Direct evidence for the cooperative unfolding of cytochrome c in lipid membranes from H- 2 H exchange kinetics 1 1Edited by A. R. Fersht

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Primary structure effects on peptide group hydrogen exchange

1993 • 1,851 citations

Proton Transfer, Acid‐Base Catalysis, and Enzymatic Hydrolysis. Part I: ELEMENTARY PROCESSES

1964 • 1,743 citations

Hydrogen Exchange in Proteins

1966 • 1,115 citations

High-resolution three-dimensional structure of horse heart cytochrome c

1990 • 1,036 citations

Structural characterization of folding intermediates in cytochrome c by H-exchange labelling and proton NMR

1988 • 823 citations

Detection of Transient Protein Folding Populations by Mass Spectrometry

1993 • 547 citations

Conformational changes in proteins probed by hydrogen‐exchange electrospray‐ionization mass spectrometry

1991 • 449 citations

A 'molten-globule' membrane-insertion intermediate of the pore-forming domain of colicin A

1991 • 416 citations

Isotope effects in peptide group hydrogen exchange

1993 • 365 citations

Structural description of acid-denatured cytochrome c by hydrogen exchange and 2D NMR

1990 • 306 citations

Early steps in cytochrome c folding probed by time-resolved circular dichroism and fluorescence spectroscopy

1992 • 219 citations

[61] Cytochrome c from vertebrate and invertebrate sources

1967 • 211 citations

Membrane binding induces destabilization of cytochrome c structure

1991 • 198 citations

The structural motif of ß-lactoglobulin and retinol-binding protein: a basic framework for binding and transport of small hydrophobic molecules?

1988 • 191 citations

Diphosphatidylglycerol is required for optimal activity of beef heart cytochrome c oxidase.

1981 • 172 citations

Investigation of protein folding by mass spectrometry

1996 • 172 citations

Determinants of protein hydrogen exchange studied in equine cytochrome c

1998 • 172 citations

Structural and Kinetic Description of Cytochrome c Unfolding Induced by the Interaction with Lipid Vesicles

1997 • 139 citations

The structure of crystalline Escherichia coli-derived rat intestinal fatty acid-binding protein at 2.5-A resolution.

1988 • 137 citations

Amide proton exchange in proteins by EX1 kinetics: studies of the basic pancreatic trypsin inhibitor at variable p2H and temperature

1985 • 131 citations

Two-dimensional proton NMR studies of cytochrome c: hydrogen exchange in the N-terminal helix

1986 • 128 citations

Rendering a membrane protein soluble in water: a common packing motif in bacterial protein toxins

1993 • 125 citations

Reversible unfolding of cytochrome c upon interaction with cardiolipin bilayers. I. Evidence from deuterium NMR measurements

1991 • 125 citations

A Conformational Change in Cytochromecof Apoptotic and Necrotic Cells Is Detected by Monoclonal Antibody Binding and Mimicked by Association of the Native Antigen with Synthetic Phospholipid Vesicles

1999 • 117 citations

Binding of cytochrome c to liposomes as revealed by the quenching of fluorescence from pyrene-labeled phospholipids

1987 • 108 citations

Kinetics of the interaction of hemin liposomes with heme binding proteins

1984 • 99 citations

Interaction of cytochrome c and its precursor apocytochrome c with various phospholipids

1983 • 92 citations

Multiple Conformations of Physiological Membrane-Bound Cytochrome c

1998 • 91 citations

The role of cytochrome c diffusion in mitochondrial electron transport.

1988 • 88 citations

On the nature of the structural change of the colicin E1 channel peptide necessary for its translocation-competent state

1990 • 88 citations

A water-lipid interface induces a highly dynamic folded state in apocytochrome c and cytochrome c, which may represent a common folding intermediate

1992 • 87 citations

Defining Protein Ensembles with Native-state NH Exchange: Kinetics of Interconversion and Cooperative Units from Combined NMR and MS Analysis

1999 • 83 citations

Resolution of Individual Lipids in Mixed Phospholipid Membranes and Specific Lipid-Cytochrome c Interactions by Magic-Angle Spinning Solid-State Phosphorus-31 NMR

1994 • 80 citations

Lipid Specificity in the Interaction of Cytochrome c with Anionic Phospholipid Bilayers Revealed by Solid-State 31P NMR

1994 • 78 citations

Direct evidence for a two‐state protein unfolding transition from hydrogen‐deuterium exchange, mass spectrometry, and NMR

1996 • 71 citations

Conformational changes in cytochrome c and cytochrome oxidase upon complex formation: a resonance Raman study

1990 • 69 citations

The interaction of horse heart cytochrome c with phospholipid bilayers. Structural and dynamic effects

1994 • 62 citations

Characterization of Electrostatic and Nonelectrostatic Components of Protein−Membrane Binding Interactions

1996 • 51 citations

Protein folding intermediates with rapidly exchangeable amide protons contain authentic hydrogen-bonded secondary structures

1995 • 46 citations

Role of phospholipid in the low affinity reactions between cytochrome c and cytochrome oxidase

1983 • 35 citations

The pH dependence of hydrogen‐deuterium exchange in trp repressor: The exchange rate of amide protons in proteins reflects tertiary interactions, not only secondary structure

1996 • 13 citations