Solid-phase synthesis of a focused library of trypanothione reductase inhibitors

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction

1981 • 1,044 citations

METABOLISM AND FUNCTIONS OF TRYPANOTHIONE IN THE KINETOPLASTIDA

1992 • 736 citations

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages

1997 • 293 citations

Radiofrequency Encoded Combinatorial Chemistry

1995 • 275 citations

Radio Frequency Tag Encoded Combinatorial Library Method for the Discovery of Tripeptide-Substituted Cinnamic Acid Inhibitors of the Protein Tyrosine Phosphatase PTP1B

1995 • 264 citations

Target-Based Drug Discovery for Malaria, Leishmaniasis, and Trypanosomiasis

2000 • 78 citations

Trypanothione as a Target in the Design of Antitrypanosomal and Antileishmanial Agents

2001 • 71 citations

Comparison of Resin and Solution Screening Methodologies in Combinatorial Chemistry and the Identification of a 100 nM Inhibitor of Trypanothione Reductase

1999 • 38 citations

Solid phase synthesis of polyamine conjugates for the study of trypanothione reductase

1997 • 33 citations