Reduced Central Serotonergic Activity in Mania: Implications for the Relationship between Depression and Mania

The Biochemistry of Affective Disorders

1967 • 1,183 citations

Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels

1971 • 1,006 citations

INTENSIFICATION OF THE CENTRAL SEROTONINERGIC PROCESSES AS A POSSIBLE DETERMINANT OF THE THYMOLEPTIC EFFECT

1969 • 705 citations

Serotonin and Behavior

1973 • 543 citations

Lithium in psychiatric therapy and prophylaxis

1968 • 496 citations

5-HYDROXYINDOLE COMPOUNDS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH PSYCHIATRIC OR NEUROLOGICAL DISEASES

1966 • 375 citations

POTENTIATION OF THE ANTIDEPRESSIVE EFFECT OF A MONOAMINE-OXIDASE INHIBITOR BY TRYPTOPHAN

1963 • 340 citations

Abnormalities of Indoleamines in Affective Disorders

1972 • 307 citations

CEREBRAL METABOLITES IN CEREBROSPINAL FLUID AS A BIOCHEMICAL APPROACH TO THE BRAIN

1970 • 284 citations

TRYPTOPHAN IN THE TREATMENT OF DEPRESSION

1967 • 274 citations

Compulsive Sexual Activity Induced by p -Chlorophenylalanine in Normal and Pinealectomized Male Rats

1969 • 255 citations

5-Hydroxyindoleacetic Acid Levels in the Cerebrospinal Fluid of Depressive Patients treated with Probenecid

1970 • 253 citations

Comparison of Lithium Carbonate and Chlorpromazine in the Treatment of Mania

1972 • 245 citations

Cerebrospinal Fluid Amine Metabolites in Affective Illness: The Probenecid Technique

1973 • 245 citations

ACID MONOAMINE METABOLITES OF CEREBROSPINAL FLUID IN MENTAL DEPRESSION AND MANIA

1966 • 215 citations

Cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in psychiatric patients

1969 • 213 citations

Lithium carbonate treatment in depression and mania

1969 • 210 citations

Biological Psychiatry

1973 • 205 citations

The effect of para-chlorophenylalanine on the sleep of cats

1968 • 196 citations

Inhibition of Serotonin Synthesis by Para-Chlorophenylalanine in Patients with the Carcinoid Syndrome

1967 • 191 citations

Concentrations of 5-hydroxyindolylacetic acid and homovanillic acid in the cerebrospinal fluid of the dog before and during treatment with probenecid

1966 • 189 citations

5-hydroxyindoleacetic acid (and homovanillic acid) levels in the cerebrospinal fluid after probenecid application in patiens with manic-depressive psychosis

1969 • 189 citations

Biogenic Amine Metabolites in Cerebrospinal Fluid of Depressed and Manic Patients

1972 • 178 citations

Lithium—Its Role in Psychiatric Research and Treatment

1974 • 170 citations

Potentiation of a monoamine oxidase inhibitor by tryptophan

1969 • 167 citations

POTENTIATION OF MONOAMINE-OXIDASE INHIBITORS BY TRYPTOPHAN

1963 • 162 citations

"Hypersexuality" and Behavioral Changes in Cats Caused by Administration of p -Chlorophenylalanine

1970 • 146 citations

Effect of tryptophan administration on 5HIAA in cerebrospinal fluid in man.

1970 • 136 citations

Amine metabolism in the human brain: Further evaluation of the probenecid test

1971 • 135 citations

A Controlled Study of the Antidepressant Effects of Lithium Carbonate

1972 • 134 citations

Insomnia following parachlorophenylalanin in the rat

1968 • 133 citations

The central metabolism of serotonin in the cat during insomnia. A neurophysiological and biochemical study after administration ofP-chlorophenylalanine or destruction of the raphe´system

1971 • 125 citations

Origin of 5-Hydroxyindoleacetic Acid in the Spinal Fluid

1971 • 122 citations

Brain Biogenic Amine Depletion and Mood

1974 • 120 citations

DEPRESSIVE ILLNESS: SOME RESEARCH STUDIES

1973 • 117 citations

Depression During Mania: Clinical Observations and Theoretical Implications

1972 • 117 citations

Sleep Patterns of the Monkey and Brain Serotonin Concentration: Effect of p -Chlorophenylalanine

1968 • 114 citations

DRUG‐INDUCED CHANGES IN THE CONCENTRATION OF 5‐OR INDOLYL COMPOUNDS IN CEREBROSPINAL FLUID AND CAUDATE NUCLEUS

1962 • 113 citations

Serotonin Now: Clinical Implications of Inhibiting Its Synthesis with Para-Chlorophenylalanine

1970 • 111 citations

COMPARISON OF 5‐HYDROXYINDOLES IN VARIOUS REGIONS OF DOG BRAIN AND CEREBROSPINAL FLUID

1968 • 108 citations

SEQUENTIAL COMPARISON OF L-TRYPTOPHAN WITH E.C.T. IN SEVERE DEPRESSION

1970 • 94 citations

THE PHARMACOLOGY AND BIOCHEMISTRY OF DEPRESSION.

