p16INK4a Gene Alterations Are Frequent in Lesions of Mycosis Fungoides

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Role of the p16 tumor suppressor gene in cancer.

1998 • 710 citations

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

1995 • 653 citations

Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia–lymphoma cells

1998 • 436 citations

Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies.

1997 • 420 citations

Cutaneous T cell lymphoma: Mycosis fungoides, Sézary syndrome, and other variants

1980 • 343 citations

The Tumor Suppressor Protein p16INK4a

1997 • 332 citations

p16INK4a Gene Inactivation by Deletions, Mutations, and Hypermethylation Is Associated With Transformed and Aggressive Variants of Non-Hodgkin's Lymphomas

1998 • 300 citations

Mycosis fungoides and Sezary syndrome [see comments]

1996 • 284 citations

Frequent Hypermethylation of p16 and p15 Genes in Multiple Myeloma

1997 • 195 citations

Homozygous Deletions at Chromosome 9p21 Involving p16 and p15 Are Associated With Histologic Progression in Follicle Center Lymphoma

1998 • 144 citations

Frequent Methylation Silencing of p15INK4b(MTS2) and p16INK4a (MTS1) in B-Cell and T-Cell Lymphomas

1999 • 137 citations

Loss of p16/INK4A Protein Expression in Non-Hodgkin's Lymphomas Is a Frequent Finding Associated with Tumor Progression

1998 • 125 citations

Deletions and rearrangement of CDKN2 in lymphoid malignancy

1995 • 113 citations

Loss of the cyclin-dependent kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies

1995 • 109 citations

Hypermethylation of a 5′ CpG island of p16 is a frequent event in non-Hodgkin’s lymphoma

1997 • 86 citations

Deletions of the cyclin-dependent kinase inhibitor genes p16INK4A and p15INK4B in non-Hodgkin's lymphomas

1995 • 68 citations

Overexpression of p53 Protein in Cutaneous T Cell Lymphoma: Relationship to Large Cell Transformation and Disease Progression

1998 • 62 citations

Codeletion of CDKN2 and MTAP genes in a subset of non-Hodgkin's lymphoma may be associated with histologic transformation from low-grade to diffuse large-cell lymphoma.

1998 • 52 citations

Codeletion ofCDKN2 andMTAP genes in a subset of non-Hodgkin's lymphoma may be associated with histologic transformation from low-grade to diffuse large-cell lymphoma

1998 • 47 citations

bcl-1, bcl-2, p53, c-myc, and lyt-10 Analysis in Cutaneous Lymphomas

1995 • 33 citations

Homozygous loss of the MTSl/pl6 and MTS2/pl5 genes in lymphoma and lymphoblastic leukaemia cell lines

1995 • 31 citations

p53 immunoreactivity is uncommon in primary cutaneous lymphoma

1995 • 27 citations

Reduced expression of CDKN2a/p16 INK4a in mycosis fungoides

1999 • 23 citations

p53 Oncoprotein Expression in Cutaneous Lymphoproliferations

1995 • 22 citations

CDKN2(MTS1/p16^INK4A) Gene Alterations in Adult T-Cell Leukemia/Lymphoma

1998 • 17 citations

CDKN2 (MTS1/p16^INK4A) Gene Alterations in Hematological Malignancies

1997 • 16 citations

Infrequent Expression of Protein p53 in Epidermotropic Variants of Cutaneous T‐Cell Lymphoma

1995 • 9 citations