Molecular Determinants of High Affinity Phenylalkylamine Block of l-type Calcium Channels in Transmembrane Segment IIIS6 and the Pore Region of the α1Subunit

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Primary structure of the receptor for calcium channel blockers from skeletal muscle

1987 • 1,359 citations

Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

1993 • 614 citations

Sequence and Expression of mRNAs Encoding the α ₁ and α ₂ Subunits of a DHP-Sensitive Calcium Channel

1988 • 579 citations

Structural Basis of Amino Acid α Helix Propensity

1993 • 467 citations

MOLECULAR DETERMINANTS OF DRUG BINDING AND ACTION ON L-TYPE CALCIUM CHANNELS

1997 • 385 citations

Receptor sites for Ca2+ channel antagonists

1992 • 382 citations

Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS

1991 • 366 citations

Effect of Verapamil on the Sinoatrial and Atrioventricular Nodes of the Rabbit and the Mechanism by Which it Arrests Reentrant Atrioventricular Nodal Tachycardia

1974 • 285 citations

Ca2+ channels: diversity of form and function

1992 • 269 citations

Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane?

1982 • 254 citations

Panning transfected cells for electrophysiological studies.

1993 • 189 citations

Cloning and tissue‐specific expression of the brain calcium channel β‐subunit

1991 • 186 citations

The voltage- and time-dependent effects of (-)-verapamil on the slow inward current in isolated cat ventricular myocardium.

1978 • 176 citations

Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel

1993 • 173 citations

Identification of a phenylalkylamine binding region within the alpha 1 subunit of skeletal muscle Ca2+ channels.

1990 • 171 citations

Transfer of 1,4-Dihydropyridine Sensitivity from L-Type to Class A (BI) Calcium Channels

1996 • 151 citations

Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit.

1991 • 144 citations

Molecular Determinants of High Affinity Phenylalkylamine Block of L-type Calcium Channels

1995 • 136 citations

The IVS6 segment of the L-type calcium channel is critical for the action of dihydropyridines and phenylalkylamines.

1996 • 122 citations

Molecular Pharmacology of the Calcium Channel

1984 • 122 citations

Molecular Determinants of High Affinity Dihydropyridine Binding in L-type Calcium Channels

1996 • 118 citations

Calcium channel block and recovery from block in mammalian ventricular muscle treated with organic channel inhibitors

1982 • 112 citations

Analysis of the Dihydropyridine Receptor Site ofl-type Calcium Channels by Alanine-scanning Mutagenesis

1997 • 98 citations

Cat ventricular muscle treated with D600: characteristics of calcium channel block and unblock.

1984 • 95 citations

Two Amino Acid Residues in the IIIS5 Segment of L-Type Calcium Channels Differentially Contribute to 1,4-Dihydropyridine Sensitivity

1996 • 81 citations

Mechanism of K+ channel block by verapamil and related compounds in rat alveolar epithelial cells.

1995 • 65 citations

Cardiovascular protection by Ca antagonists

1980 • 61 citations

Transfer of L-type Calcium Channel IVS6 Segment Increases Phenylalkylamine Sensitivity of α1A

1996 • 51 citations

Distinct effects of mutations in transmembrane segment IVS6 on block of L-type calcium channels by structurally similar phenylalkylamines.

1996 • 51 citations

Molecular properties of a superfamily of plasma-membrane cation channels

1994 • 45 citations

Identification of Benz(othi)azepine-binding Regions within L-type Calcium Channel α1 Subunits

1996 • 43 citations

Studies on Voltage-operated Calcium Channels Using Radioligands

1983 • 13 citations