1964 • 91 citations

Toward a Biology of Depression: Some Suggestions from Neurophysiology

1969 • 85 citations

Amine Metabolites in the Lumbar Cerebrospinal Fluid of Humans with Restricted Flow of Cerebrospinal Fluid

1971 • 82 citations

Clinical‐pharmacological evaluation of p‐chlorophenylalanine: A new serotonin‐depleting agent

1966 • 78 citations

Is cerebrospinal fluid the major avenue for the removal of 5-hydroxyindoleacetic acid from the brain?

1973 • 78 citations

Brain Chemistry and Mental Disease

1971 • 75 citations

The effect of parachlorophenylalanine on social interaction of male rats

1970 • 73 citations

L-Tryptophane and sleep

1971 • 66 citations

TRYPTOPHAN CONCENTRATION IN THE CEREBROSPINAL FLUID OF DEPRESSIVE PATIENTS

1972 • 61 citations

Tryptophan and Sleep in Young Adults

1972 • 59 citations

Tryptophan and an MAOI (Nialamide) in the Treatment of Depression

1971 • 59 citations

Effect of brain serotonin depletion on sleep in rats

1967 • 57 citations

PSYCHOLOGICAL RESPONSE TO CORTICOTROPIN, CORTISONE, AND RELATED STEROID SUBSTANCES

1952 • 56 citations

Depressive illness : some research studies

1972 • 55 citations

Methysergide in Mania

1968 • 54 citations

The Pharmacology of Imipramine and Related Antidepressants

1966 • 50 citations

THERAPEUTIC EFFECT OF PITUITARY ADRENOCORTICOTROPIC HORMONE (ACTH) IN A CASE OF HENOCH-SCHÖNLEIN VASCULAR (ANAPHYLACTOID) PURPURA

1950 • 49 citations

Lithium and Depression

1973 • 42 citations

SEROTONIN AND SLEEP IN THE CAT

1973 • 41 citations

Effects of chlorpromazine on the metabolism of catecholamines in dog brain

1969 • 41 citations

A pilot study of some kinetic aspects of the metabolism of 5-hydroxytryptamine in depressive patients.

1971 • 40 citations

Trial of Methysergide in Mania

1968 • 35 citations

SLEEP AND DEPRESSION. IV. LONGITUDINAL STUDIES

1971 • 30 citations

Longitudinal Sleep Study in Hypomania

1971 • 28 citations

BEHAVIORAL PHARMACOLOGY OF p-CHLOROPHENYLALANINE (PCPA)

1973 • 27 citations

CONTROL OF BRAIN 5-HT CONTENT BY DIETARY CARBOHYDRATES

1973 • 25 citations

RELATIONSHIP BETWEEN DEPRESSION AND MANIA

1971 • 21 citations

BEHAVIORAL AND METABOLIC EFFECTS OF L-TRYPTOPHAN IN UNIPOLAR DEPRESSED PATIENTS

1973 • 15 citations

The determination of 5-hydroxytryptamine in human urine

1969 • 14 citations

A DOUBLE‐BLIND INTENSIVE CROSSOVER DESIGN TRIAL OF METHYSERGIDE IN MANIA

1970 • 13 citations

A clinical trial of methysergide and lithium in mania

1969 • 13 citations

Lithium Carbonate as a Mood and Total Body Water Stabilizer

1970 • 13 citations

On the measurement of 5‐hydroxyindoleacetic acid in cerebrospinal fluid¹

1972 • 12 citations

BODY FLUID DISTRIBUTION IN MANIC AND DEPRESSED PATIENTS TREATED WITH LITHIUM CARBONATE *

1970 • 11 citations

Methysergide as a Treatment for Mania

1970 • 11 citations

Biochemical and Pharmacological Variations in Manic-Depressive Illness

1972 • 10 citations

A THERAPEUTIC TRIAL IN MIGRAINE WITH PARACHLOROPHENYLALANINE, A SPECIFIC SEROTONIN DEPLETOR

1970 • 5 citations