Perspectives: The role of changes in mechanical usage set points in the pathogenesis of osteoporosis

Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss.

1983 • 1,535 citations

Bone histomorphometry : techniques and interpretation

1983 • 1,154 citations

Skeletal structural adaptations to mechanical usage (SATMU): 1. Redefining Wolff's Law: The bone modeling problem

1990 • 938 citations

Humeral hypertrophy in response to exercise

1977 • 815 citations

The Mechanical Properties of Cortical Bone

1974 • 646 citations

Aging of bone tissue: mechanical properties.

1976 • 615 citations

The mechanostat: a proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents.

1987 • 608 citations

Normal and Pathological Remodeling of Human Trabecular Bone: Three Dimensional Reconstruction of the Remodeling Sequence in Normals and in Metabolic Bone Disease*

1986 • 596 citations

Biomechanics of Mammalian Terrestrial Locomotion

1990 • 558 citations

Aging of bone tissue

1976 • 537 citations

Mechanical loading history and skeletal biology

1987 • 510 citations

The influence of strain rate on adaptive bone remodelling

1982 • 474 citations

Skeletal structural adaptations to mechanical usage (SATMU): 2. Redefining Wolff's Law: The remodeling problem

1990 • 451 citations

Quantitative histological data on disuse osteoporosis

1974 • 435 citations

Physical Exercise as Prophylaxis against Involutional Vertebral Bone Loss: A Controlled Trial

1983 • 427 citations

The effect of prolonged physical training on the properties of long bone: a study of Wolff's Law.

1981 • 420 citations

Bone loss in response to long-term immobilisation

1978 • 385 citations

Functional strain as a determinant for bone remodeling

1984 • 381 citations

Vital biomechanics: Proposed general concepts for skeletal adaptations to mechanical usage

1988 • 354 citations

The effect of prolonged physical training on the properties of long bone

1981 • 333 citations

Histologic evidence for osteopenia and increased bone turnover in ovariectomized rats

1986 • 319 citations

Clinical Disorders of Bone and Mineral Metabolism

1983 • 307 citations

Bone histomorphometry

1994 • 306 citations

Osteopenia in the immobilized rat hind limb is associated with increased bone resorption and decreased bone formation

1989 • 286 citations

Structure, function and adaptation of compact bone

1990 • 282 citations

Clinical Disorders of Bone and Mineral Metabolism

1988 • 275 citations

Prostaglandin E2 enhances cortical bone mass and activates intracortical bone remodeling in intact and ovariectomized female rats

1990 • 256 citations

Consequences of the remodelling process for vertebral trabecular bone structure: a scanning electron microscopy study (uncoupling of unloaded structures)

1990 • 237 citations

Increased trabecular bone density due to bone-loading exercises in postmenopausal osteoporotic women

1987 • 223 citations

Adaptation of cancellous bone to aging and immobilization in the rat: A single photon absorptiometry and histomorphometry study

1990 • 218 citations

Cell and tissue biology a textbook of histology

1989 • 215 citations

Effect of long-term immobilisation on the pattern of bone loss in older dogs

1980 • 205 citations

Spinal mineral loss in oophorectomized women. Determination by quantitative computed tomography.

1980 • 205 citations

A comparison of iliac bone histomorphometric data in post-menopausal osteoporotic and normal subjects

1990 • 194 citations

A randomized study on the effects of estrogen/gestagen or high dose oral calcium on trabecular bone remodeling in postmenopausal osteoporosis

1989 • 194 citations

Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: I. Normal development

1989 • 172 citations

Reversibility of nontraumatic disuse osteoporosis during its active phase

1986 • 162 citations

Homeostatic control of bone structure: An application of feedback theory

1991 • 162 citations

The Pathomechanics of Osteoporoses

1985 • 148 citations

Histomorphometric analysis of dynamic parameters of trabecular bone formation in the iliac crest of Normal British subjects

1983 • 148 citations

Spinal Mineral Loss in Oophorectomized Women

1980 • 141 citations

Mean wall thickness and formation periods of trabecular bone packets in idiopathic osteoporosis

1981 • 133 citations

Skeletal change in response to altered strain environments: Is woven bone a response to elevated strain?

1989 • 131 citations

Skeletal structural adaptations to mechanical usage (SATMU): 3. The hyaline cartilage modeling problem

1990 • 126 citations

Adaptation of cancellous bone to overloading in the adult rat: A single photon absorptiometry and histomorphometry study

1990 • 126 citations

Expansion of the medullary cavity at the expense of cortex in postmenopausal osteoporosis

1984 • 124 citations

Effect of human parathyroid hormone (PTH(1-34)) on experimental osteopenia of rats induced by ovariectomy.

1988 • 118 citations

Effects of orally administered prostaglandin E-2 on cortical bone turnover in adult dogs: A histomorphometric study

1987 • 117 citations

Errors in bone remodeling: Toward a unified theory of metabolic bone disease

1989 • 116 citations

The pathogenesis of osteoporosis

1990 • 112 citations

Structural and mechanical adaptation of immature bone to strenuous exercise

1986 • 105 citations

Regulation of bone stress and strain in the immature and mature rat femur

1989 • 105 citations

Age-related changes in trabecular width and spacing in human iliac crest biopsies

1989 • 104 citations

Adaptation of diaphyseal structure with aging and increased mechanical usage in the adult rat: A histomorphometrical and biomechanical study

1991 • 100 citations

Preliminary observations of a form of coherence therapy for osteoporosis

1984 • 98 citations

Skeletal structural adaptations to mechanical usage (SATMU): 4. Mechanical influences on intact fibrous tissues

1990 • 98 citations

Ovariectomy and trabecular bone remodeling in the dog

1987 • 86 citations

Current Concepts of Bone Fragility

1986 • 83 citations

Estrogen-calcium interactions in the postmenopause: a quantitative description

1990 • 82 citations

Morphology and biochemistry of bone remodeling: possible control by vitamin D, parathyroid hormone, and other substances.

1988 • 71 citations

Bone Tissue Mechanisms Underlying Osteoporoses

1981 • 70 citations

The reversibility of disuse osteoporosis

1977 • 70 citations

Bone loss in the Beagle tibia: Influence of age, weight, and sex

1981 • 56 citations

Effects of simulated weightlessness on bone properties in rats

1990 • 49 citations

The Effects of Simulated Weightlessness on Bone Maturation*

1987 • 48 citations

Growth of Mouse Femurs during Continual Centrifugation

1960 • 34 citations

Changes in functional construction of bone in rats under conditions of simulated increased gravity

1973 • 32 citations

Normal postmenopausal women show iliac crest trabecular thickening on vertical sections

1989 • 32 citations

The ovariectomized, lactating rat as an experimental model for osteopenia: calcium metabolism and bone changes

1990 • 29 citations