Effect of transition-state analogs on the redox properties of medium-chain acyl-CoA dehydrogenase

A nonlinear regression program for small computers

1981 • 563 citations

On the Existence of Spectrally Distinct Classes of Flavoprotein Semiquinones. A New Method for the Quantitative Production of Flavoprotein Semiquinones^*

1966 • 447 citations

An explanation for rapid enzyme-catalyzed proton abstraction from carbon acids: importance of late transition states in concerted mechanisms

1993 • 370 citations

Understanding the rates of certain enzyme-catalyzed reactions: Proton abstraction from carbon acids, acyl transfer reactions, and displacement reactions of phosphodiesters

1993 • 352 citations

The Reactivity of Flavoproteins with Sulfite

1969 • 342 citations

Chemistry and Biochemistry

1982 • 288 citations

Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate.

1993 • 238 citations

Understanding enzyme-catalyzed proton abstraction from carbon acids: details of stepwise mechanisms for .beta.-elimination reactions

1992 • 177 citations

Electrophilic catalysis can explain the unexpected acidity of carbon acids in enzyme-catalyzed reactions

1991 • 166 citations

Determination of glucose oxidase oxidation-reduction potentials and the oxygen reactivity of fully reduced and semiquinoid forms.

1978 • 159 citations

Acyl-coenzyme A dehydrogenase from pig kidney. Purification and properties

1979 • 139 citations

Mechanistic studies with general acyl-CoA dehydrogenase and butyryl-CoA dehydrogenase: evidence for the transfer of the .beta.-hydrogen to the flavin position N(5) as a hydride

1984 • 111 citations

An anaerobic spectroelectrochemical cell for studying the spectral and redox properties of flavoproteins

1980 • 107 citations

359. The phenazine series. Part VI. Reactions of alkyl phenazonium salts; the phenazyls

1937 • 94 citations

The reductive half-reaction in acyl-CoA dehydrogenase from pig kidney: studies with thiaoctanoyl-CoA and oxaoctanoyl-CoA analogues

1988 • 75 citations

Alternate electron acceptors for medium-chain acyl-CoA dehydrogenase: use of ferricenium salts

1990 • 74 citations

Regulation of the branched chain alpha-ketoacid pathway in liver.

1982 • 74 citations

2-Octynoyl coenzyme A is a mechanism-based inhibitor of pig kidney medium-chain acyl coenzyme A dehydrogenase: isolation of the target peptide

1988 • 70 citations

Inactivation of medium-chain acyl-CoA dehydrogenase by a metabolite of hypoglycin: characterization of the major turnover product and evidence suggesting an alternative flavin modification pathway

1993 • 69 citations

Interflavin oxidation-reduction reactions between pig kidney general acyl-CoA dehydrogenase and electron-transferring flavoprotein

1985 • 66 citations

Enzyme-activated inhibitors, alternate substrates, and a dead end inhibitor of the general acyl-CoA dehydrogenase.

1980 • 65 citations

Interaction of acyl coenzyme A substrates and analogs with pig kidney medium-chain acyl-CoA dehydrogenase

1987 • 58 citations

The critical micelle concentration of some physiologically important fatty acyl-coenzyme A's as a function of chain length

1986 • 58 citations

Reactivity of medium-chain acyl-CoA dehydrogenase toward molecular oxygen

1991 • 51 citations

Thermodynamic control of D-amino acid oxidase by benzoate binding.

1985 • 47 citations

Mutagenesis of the redox-active disulfide in mercuric ion reductase: catalysis by mutant enzymes restricted to flavin redox chemistry

1989 • 46 citations

Regulation of the redox potential of general acyl-CoA dehydrogenase by substrate binding

1990 • 42 citations

Redox potentials of the flavoprotein lactate oxidase

1983 • 41 citations

Selective inactivation of various acyl-CoA dehydrogenases by (methylenecyclopropyl)acetyl-CoA

1990 • 41 citations

Medium-chain acyl coenzyme A dehydrogenase from pig kidney has intrinsic enoyl coenzyme A hydratase activity

1986 • 33 citations

Lactate monooxygenase. III. Additive contributions of active site residues to catalytic efficiency and stabilization of an anionic transition state.

1994 • 29 citations

Studies of electron-transfer properties of salicylate hydroxylase from Pseudomonas cepacia and effects of salicylate and benzoate binding

1988 • 26 citations

Resonance Raman Study on Complexes of Medium-Chain Acyl-CoA Dehydrogenase1

1992 • 20 citations

Oxidation-reduction potentials of butyryl-CoA dehydrogenase

1986 • 19 citations

The reductive half-reaction in acyl-CoA oxidase from Candida tropicalis: Interaction with acyl-CoA analogues and an unusual thioesterase activity

1991 • 15 citations

Product Binding Modulates the Thermodynamic Properties of a Megasphaera elsdenii Short-Chain Acyl-CoA Dehydrogenase Active-Site Mutant

1994 • 15 citations

Influence of two substrate analogs on thermodynamic properties of medium-chain acyl-CoA dehydrogenase

1993 • 13 citations

Regulation of oxidation-reduction potentials of anthranilate hydroxylase from Trichosporon cutaneum by substrate and effector binding

1989 • 10 citations

13C- and 15N-NMR Studies on Medium-Chain Acyl-CoA Dehydrogenase Reconstituted with 13C- and 15N-Enriched Flavin Adenine Dinucleotide1

1993 • 10 citations

Introductory remarks

1988 • 8 citations