Application of Automation to the Detection of Radiation Damage Using FISH Technology

The American Journal of Human Genetics

1950 • 5,048 citations

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

1988 • 1,334 citations

Cloning of human satellite III DNA: different components are on different chromosomes

1979 • 470 citations

Rapid Translocation Frequency Analysis in Humans Decades after Exposure to Ionizing Radiation

1992 • 435 citations

RADIATION PROTECTION DOSIMETRY

1969 • 392 citations

Current status of cytogenetic procedures to detect and quantify previous exposures to radiation

1988 • 360 citations

An analysis technique for biological shape. I

1974 • 219 citations

On fully automatic feature measurement for banded chromosome classification

1989 • 187 citations

Frequencies of X-ray-induced Chromosome Translocations in Human Peripheral Lymphocytes as Detected byin SituHybridization Using Chromosome-specific DNA Libraries

1992 • 162 citations

Validation of Chromosome Painting as a Biodosimeter in Human Peripheral Lymphocytes Following Acute Exposure to Ionizing Radiationin Vitro

1993 • 150 citations

Radiation-induced Chromosome Aberrations Analysed by Two-colour Fluorescencein SituHybridization with Composite Whole Chromosome-specific DNA Probes and a Pancentromeric DNA Probe

1993 • 146 citations

Chromosomal Aberrations in Human Lymphocytes Inducedin Vitroby Very Low Doses of X-rays

1992 • 142 citations

Rapid metaphase and interphase detection of radiation‐induced chromosome aberrations in human lymphocytes by chromosomal suppression in situ hybridization

1990 • 140 citations

Radiation-induced Chromosome Aberrations Analysed by Fluorescencein SituHybridization with a Triple Combination of Composite Whole Chromosome-specific DNA Probes

1992 • 131 citations

A cytogenetic follow-up study of the victims of a radiation accident in Goiania (Brazil)

1991 • 109 citations

Intelligent splitting in the chromosome domain

1989 • 105 citations

Submicroscopic deletions at the WAGR locus, revealed by nonradioactive in situ hybridization.

1992 • 96 citations

Using three-color chromosome painting to test chromosome aberration models.

1993 • 84 citations

Two-color hybridization with high complexity chromosome-specific probes and a degenerate alpha satellite probe DNA allows unambiguous discrimination between symmetrical and asymmetrical translocations

1991 • 82 citations

Analysis for DNA-proportional Distribution of Radiation-induced Chromosome Aberrations in Various Triple Combinations of Human Chromosomes Using Fluorescencein SituHybridization

1994 • 82 citations

Fully automatic chromosome segmentation

1994 • 82 citations

A Comparison of the Yields of Translocations and Dicentrics Measured Using Fluorescencein SituHybridization

1993 • 80 citations

Erosion and dilation of binary images by arbitrary structuring elements using interval coding

1989 • 77 citations

Frequency of Reciprocal Translocations and Dicentrics Induced in Human Blood Lymphocytes by X-irradiation as Determined by Fluorescencein SituHybridization

1993 • 57 citations

The use of fluorescence in situ hybridisation combined with premature chromosome condensation for the identification of chromosome damage

1991 • 47 citations

Chromosome Aberrations in Peripheral Lymphocytes and Radiation Dose to Active Bone Marrow in Patients Treated for Cancer of the Cervix

1989 • 36 citations

Radiation dosimetry by automatic image analysis of dicentric chromosomes

1991 • 34 citations

Structural Chromosome Analysis by Whole Chromosome Painting for Assessment of Radiation-Induced Genetic Damage

1992 • 23 citations

Automatic fluorescence metaphase finder speeds translocation scoring in FISH painted chromosomes

1994 • 23 citations

An Automated Chromosome Aberration Scoring System

1989 • 20 citations

Decomposition of Overlapping Chromosomes

1989 • 19 citations

Factors that Determine the in vivo Dose-Response Relationship for Stable Chromosome Aberrations in A-Bomb Survivors

1992 • 17 citations

A System for Fluorescence Metaphase Finding and Scoring of Chromosomal Translocations Visualized byin SituHybridization

1994 • 16 citations

Human Chromosome 'Painting' Probes Used to Measure Chromosome Translocations in Non-Human Primates: Extrapolations from Monkey to Man

1993 • 9 citations