Developing and Emerging Clinical Asthma Phenotypes

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

2013 • 3,338 citations

Asthma phenotypes: the evolution from clinical to molecular approaches

2012 • 2,168 citations

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

2012 • 2,003 citations

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

2014 • 1,943 citations

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

2009 • 1,922 citations

Cluster Analysis and Clinical Asthma Phenotypes

2008 • 1,858 citations

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

2009 • 1,797 citations

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial

2002 • 1,726 citations

Outdoor air pollution and asthma

2014 • 1,583 citations

Global asthma prevalence in adults: findings from the cross-sectional world health survey

2012 • 1,491 citations

Lebrikizumab Treatment in Adults with Asthma

2011 • 1,482 citations

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

2014 • 1,455 citations

Occupational Asthma

1991 • 1,416 citations

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

2009 • 1,320 citations

A 15-Year Follow-up Study of Ventilatory Function in Adults with Asthma

1998 • 1,266 citations

Mast-Cell Infiltration of Airway Smooth Muscle in Asthma

2002 • 1,219 citations

Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics

1999 • 1,198 citations

Overweight, Obesity, and Incident Asthma

2007 • 1,030 citations

Asthma: defining of the persistent adult phenotypes

2006 • 1,022 citations

Concentration and Size Distribution of Ultrafine Particles Near a Major Highway

2002 • 993 citations

Use of Exhaled Nitric Oxide Measurements to Guide Treatment in Chronic Asthma

2005 • 965 citations

Asthma prevalence, health care use, and mortality: United States, 2005-2009.

2011 • 901 citations

Inflammatory subtypes in asthma: Assessment and identification using induced sputum

2006 • 879 citations

Neutrophilic Inflammation in Severe Persistent Asthma

1999 • 850 citations

Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids

2002 • 812 citations

Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma.

1998 • 694 citations

CHRONIC COUGH: EOSINOPHILIC BRONCHITIS WITHOUT ASTHMA

1989 • 664 citations

Non-eosinophilic asthma: importance and possible mechanisms

2002 • 644 citations

The epidemiology of obesity and asthma

2005 • 624 citations

Chronic Cough as the Sole Presenting Manifestation of Bronchial Asthma

1979 • 617 citations

Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations

2006 • 601 citations

Effects of Maternal Smoking during Pregnancy and Environmental Tobacco Smoke on Asthma and Wheezing in Children

2001 • 582 citations

Distinguishing severe asthma phenotypes☆Role of age at onset and eosinophilic inflammation

2004 • 562 citations

An Official American Thoracic Society Clinical Practice Guideline: Exercise-induced Bronchoconstriction

2013 • 546 citations

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

2013 • 526 citations

Aspirin-induced asthma: Advances in pathogenesis, diagnosis, and management

2003 • 494 citations

Acute and chronic effects of cigarette smoking on exhaled nitric oxide.

1995 • 468 citations

Risk factors of frequent exacerbations in difficult-to-treat asthma

2005 • 467 citations

A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

2012 • 462 citations

Asthma

2013 • 455 citations

Smoking Affects Response to Inhaled Corticosteroids or Leukotriene Receptor Antagonists in Asthma

2007 • 428 citations

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes

2010 • 425 citations

Changes in Sputum Eosinophils Predict Loss of Asthma Control

2000 • 406 citations

Decline in Lung Function in the Busselton Health Study

2004 • 395 citations

Induced Sputum Cell Counts in Healthy Adults

2000 • 380 citations

Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years

2005 • 375 citations

Smoking and Airway Inflammation in Patients With Mild Asthma

2001 • 351 citations

Factors Associated with Persistent Airflow Limitation in Severe Asthma

2001 • 345 citations

Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

2014 • 329 citations

Short-Term Effects of PM ₁₀ and NO ₂ on Respiratory Health among Children with Asthma or Asthma-like Symptoms: A Systematic Review and Meta-Analysis

2009 • 327 citations

The relationship between obesity and asthma severity and control in adults

2008 • 319 citations

Evidence of Airway Inflammation and Remodeling in Ski Athletes with and without Bronchial Hyperresponsiveness to Methacholine

2000 • 317 citations

Living Near a Main Road and the Risk of Wheezing Illness in Children

2001 • 315 citations

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

2012 • 311 citations

The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma

2005 • 309 citations

Long-term exposure to close-proximity air pollution and asthma and allergies in urban children

2010 • 302 citations

Occupational Asthma

2014 • 301 citations

Effects of steroid therapy on inflammatory cell subtypes in asthma

2009 • 297 citations

Asthma outcomes: Exacerbations

2012 • 289 citations

Eosinophils in the Spotlight: Eosinophilic airway inflammation in nonallergic asthma

2013 • 289 citations

Prevalence of bronchial hyperresponsiveness and asthma in a rural adult population.

