caudate-putamen dopamine receptors revealed by quantitative autoradiography

1986 • 57 citations

Comparison of the CNS effects induced by TRH and bicuculline after microinjection into medial septum, substantia nigra and inferior colliculus: Absence of support for a GABA antagonist action for TRH

1984 • 46 citations

Estrogen replacement and tardive dyskinesia

1985 • 44 citations

Neurotransmitter receptors in the central nervous system and aging: Pharmacological aspect (review)

1984 • 36 citations

Estradiol suppresses then enhances intracaudate dopamine-induced contralateral deviation

1982 • 35 citations

Modulation of brain and pituitary dopamine receptors by estrogens and prolactin

1985 • 35 citations

Effect of estrogens on dopamine autoreceptors in male rats

1983 • 29 citations

Prolactin and estradiol increase striatal dopamine receptor density in intact, castrated and hypophysectomized rats

1982 • 29 citations

Neurotransmitter Receptors and Aging

1984 • 22 citations

Age alters dopaminergic responses to estradiol

1982 • 19 citations

Neurochemistry of Dopamine in Huntington's Dementia and Normal Aging

1986 • 14 citations

Metabolism of the Brain a Measure of Cellular Function in Aging

1984 • 8 citations

Response : Human Brain Receptor Distribution

1986 • 5 citations