Inhibition of crotoxin phospholipase A2 activity by manoalide associated with inactivation of crotoxin toxicity and dissociation of the heterodimeric neurotoxic complex

Tetanus toxin and botulinum toxins type A and B inhibit glutamate, gamma-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. Clues to the locus of action.

1992 • 301 citations

A sensitive and continuous fluorometric assay for phospholipase A2 using pyrene-labeled phospholipids in the presence of serum albumin

1989 • 241 citations

Identification and Properties of Very High Affinity Brain Membrane-binding Sites for a Neurotoxic Phospholipase from the Taipan Venom

1989 • 185 citations

Cobra venom phospholipase A2 inhibition by manoalide. A novel type of phospholipase inhibitor.

1985 • 156 citations

Crotoxin, a phospholipase A2 neurotoxin from the South American rattlesnake Crotalus durissus terrificus: purification of several isoforms and comparison of their molecular structure and of their biological activities

1988 • 148 citations

Relationship between catalysis and toxicological properties of three phospholipases A2 from elapid snake venoms

1981 • 81 citations

Crystal structure of bovine pancreatic phospholipase A2 covalently inhibited by p-bromo-phenacyl-bromide

1988 • 78 citations

Molecular Structure and Mechanism of Action of the Crotoxin Inhibitor from Crotalus durissus terrificus Serum

1995 • 73 citations

Inactivation of human synovial fluid phospholipase a2 by the marine natural product, manoalide

1990 • 73 citations

Regulation of Phospholipase A2 Enzymes: Selective Inhibitors and their Pharmacological Potential

1995 • 69 citations

Venom phospholipase A2 enzymes

1997 • 66 citations

Comparison of a relatively toxic phospholipase A2 from Naja nigricollis snake venom with that of a relatively non-toxic phospholipase A2 from Hemachatus haemachatus snake venom—II

1980 • 65 citations

In vitro inactivation of the neurotoxic action of β-bungarotoxin by the marine natural product, manoalide

1984 • 62 citations

Manoalide

1999 • 62 citations

Neurotoxins from the South American rattle snake venom.

1972 • 58 citations

SOME BIOCHEMICAL RESPONSES OF RAT SKELETAL MUSCLE TO A SINGLE SUBCUTANEOUS INJECTION OF A TOXIN (NOTEXIN) ISOLATED FROM THE VENOM OF THE AUSTRALIAN TIGER SNAKE NOTECHIS SCUTA TUS SCUTA TUS

1978 • 51 citations

Crocalbin: a new calcium‐binding protein that is also a binding protein for crotoxin, a neurotoxic phospholipase A₂

1999 • 49 citations

Catalytic activity and reactivity with p-bromophenacyl bromide of the phospholipase subunit of crotoxin. Influence of dimerization and association with the noncatalytic subunit.

1982 • 45 citations

Neurotoxic Phospholipases A₂ Ammodytoxin and Crotoxin Bind to Distinct High-Affinity Protein Acceptors in Torpedo marmorata Electric Organ

1997 • 45 citations

Specific binding of crotoxin to brain synaptosomes and synaptosomal membranes

1991 • 39 citations

Structure-Function Relationship of Phospholipase A₂From Snake Venoms

1994 • 36 citations

Immunochemical analysis of a snake venom phospholipase A2 neurotoxin, crotoxin, with monoclonal antibodies

1992 • 35 citations

Inactivation of phospholipase A2 by manoalide

1988 • 34 citations

Inhibition of venom phospholipases A2 by manoalide and manoalogue. Stoichiometry of incorporation.

1991 • 33 citations

Specific binding of three neurotoxins with phospholipase A2 activity to synaptosomal membrane preparations from the guinea pig brain

1986 • 33 citations

Identification of two specific lysines responsible for the inhibition of phospholipase A2 by manoalide

1995 • 27 citations

Secreted phospholipase A2-induced neurotoxicity and epileptic seizures after intracerebral administration: An unexplained heterogeneity as emphasized with paradoxin and crotoxin

1998 • 26 citations

Effects on Behaviour and EEG of Single Chain Phospholipases A₂ from Snake and Bee Venoms Injected into Rat Brain: Search for a Functional Antagonism

1996 • 25 citations

Purification and Partial Amino Acid Sequence of a Novel Protein of the Reticulocalbin Family

1997 • 21 citations

Binding proteins on synaptic membranes for crotoxin and taipoxin, two phospholipases A2 with neurotoxicity

1995 • 18 citations

Venom phospholipase A2-induced impairment of glutamate uptake: An indirect and nonselective effect related to phospholipid hydrolysis

1998 • 12 citations