1987 • 288 citations

Occupational Asthma

1995 • 285 citations

Clinical phenotypes of asthma

2003 • 283 citations

Th17-mediated inflammation in asthma

2013 • 282 citations

Potentially Pathogenic Airway Bacteria and Neutrophilic Inflammation in Treatment Resistant Severe Asthma

2014 • 275 citations

A Multivariate Analysis of Risk Factors for the Air-Trapping Asthmatic Phenotype as Measured by Quantitative CT Analysis

2008 • 273 citations

Motor vehicle air pollution and asthma in children: A meta-analysis

2012 • 271 citations

Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data

2014 • 271 citations

Effect of smoke-free legislation on perinatal and child health: a systematic review and meta-analysis

2014 • 265 citations

Incidence of exercise-induced bronchospasm in Olympic winter sport athletes

2000 • 263 citations

Asthma caused by occupational exposures is common – A systematic analysis of estimates of the population-attributable fraction

2009 • 262 citations

Onset and Remission of Allergic Rhinitis and Asthma and the Relationship with Atopic Sensitization and Smoking

2000 • 262 citations

Increased Effects of Smoking and Obesity on Asthma among Female Canadians: The National Population Health Survey, 1994-1995

1999 • 254 citations

Acute respiratory health effects of air pollution on children with asthma in US inner cities

2008 • 251 citations

An Official American Thoracic Society Statement: Work-Exacerbated Asthma

2011 • 250 citations

Early-Life Air Pollution and Asthma Risk in Minority Children. The GALA II and SAGE II Studies

2013 • 246 citations

Cellular characteristics of sputum from patients with asthma and chronic bronchitis.

1989 • 244 citations

Maternal Smoking in Pregnancy and Asthma in Preschool Children

2012 • 241 citations

Parameters associated with persistent airflow obstruction in chronic severe asthma

2004 • 240 citations

Recurrent Exacerbations in Severe Asthma Are Associated with Enhanced Airway Closure During Stable Episodes

2000 • 236 citations

Asthma control, severity, and quality of life: Quantifying the effect of uncontrolled disease

2007 • 235 citations

Allergy and asthma in elite summer sport athletes

2000 • 221 citations

Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma

2013 • 220 citations

Induced Sputum Cellularity

2000 • 218 citations

“Refractory” Eosinophilic Airway Inflammation in Severe Asthma

2004 • 213 citations

Qualitative Analysis of High-Resolution CT Scans in Severe Asthma

2009 • 212 citations

Regular Smoking and Asthma Incidence in Adolescents

2006 • 208 citations

Full blood count parameters for the detection of asthma inflammatory phenotypes

2014 • 203 citations

Molecular and clinical rationale for therapeutic targeting of interleukin‐5 and its receptor

2011 • 203 citations

Cluster Analysis of Obesity and Asthma Phenotypes

2012 • 202 citations

Recent evidence for adverse effects of residential proximity to traffic sources on asthma

2007 • 202 citations

Severe adult-onset asthma: A distinct phenotype

2013 • 197 citations

Incidence and remission of asthma: A retrospective study on the natural history of asthma in Italy

2002 • 197 citations

Smoking cessation during pregnancy: A systematic literature review

2010 • 191 citations

Fraction of Exhaled Nitric Oxide at 50 mL/s

2007 • 188 citations

Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement

2014 • 187 citations

Blood Eosinophil Count Is a Useful Biomarker to Identify Patients with Severe Eosinophilic Asthma

2014 • 182 citations

Risk Factors for Growth and Decline of Lung Function in Asthmatic Individuals up to Age 42 years

1999 • 182 citations

Asthma and obesity

2012 • 181 citations

Influence of atopy on exhaled nitric oxide in patients with stable asthma and rhinitis

1999 • 181 citations

Risk Factors Associated With Persistent Airflow Limitation in Severe or Difficult-to-Treat Asthma

2007 • 179 citations

Asthma and the elite athlete: Summary of the International Olympic Committee's Consensus Conference, Lausanne, Switzerland, January 22-24, 2008

2008 • 177 citations

Airway inflammation in obese and nonobese patients with difficult‐to‐treat asthma

2008 • 174 citations

Traffic-related air pollution correlates with adult-onset asthma among never-smokers

2009 • 171 citations

A Prospective, Multicenter Survey on Causes of Chronic Cough in China

2012 • 167 citations

Prospective study of asthma in relation to smoking habits among 14,729 adults.

