Synexin (annexin VII): A cytosolic calcium-binding protein which promotes membrane fusion and forms calcium channels in artificial bilayer and natural membranes

Multiple Calcium Channels and Neuronal Function

1987 • 1,336 citations

Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity

1986 • 671 citations

Aggregation of chromaffin granules by calpactin at micromolar levels of calcium

1988 • 443 citations

Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase

1986 • 421 citations

Identification and purification of an adrenal medullary protein (synexin) that causes calcium-dependent aggregation of isolated chromaffin granules.

1978 • 396 citations

Mechanism by which psychotropic drugs inhibit adenosine cyclic 3',5'-monophosphate phosphodiesterase of brain.

1976 • 389 citations

Calcium-dependent phospholipid- (and membrane-) binding proteins

1988 • 378 citations

Five distinct calcium and phospholipid binding proteins share homology with lipocortin I.

1988 • 364 citations

A role for calpactin in calcium-dependent exocytosis in adrenal chromaffin cells

1989 • 321 citations

The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats

1986 • 297 citations

cis-Unsaturated fatty acids induce the fusion of chromaffin granules aggregated by synexin.

1981 • 272 citations

Membrane Stabilization by Drugs: Tranquilizers, Steroids, and Anesthetics

1966 • 234 citations

I. Erythrocyte membrane stabilization by tranquilizers and antihistamines

1966 • 224 citations

Calcium-activated endonexin II forms calcium channels across acidic phospholipid bilayer membranes.

1990 • 213 citations

Two related but distinct forms of the Mr 36,000 tyrosine kinase substrate (calpactin) that interact with phospholipid and actin in a Ca2+-dependent manner.

1986 • 196 citations

Control of transmembrane lipid asymmetry in chromaffin granules by an ATP-dependent protein

1989 • 181 citations

Calcium channel activity of purified human synexin and structure of the human synexin gene.

1989 • 153 citations

Self-association of synexin in the presence of calcium. Correlation with synexin-induced membrane fusion and examination of the structure of synexin aggregates.

1979 • 145 citations

The amino acid sequence of protein II and its phosphorylation site for protein kinase C; the domain structure Ca2+-modulated lipid binding proteins.

1987 • 137 citations

Ca2+-activated synexin forms highly selective, voltage-gated Ca2+ channels in phosphatidylserine bilayer membranes.

1988 • 124 citations

Structural and functional characterization of endonexin II, a calcium- and phospholipid-binding protein.

1987 • 121 citations

Primary sequence of bovine calpactin I heavy chain (p36), a major cellular substrate for retroviral protein-tyrosine kinases: homology with the human phospholipase A2 inhibitor lipocortin

1986 • 119 citations

Role of synexin in membrane fusion. Enhancement of calcium-dependent fusion of phospholipid vesicles.

1981 • 114 citations

Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins.

1988 • 109 citations

Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein.

1988 • 98 citations

The Relationship Between Arachidonic Acid Release and Catecholamine Secretion from Cultured Bovine Adrenal Chromaffin Cells

1984 • 81 citations

Modulation of membrane fusion by calcium-binding proteins

1982 • 76 citations

Synexin facilitates fusion of specific phospholipid membranes at divalent cation concentrations found intracellularly.

1982 • 69 citations

Calcium-dependent Regulation of Chromaffin Granule Movement, Membrane Contact, and Fusion during Exocytosis

1982 • 60 citations

Inhibition of cell fusion by local anaesthetics and tranquillizers

1972 • 55 citations

A Molecular Basis for Synexin-Driven, Calcium-Dependent Membrane Fusion

1988 • 50 citations

Predicted structure for the calcium-dependent membrane-binding proteins p35, p36 and p32

1987 • 49 citations

Membrane capacity, measurements suggest a calcium‐dependent insertion of synexin into phosphatidylserine bilayers

1987 • 44 citations

A fluorescence assay for monitoring and analyzing fusion of biological membrane vesicles in vitro

1986 • 42 citations

Further Characterization of the Aggregation and Fusion of Chromaffin Granules by Synexin as a Model for Compound Exocytosis

1982 • 40 citations

Effect of synexin on aggregation and fusion of chromaffin granule ghosts at pH 6

1987 • 33 citations

Inhibition of synexin activity and exocytosis from chromaffin cells by phenothiazine drugs

1983 • 32 citations

Synexin and Chromaffin Granule Membrane Fusion A Novel “Hydrophobic Bridge” Hypothesis for the Driving and Directing of the Fusion Processa

1987 • 25 citations

Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets

1983 • 24 citations

Intragranular vesicles: new organelles in the secretory granules of adrenal chromaffin cells

1986 • 23 citations

Pattern of repeating aromatic residues in synexin. Similarity to the cytoplasmic domain of synaptophysin

1988 • 22 citations

Synexin binds in a calcium‐dependent fashion to oriented chromaffin cell plasma membranes

1985 • 21 citations

A Cell-free Model for Protein-Lipid Interactions in Exocytosis

1982 • 20 citations

Synexin, Calcium and the Hydrophobic Bridge Hypothesis for Membrane Fusion

1988 • 7 citations