Staurosporine induces dissolution of microfilament bundles by a protein kinase C-independent pathway

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

1987 • 947 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.

1980 • 464 citations

Inhibition of protein kinase C by tamoxifen.

1985 • 464 citations

Down-regulation of protein kinase C is due to an increased rate of degradation

1987 • 442 citations

A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells.

1984 • 303 citations

Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP-dependent protein kinase and the myosin light chain kinase.

1988 • 279 citations

Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60.

1987 • 263 citations

Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action

1988 • 190 citations

Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.

1986 • 183 citations

Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C.

1988 • 148 citations

Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity.

1986 • 147 citations

The lipid binding, regulatory domain of protein kinase C. A 32-kDa fragment contains the calcium- and phosphatidylserine-dependent phorbol diester binding activity.

1986 • 140 citations

Effect of tamoxifen, a nonsteroidal antiestrogen, on phospholipid/calcium-dependent protein kinase and phosphorylation of its endogenous substrate proteins from the rat brain and ovary

1985 • 125 citations

Characterization of receptor tyrosine-specific protein kinases by the use of inhibitors. Staurosporine is a 100-times more potein inhibitor of insulin receptor than IGF-I receptor

1988 • 121 citations

Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells.

1988 • 121 citations

Pitfalls of immunogold labeling: analysis by light microscopy, transmission electron microscopy, and photoelectron microscopy.

1987 • 118 citations

Differences in phorbol-ester-induced down-regulation of protein kinase C between cell lines

1989 • 93 citations

Interaction of tumour promoters with epithelial cells in culture

1985 • 71 citations

Changes in fibroblast contractility, morphology, and adhesion in response to a phorbol ester tumor promoter

1988 • 70 citations

Formation of a phorbol ester-binding fragment from protein kinase C by proteolytic digestion.

1986 • 61 citations

Protein kinase C inhibitor H‐7 alters the actin cytoskeleton of cultured cells

1989 • 54 citations

Staurosporine, a potent protein kinase C inhibitor, fails to inhibit 12-O-tetradecanoylphorbol-13-acetate-caused ornithine decarboxylase induction in isolated mouse epidermal cells

1987 • 45 citations

Weak inhibition of protein kinase C coupled with various non-specific effects make sphingosine an unsuitable tool in platelet signal transduction studies

1989 • 27 citations

Photoelectron Imaging in Cell Biology

1985 • 25 citations

Astrocyte morphology altered by 1-(5-isoquinolinylsulfonyl) 2-methyl piperazine (H-7) and other protein kinase inhibitors

1989 • 20 citations

Differential effects of the diacylglycerol kinase inhibitor R59022 on thrombin versus collagen-induced human platelet secretion

1988 • 15 citations

Myosin light chain phosphorylation in fibroblast shape change, detachment and patching.

1986 • 14 citations

Effects of H-7 are not exclusively mediated through protein kinase C or the cyclic nucleotide-dependent kinases

1989 • 12 citations

Early phorbol ester induced release of cell surface fibronectin: direct observation by photoelectron microscopy.

1986 • 10 citations

Photoelectron microscopy

1985 • 9 citations

Immunophotoelectron Microscopy of the Cell Surface and Cytoskeleton^a

1986 • 8 citations