1988 • 165 citations

Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection

2001 • 160 citations

Chronic burden of near-roadway traffic pollution in 10 European cities (APHEKOM network)

2013 • 157 citations

Official American Thoracic Society Technical Standards: Spirometry in the Occupational Setting

2014 • 157 citations

Three phenotypes of adult‐onset asthma

2013 • 155 citations

Associations between ozone, PM2.5, and four pollen types on emergency department pediatric asthma events during the warm season in New Jersey: A case-crossover study

2014 • 153 citations

MITES AND HOUSE-DUST ALLERGY

1968 • 152 citations

Frequent exacerbators – a distinct phenotype of severe asthma

2013 • 151 citations

Occupational Exposure to Poultry Dust and Effects on the Respiratory System in Workers

2013 • 147 citations

Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects.

1996 • 142 citations

Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-up

2010 • 140 citations

Association between cleaning-related chemicals and work-related asthma and asthma symptoms among healthcare professionals

2011 • 140 citations

Body mass index trajectory classes and incident asthma in childhood: Results from 8 European Birth Cohorts—a Global Allergy and Asthma European Network initiative

2013 • 139 citations

Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes

2008 • 137 citations

Exhaled nitric oxide thresholds associated with a sputum eosinophil count >=3% in a cohort of unselected patients with asthma

2010 • 136 citations

Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthma

2005 • 132 citations

Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma

2013 • 131 citations

Interpretation of Positive Results of a Methacholine Inhalation Challenge and 1 Week of Inhaled Bronchodilator Use in Diagnosing and Treating Cough-Variant Asthma

1997 • 131 citations

The Influence of Age on Induced Sputum Differential Cell Counts in Normal Subjects

2004 • 128 citations

Early-life determinants of asthma from birth to age 20 years: A German birth cohort study

2014 • 123 citations

Occupational asthma

1997 • 122 citations

Cigarette smoking is associated with a greater risk of incident asthma in allergic rhinitis

2008 • 121 citations

Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease

2014 • 121 citations

The relationship between smoking and total immunoglobulin E levels

1982 • 120 citations

Obesity-Associated Severe Asthma Represents a Distinct Clinical Phenotype

2013 • 119 citations

Statistical Cluster Analysis of the British Thoracic Society Severe Refractory Asthma Registry: Clinical Outcomes and Phenotype Stability

2014 • 117 citations

Persistent Effects of Maternal Smoking during Pregnancy on Lung Function and Asthma in Adolescents

2013 • 114 citations

Effect of obesity on airway inflammation: a cross‐sectional analysis of body mass index and sputum cell counts

2007 • 109 citations

Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma

2002 • 107 citations

The socio‐economic burden of asthma is substantial in Europe

2007 • 102 citations

Passive Smoking

1981 • 101 citations

Effects of BMI, Fat Mass, and Lean Mass on Asthma in Childhood: A Mendelian Randomization Study

2014 • 101 citations

Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma

2014 • 98 citations

High Levels of Airborne Ultrafine and Fine Particulate Matter in Indoor Ice Arenas

2003 • 95 citations

The Impact of Cigarette Smoking on Asthma: A Population-Based International Cohort Study

2012 • 94 citations

Mechanisms of asthma in Olympic athletes – practical implications

2008 • 90 citations

Causes and Clinical Features of Subacute Cough

2006 • 90 citations

Airway inflammation, bronchial hyperresponsiveness and asthma in elite ice hockey players

2003 • 88 citations

Bronchial Challenges and Respiratory Symptoms in Elite Swimmers and Winter Sport Athletes

2010 • 86 citations

Chronic hyperplastic eosinophilic sinusitis as a predictor of aspirin-exacerbated respiratory disease

2005 • 85 citations

TENOR risk score predicts healthcare in adults with severe or difficult-to-treat asthma

2006 • 81 citations

Prevalence and Mechanisms of Development of Asthma and Airway Hyperresponsiveness in Athletes

2001 • 80 citations

Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study

2011 • 77 citations

Comparison of Peak Expiratory Flow Rate and FEV1 in Assessing Bronchomotor Tone after Challenges with Occupational Sensitizers

1991 • 76 citations

The Preventable Burden of Productivity Loss Due to Suboptimal Asthma Control

2014 • 75 citations

FEV1 decline in occupational asthma

2006 • 74 citations

Work-exacerbated asthma and occupational asthma: Do they really differ?

