Mouse models of hypoxanthine phosphoribosyltransferase deficiency

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

A potential animal model for Lesch–Nyhan syndrome through introduction of HPRT mutations into mice

1987 • 487 citations

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

1989 • 423 citations

Biochemical Evidence of Dysfunction of Brain Neurotransmitters in the Lesch-Nyhan Syndrome

1981 • 370 citations

Apparent sprouting of striatal serotonergic terminals after dopamine-depleting brain lesions in neonatal rats

1984 • 230 citations

Lesch-Nyhan Syndrome: Rapid Detection of Heterozygotes by Use of Hair Follicles

1971 • 149 citations

Sprouting of striatal serotonin nerve terminals following selective lesions of nigro-striatal dopamine neurons in neonatal rat

1987 • 122 citations

Lesch‐nyhan syndrome: A study of motor behavior and cerebrospinal fluid neurotransmitters

1988 • 121 citations

Behavioral and neurochemical evaluation of a transgenic mouse model of Lesch-Nyhan syndrome

1988 • 108 citations

Lesch‐Nyhan syndrome

1985 • 77 citations

A dopamine deficiency model of Lesch-Nyhan disease—the neonatal-6-OHDA-lesioned rat

1990 • 74 citations

Monoamine deficiency in a transgenic (Hprt−) mouse model of Lesch-Nyhan syndrome

1989 • 61 citations

Expression of human HPRT in the central nervous system of transgenic mice

1985 • 56 citations

Animal models of Lesch-Nyhan syndrome

1990 • 49 citations

Lesch-Nyhan syndrome: Absence of the mutant enzyme in erythrocytes of a heterozygote for both normal and mutant hypoxanthine-guanine phosphoribosyl transferase

1972 • 47 citations

Amphetamine-induced behavioral phenotype in a hypoxanthine^guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome.

1991 • 43 citations

Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome.

1991 • 39 citations

Formation of Inosine-5'-Monophosphate by a Kinase in Cell-Free Extracts of Ehrlich Ascites Cells in Vitro

1968 • 33 citations

Antisense RNA production in transgenic mice

1990 • 33 citations

OBSERVATIONS ON PURINE METABOLISM IN RAT BRAIN

1969 • 28 citations

Inosine kinase in leucocytes of Lesch-Nyhan patients

1970 • 25 citations

Salvage of circulating hypoxanthine by tissues of the mouse

1983 • 23 citations

Hypoxanthine phosphoribosyl transferase deficiency, haematopoiesis and fertility in the mouse

1991 • 20 citations

Analysis of Forebrain Dopaminergic Pathways in HPRT — Mice

1991 • 13 citations

Purine Synthesis de novo and Salvage in Hypoxanthine Phosphoribosyltransferase-Deficient Mice

1990 • 7 citations