Growth inhibition and apoptosis of myeloma cells by the CDK inhibitor flavopiridol

A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival

1975 • 3,051 citations

Antitumor Activity of Thalidomide in Refractory Multiple Myeloma

1999 • 2,565 citations

A PROSPECTIVE, RANDOMIZED TRIAL OF AUTOLOGOUS BONE MARROW TRANSPLANTATION AND CHEMOTHERAPY IN MULTIPLE MYELOMA

2013 • 2,176 citations

Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia

2000 • 897 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

Superiority of Tandem Autologous Transplantation Over Standard Therapy for Previously Untreated Multiple Myeloma

1997 • 576 citations

Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.

1996 • 535 citations

Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators

2000 • 501 citations

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

1996 • 477 citations

The Treatment of Multiple Myeloma

1994 • 409 citations

Flavopiridol Induces Apoptosis in Chronic Lymphocytic Leukemia Cells Via Activation of Caspase-3 Without Evidence of bcl-2 Modulation or Dependence on Functional p53

1998 • 290 citations

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia

2000 • 258 citations

Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol.

1999 • 255 citations

Flavopiridol Induces Apoptosis of Normal Lymphoid Cells, Causes Immunosuppression, and Has Potent Antitumor Activity In Vivo Against Human Leukemia and Lymphoma Xenografts

1998 • 246 citations

Early Induction of Apoptosis in Hematopoietic Cell Lines After Exposure to Flavopiridol

1998 • 225 citations

Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.

1994 • 219 citations

Flavopiridol, A Novel Cyclin-Dependent Kinase Inhibitor, in Metastatic Renal Cancer: A University of Chicago Phase II Consortium Study

2000 • 212 citations

The Novel Cyclin-Dependent Kinase Inhibitor Flavopiridol Downregulates Bcl-2 and Induces Growth Arrest and Apoptosis in Chronic B-Cell Leukemia Lines

1997 • 197 citations

Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells.

1996 • 190 citations

Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells.

1999 • 172 citations

Mcl‐1 and Bcl‐x_L are co‐regulated by IL‐6 in human myeloma cells

1999 • 157 citations

Relapse of multiple myeloma after autologous transplantation: survival after salvage therapy.

1995 • 91 citations

Flavopiridol metabolism in cancer patients is associated with the occurrence of diarrhea.

2000 • 78 citations

Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines.

1997 • 73 citations

In vitro evaluation of flavopiridol, a novel cell cycle inhibitor, in bladder cancer

1999 • 52 citations

Isolation and characterization of human multiple myeloma cell enriched populations

2000 • 46 citations

Ten‐year survival and prognostic factors in multiple myeloma

1994 • 35 citations

Advances in therapy of multiple myeloma: lessons from acute leukemia.

1997 • 15 citations