2012 • 68 citations

Modeling US Adult Obesity Trends: A System Dynamics Model for Estimating Energy Imbalance Gap

2014 • 68 citations

Risk factors associated with irreversible airflow limitation in asthma

2008 • 65 citations

Systems Medicine Approaches for the Definition of Complex Phenotypes in Chronic Diseases and Ageing. From Concept to Implementation and Policies

2014 • 61 citations

Airway Cells after Swimming Outdoors or in the Sea in Nonasthmatic Athletes

2003 • 59 citations

Effects of obesity and weight loss on airway physiology and inflammation in asthma

2012 • 55 citations

Investigation of Occupational Asthma

2009 • 55 citations

Non-invasive evaluation of lower airway inflammation in hyper-responsive elite cross-country skiers and asthmatics

1999 • 54 citations

Air Pollution and Prevalence of Bronchitic Symptoms Among Children in Taiwan

2010 • 52 citations

Relationship between airway neutrophilia and ageing in asthmatics and non‐asthmatics

2013 • 52 citations

Clinical Burden and Predictors of Asthma Exacerbations in Patients on Guideline-based Steps 4-6 Asthma Therapy in the TENOR Cohort

2014 • 51 citations

Chlamydophila (Chlamydia) pneumoniae serology and asthma in adults: A longitudinal analysis

2005 • 51 citations

Occupational asthma and occupational rhinitis: the united airways disease model revisited

2013 • 47 citations

Maternal smoking affects lung function and airway inflammation in young children with multiple-trigger wheeze

2013 • 47 citations

Effect of increased body mass index on asthma risk, impairment and response to asthma controller therapy in African Americans

2010 • 46 citations

Is there a role for macrolides in severe asthma?

2013 • 45 citations

Quantitative sputum cell counts as a marker of airway inflammation in clinical practice

2007 • 43 citations

Ozone Induces a Proinflammatory Response in Primary Human Bronchial Epithelial Cells through Mitogen-Activated Protein Kinase Activation Without Nuclear Factor-κB Activation

2014 • 39 citations

Predictors for the development of progressive severity in new-onset adult asthma

2014 • 38 citations

ASPIRIN ALLERGY: ITS RELATIONSHIP TO CHRONIC INTRACTABLE ASTHMA

1947 • 37 citations

Non‐atopic males with adult onset asthma are at risk of persistent airflow limitation

2012 • 37 citations

Prevalence and clinical features of cough variant asthma in a general internal medicine outpatient clinic in Japan

2005 • 36 citations

Effects of air pollution on lung function and symptoms of asthma, rhinitis and eczema in primary school children

2013 • 34 citations

Cough Due to Asthma and Nonasthmatic Eosinophilic Bronchitis

2009 • 30 citations

Non-invasive assessment of exhaled biomarkers in lung transplantation

2011 • 27 citations

Airway Inflammatory Responses Following Exposure to Occupational Agents

2011 • 25 citations

Perception of Bronchoconstriction Following Methacholine and Eucapnic Voluntary Hyperpnea Challenges in Elite Athletes

2013 • 25 citations

Cough and asthma

2006 • 22 citations

Challenges of treating asthma in people who smoke

2010 • 22 citations

Risk Factors, Predictors, and Markers for Work-related Asthma and Rhinitis

2010 • 16 citations

Sputum in asthma.

1987 • 13 citations

Smoking status and immunoglobulin E seropositivity to workplace allergens

2010 • 13 citations

Exhaled nitric oxide and screening for occupational asthma in two at-risk sectors: bakery and hairdressing

2014 • 12 citations

Fixed Airflow Obstruction among Nonsmokers with Asthma:A Case-Comparison Study

2013 • 7 citations

A Clinical Lecture on Asthma and its Treatment: Delivered at the Hospital for Consumption, Brompton

1898 • 2 citations