X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

1993 • 3,564 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

PENICILLIN-BINDING PROTEINS AND THE MECHANISM OF ACTION OF BETA-LACTAM ANTIBIOTICS

1983 • 698 citations

Resistance to Antibiotics Mediated by Target Alterations

1994 • 671 citations

Crystal orientation and X-ray pattern prediction routines for area-detector diffractometer systems in macromolecular crystallography

1987 • 396 citations

Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin‐resistant clinical isolates of Streptococcus pneumoniae

1991 • 280 citations

Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase.

1993 • 194 citations

A Covalent Enzyme-Substrate Intermediate with Saccharide Distortion in a Mutant T4 Lysozyme

1993 • 194 citations

Site-directed mutants, at position 166, of RTEM-1 beta-lactamase that form a stable acyl-enzyme intermediate with penicillin.

1991 • 137 citations

Structure of the peptide network of pneumococcal peptidoglycan.

1987 • 118 citations

The use of Sayre's equation with solvent flattening and histogram matching for phase extension and refinement of protein structures

1990 • 114 citations

Chapter 4 Utilization of lipid-linked precursors and the formation of peptidoglycan in the process of cell growth and division: membrane enzymes involved in the final steps of peptidoglycan synthesis and the mechanism of their regulation

1994 • 92 citations

The Refined Crystallographic Structure of aDD-Peptidase Penicillin-target Enzyme at 1.6 Å Resolution

1995 • 90 citations

Penicillin‐binding proteins in β‐lactam‐resistant laboratory mutants of Streptococcus pneumoniae

1987 • 77 citations

Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with β-lactams

1993 • 74 citations

Purification of Penicillin‐Binding Protein 3 from Streptococcus pneumoniae

1982 • 48 citations

Antibodies against the benzylpenicilloyl moiety as a probe for penicillin-binding proteins

1986 • 33 citations

Crystallization of a Genetically Engineered Water-soluble Primary Penicillin Target Enzyme

1993 • 10 citations