Benzodiazepines and their antagonists: A pharmacoethological analysis with particular reference to effects on “aggression”

On aims and methods of Ethology

1963 • 4,190 citations

Selective antagonists of benzodiazepines

1981 • 1,235 citations

A Comparison of the Social Postures of Some Common Laboratory Rodents

1963 • 1,158 citations

The Rat: A Study in Behavior

1966 • 649 citations

Kinds of aggression and their physiological basis

1968 • 606 citations

Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.

1980 • 542 citations

Aggressive behavior in the rat

1977 • 540 citations

The Causes of Fighting in Mice and Rats

1951 • 465 citations

Brain mechanisms for offense, defense, and submission

1979 • 406 citations

Multidisciplinary approaches to aggression research

1981 • 360 citations

Benzodiazepine antagonist Ro 15-1788: Neurological and behavioral effects

1982 • 341 citations

Directed Attack Elicited from Hypothalamus

1962 • 330 citations

The benzodiazepines: from molecular biology to clinical practice

1984 • 293 citations

Sociobiology and Behavior.

1978 • 288 citations

Intraspecies aggression in rats: Effects of d-amphetamine and chlordiazepoxide

1974 • 263 citations

The anxiogenic action of benzodiazepine antagonists

1982 • 263 citations

Evidence for a late evolutionary appearance of brain-specific benzodiazepine receptors: an investigation of 18 vertebrate and 5 invertebrate species

1978 • 231 citations

CGS 8216: Receptor binding characteristics of a potent benzodiazepine antagonist

1982 • 192 citations

A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats

1970 • 190 citations

Conspecific aggression in the laboratory rat.

1975 • 173 citations

Behavioral effects of benzodiazepines: A review

1977 • 170 citations

Anxiogenic and non-anxiogenic benzodiazepine antagonists

1983 • 165 citations

Effects of drugs on the mouse-killing (muricide) test and its relationship to amygdaloid function

1966 • 156 citations

Precipitated Withdrawal by a Benzodiazepine Receptor Antagonist (Ro 15-1788) After 7 Days of Diazepam

1982 • 154 citations

Benzodiazepine Receptors in the Central Nervous System

1982 • 151 citations

Pharmacology of midazolam.

1981 • 150 citations

TIMID SINGLY‐HOUSED MICE: THEIR VALUE IN PREDICTION OF PSYCHOTROPIC ACTIVITY OF DRUGS

1975 • 144 citations

Social conflict activates status-dependent endogenous analgesic or hyperalgesic mechanisms in male mice: Effects of naloxone on nociception and behaviour

1983 • 128 citations

Alcohol and chlordiazepoxide increase suppressed aggression in mice

1980 • 122 citations

Drug Effects on Agonistic Behavior

1979 • 115 citations

The Benzodiazepines: From molecular biology to clinical practice

1983 • 112 citations

Comportement d'agressivit� intrasp�cifique induit par l'apomorphine chez le rat

1970 • 109 citations

Sociobiology and behavior

1983 • 107 citations

Advances in neuropsychopharmacology

1972 • 106 citations

Pharmacological and biochemical studies in isolation-induced fighting mice

1966 • 104 citations

EFFECTS OF DRUGS ON BEHAVIOUR OF AGGRESSIVE MICE

1979 • 102 citations

Social behaviour in rats and mice: An ethologically based model for differentiating psychoactive drugs

1982 • 98 citations

Effects of centrally active drugs on four models of experimentally-induced agreession in rodents

1969 • 97 citations

Treatment of “Minimal Brain Dysfunction” Syndromes: Selection of Drugs for Children with Hyperactivity and Learning Disabilities

1967 • 93 citations

Intrinsic actions of benzodiazepine antagonists

1982 • 93 citations

Differential Actions of Chlordiazepoxide and Oxazepam on Hostility

1968 • 91 citations

The effects of benzodiazepines on aggression: Reduced or increased?

1973 • 91 citations

The neuropharmacology of aggression: A critical review.

1974 • 79 citations

Behavioural Pharmacology

1989 • 73 citations

Methyl-β-carboline-induced convulsions are antagonized by Ro 15-1788 and by propyl-β-carboline

1982 • 71 citations

Quinolines and anxiety: Anxiogenic effects of CGS 8216 and partial anxiolytic profile of PK 9084

1983 • 69 citations

Blockade of 3-carbomethoxy-β-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216

1982 • 69 citations

Pharmacology of methaminodiazepoxide.

