Conformation of an enzyme-bound substrate of staphylococcal nuclease as determined by NMR

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

NMR with Proteins and Nucleic Acids

1986 • 7,896 citations

Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments

1954 • 6,078 citations

Investigation of exchange processes by two-dimensional NMR spectroscopy

1979 • 4,720 citations

Principles of Nucleic Acid Structure

2008 • 4,570 citations

Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins

1983 • 3,150 citations

Nuclear Magnetic Interactions in the HF Molecule

1956 • 664 citations

The Anatomy of A-, B-, and Z-DNA

1982 • 645 citations

Staphylococcal nuclease: Proposed mechanism of action based on structure of enzyme—thymidine 3′,5′-bisphosphate—calcium ion complex at 1.5-Å resolution

1979 • 375 citations

Catalytic Properties and Specificity of the Extracellular Nuclease of Staphylococcus aureus

1967 • 362 citations

Kinetic and Magnetic Resonance Studies of the Pyruvate Kinase Reaction

1966 • 277 citations

The crystal structure of the ternary complex of staphylococcal nuclease, Ca²⁺ and the inhibitor pdTp, refined at 1.65 Å

1989 • 258 citations

Residual structure in large fragments of staphylococcal nuclease: effects of amino acid substitutions

1989 • 234 citations

A Study of Manganous Complexes by Paramagnetic Resonance Absorption

1954 • 225 citations

Extreme conformational flexibility of the furanose ring in DNA and RNA

1978 • 209 citations

Studies of J-connectivities and selective 1H-1H Overhauser effects in H2O solutions of biological macromolecules by two-dimensional NMR experiments

1980 • 202 citations

Kinetic and magnetic resonance studies of active-site mutants of staphylococcal nuclease: factors contributing to catalysis

1987 • 168 citations

Staphylococcal nuclease: sequential assignments and solution structure

1989 • 132 citations

Distance measurement and structure refinement with NOE data

1990 • 130 citations

Kinetic and magnetic resonance studies of effects of genetic substitution of a calcium-liganding amino acid in staphylococcal nuclease

1986 • 122 citations

Staphylococcal nuclease reviewed: A prototypic study in contemporary enzymology. I isolation; physical and enzymatic properties

1978 • 119 citations

[15] Nuclear relaxation measurements of the geometry of enzyme-bound substrates and analogs

1978 • 115 citations

Analysis of Equilibrium Data from Proton Magnetic Relaxation Rates of Water for Manganese-Nucleotide-Kinase Ternary Complexes

1970 • 105 citations

Evaluation of quantitative affinity chromatography by comparison with kinetic and equilibrium dialysis methods for the analysis of nucleotide binding to staphylococcal nuclease

1975 • 97 citations

Site-directed mutants of staphylococcal nuclease. Detection and localization by proton NMR spectroscopy of conformational changes accompanying substitutions for glutamic acid-43

1987 • 92 citations

[29] Nuclear relaxation measurements of water protons and other ligands

1972 • 86 citations

Action of staphylococcal nuclease on synthetic substrates

1969 • 78 citations

The Binding of Nucleotides and Calcium to the Extracellular Nuclease of Staphylococcus aureus

1967 • 77 citations

Staphylococcal nuclease reviewed: A prototypic study in contemporary enzymology

1979 • 65 citations

Nuclear Overhauser effect studies of the conformations and binding site environments of deoxynucleoside triphosphate substrates bound to DNA polymerase I and its large fragment

1985 • 65 citations

Magnetic resonance studies of the conformation of enzyme-bound adenylyl(3' → 5')uridine and adenosine 5'-triphosphate on RNA polymerase from Escherichia coli

1977 • 59 citations

Quantitative small molecule NOESY. A practical guide for derivation of cross‐relaxation rates and internuclear distances

1989 • 53 citations

The Interaction of Nucleotides with the Active Site of Staphylococcal Nuclease

1967 • 50 citations

Electron spin echo modulation and nuclear relaxation studies of staphylococcal nuclease and its metal-coordinating mutants

1988 • 45 citations

Diverse interactions between the individual mutations in a double mutant at the active site of staphylococcal nuclease

1990 • 44 citations

Two-dimensional NMR studies of Staphylococcal nuclease. 1. Sequence-specific assignments of hydrogen-1 signals and solution structure of the nuclease H124L-thymidine 3',5'-bisphosphate-calcium ternary complex

1990 • 42 citations

Nuclear Overhauser effect studies of the conformations of tetraamminecobalt(III)-ATP free and bound to bovine heart protein kinase

1983 • 41 citations

The pH Dependence of the Steady State Kinetic Parameters for Staphylococcal Nuclease-catalyzed Hydrolysis of Deoxythymidine-3′-phosphate-5′-p-nitrophenylphosphate in H2O and D2O

1973 • 41 citations

Susceptibility of Dinucleotides Bearing Either 3'- or 5'-Monophosphate to Micrococcal Nuclease

1969 • 38 citations

Kinetic and magnetic resonance studies of the glutamate-43 to serine mutant of staphylococcal nuclease

1989 • 31 citations

[17] Ligand conformations and ligand-enzyme interactions as studied by the nuclear overhauser effect

1989 • 31 citations

Active Site Properties of [Aspartic acid 43]-Semisynthetic Nuclease-T′

1972 • 23 citations

Hydrolysis of ribo- and deoxyribo-dinucleotides by micrococcal nuclease

1970 • 8 citations