Physiologically based pharmacokinetic models for trichloroethylene and its oxidative metabolites.

A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans

1984 • 674 citations

The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver

1987 • 277 citations

Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice

1992 • 155 citations

Physiologically based pharmacokinetic modeling of the pregnant rat: A multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid

1989 • 126 citations

Consideration of the Target Organ Toxicity of Trichloroethylene in Terms of Metabolite Toxicity and Pharmacokinetics

1991 • 122 citations

A Human Physiologically Based Pharmacokinetic Model for Trichloroethylene and Its Metabolites, Trichloroacetic Acid and Free Trichloroethanol

1998 • 118 citations

Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods

1987 • 106 citations

Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: Examples with vinyl chloride and trichloroethylene

1995 • 103 citations

A Partition Coefficient Determination Method for Nonvolatile Chemicals in Biological Tissues

1994 • 100 citations

Trichloroethylene exposure. Simulation of uptake, excretion, and metabolism using a mathematical model.

1977 • 92 citations

Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite, trichloroacetic acid, in the rat and mouse

1991 • 86 citations

A Physiologically Based Pharmacokinetic Model for Trichloroethylene and Its Metabolites, Chloral Hydrate, Trichloroacetate, Dichloroacetate, Trichloroethanol, and Trichloroethanol Glucuronide in B6C3F1 Mice

1997 • 86 citations

Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: A multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid

1990 • 84 citations

MODELLING OF RESPIRATORY EXCHANGE OF POLAR SOLVENTS<xref ref-type="fn" rid="fn1"><sup>*</sup></xref>

1991 • 80 citations

Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE)

1993 • 79 citations

Absorption, excretion and metabolic fate of chloral hydrate and trichloroethanol.

1954 • 67 citations

Pharmacokinetic Modeling of Trichloroethylene and Trichloroacetic Acid in Humans

1993 • 62 citations

A pharmacokinetic model to study the excretion of trichloroethylene and its metabolites after an inhalation exposure.

1977 • 62 citations

Collection of a single alveolar exhaled breath for volatile organic compounds analysis

1995 • 59 citations

Potential of physiologically based pharmacokinetics to amalgamate kinetic data of trichloroethylene and tetrachloroethylene obtained in rats and man.

1989 • 55 citations

Conversion of Trichloroacetic Acid to Dichloroacetic Acid in Biological Samples

1996 • 51 citations

Pharmacokinetics for regulatory risk analysis: The case of trichloroethylene

1988 • 49 citations

Evaluating the Risk of Liver Cancer in Humans Exposed to Trichloroethylene Using Physiological Models

1993 • 45 citations

A Trichloroethylene Risk Assessment Using a Monte Carlo Analysis of Parameter Uncertainty in Conjunction with Physiologically‐Based Pharmacokinetic Modeling

1995 • 42 citations

Physiological pharmacokinetic modeling of inhaled trichloroethylene in rats

1991 • 41 citations

Physiologically Based Pharmacokinetic Modeling of Inhaled Trichloroethylene and Its Oxidative Metabolites in B6C3F1Mice

1999 • 37 citations

Trichloroethylene Cancer Risk: Simplified Calculation of PBPK-Based MCLs for Cytotoxic End Points

1997 • 31 citations

Simple method for rapid measurement of trichloroethylene and its major metabolites in biological samples

1999 • 28 citations

Pharmacokinetic analysis of chloral hydrate and its metabolism in B6C3F1 mice.

1996 • 28 citations

Combining Physiologically Based Pharmacokinetic Modeling with Monte Carlo Simulation to Derive an Acute Inhalation Guidance Value for Trichloroethylene

1997 • 25 citations

METABOLISM OF CHLORAL HYDRATE IN MICE AND RATS AFTER SINGLE AND MULTIPLE DOSES

1998 • 14 citations