1960 • 69 citations

Drugs and stimulus-bound attack

1971 • 64 citations

Animal behaviour in the laboratory

1979 • 59 citations

Psychopharmacological aspects of aggression: A review of the literature and some new experiments

1969 • 59 citations

Drug Effects on Attack, Defense and Escape in Mice

1981 • 57 citations

Ethological analysis of drug action on aggression and defense

1983 • 54 citations

EFFECTS OF CHLORDIAZEPOXIDE (LIBRIUM) AND OTHER PSYCHOTROPIC AGENTS ON THE LIMBIC SYSTEM OF THE BRAIN

1962 • 53 citations

Pharmaco-Ethological Analysis of Social Behaviour of Isolated Mice

1981 • 48 citations

The effects of some psychotropic drugs on conditioned avoidance and aggressive behaviors

1966 • 47 citations

Behavioural examinations of the anti-aggressive drug Fluprazine

1983 • 46 citations

Antagonism of the anticonflict effects of chlordiazepoxide by ?-carboline carboxylic acid ethyl ester, Ro 15-1788 and ACTH(4?10)

1982 • 45 citations

Chlordiazepoxide and diazepam induced mouse killing by rats

1975 • 45 citations

Chlordiazepoxide and Hostility in Anxious Outpatients

1974 • 42 citations

Increased aggression among grouped male mice fed chlordiazepoxide

1970 • 42 citations

Inter-group aggression in mice

1975 • 40 citations

A New Chemical Structure with Specific Depressant Effects on the Amygdala and on the Hyper-irritability of the ‘Septal Rat’

1963 • 38 citations

Immediate Changes in Affect With Chlordiazepoxide

1965 • 38 citations

Patterns of brain monoamine activity and aggressive behavior

1978 • 38 citations

A possible olfactory component in the effects of diazepam on social behavior of mice

1982 • 37 citations

Specific benzodiazepine antagonist R015-1788 and thirst-induced drinking in the rat

1982 • 37 citations

Animal behaviour in the laboratory

1979 • 37 citations

A microcomputer technique for the detailed analysis of animal behaviour

1983 • 36 citations

Benzodiazepine receptors: are there endogenous ligands in the brain?

1981 • 36 citations

Psychotropic drugs and induced hostility.

1969 • 35 citations

CHLORDIAZEPOXIDE FOR CALMING ZOO ANIMALS

1961 • 34 citations

Evaluation of centrally acting drugs in mice with fighting behaviour induced by isolation

1962 • 32 citations

Evidence for intrinsic behavioural activity of the benzodiazepine antagonist, Ro15-1788, in male mice

1983 • 30 citations

Searching for endogenous ligand(s) of central benzodiazepine receptors

1983 • 29 citations

Social hierarchy in monkeys (Macaca mulatta) modified by chlordiazepoxide hydrochloride

1974 • 29 citations

Object Loss Prior to Medical Admissions in Japan

1969 • 28 citations

Drug effects on distress-evoked behavior in mice: Methodology and drug class comparisons

1971 • 27 citations

Toward a mechanism of the anti-aggression effects of chlordiazepoxide in rats

1974 • 26 citations

Chlordiazepoxide, expectation and hostility

1969 • 25 citations

Some studies on the influence of chlordiazepoxide on the social interaction of golden hamsters (Mesocricetus auratus)

1973 • 25 citations

Shock-elicited fighting and delta-9-tetrahydrocannabinol

1972 • 25 citations

Endogenous ligands for benzodiazepine receptors

1980 • 25 citations

Reversal of the anticonvulsant effects of diazepam on amygdaloid-kindled seizures by a specific benzodiazepine antagonist: RO 15-1788

1982 • 24 citations

Chlordiazepoxide (librium)-induced changes in intraspecific attack and selected non-agonistic behaviors in male siamese fighting fish

1975 • 24 citations

Effects of the benzodiazepine antagonist Ro15-1788 on social and agonistic behaviour in male albino mice

1984 • 22 citations

A note on the effects of some psychotropic drugs on the aggressive behaviour in the ant, Formica rufa

1966 • 21 citations

The effect of chlordiazepoxide on the hissing response elicited via hypothalamic stimulation

1964 • 18 citations

CHLORDIAZEPOXIDE FOR CALMING ZOO ANIMALS

1962 • 18 citations

Differentiation of classes of neurosedatives using rats with septal lesions

1966 • 17 citations

A microcomputer technique for the detailed behavioural, and automatic statistical, analysis of animal behaviour

1984 • 16 citations

[COMPARATIVE PHARMACOLOGICAL STUDY OF A NEW CENTRAL STIMULANT, 1-P-TOTYL-1-OXO-2-PYRROLIDINO-N-PENTANE HCL].

1963 • 15 citations

Behaviour of untreated mice to alcohol- or chlordiazepoxide-treated partners.

1971 • 15 citations

The pharmacology of prazepam. A new benzodiazepine derivative.

1970 • 14 citations

Convulsive and Anticonvulsive Properties of Neuro-Psycho-Pharmaca1

2015 • 14 citations

Despite various drugs, cats continue to kill mice

1978 • 12 citations

Pharmacological alteration of hyper-reactivity in rats with septal and hypothalamic lesions

1969 • 12 citations

The mechanism of anti-muricidal effects of chlordiazepoxide

1975 • 10 citations

Pharmacologic activity of a new class of agents which selectively inhibit aggressive behavior in rats.

1970 • 8 citations

Pharmacological properties of two chlordiazepoxide metabolites following microsomal enzyme inhibition.

1974 • 5 citations

The effects of drugs on the hyper-reactivity of rats with bilateral anterior hypothalamic lesions.

1969 • 4 citations

Instinctive Predatory Behavior of Mustelids (Mustela putorius f. furo, Mustela vlson f. dom.) Modified by Benzodiazepine Derivatives

1981 • 3 citations