Subchronic effects of 2,3,7,8-TCDD or PCBs on thyroid hormone metabolism: use in risk assessment

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

1990 • 1,872 citations

Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment

1994 • 1,717 citations

Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene.

1974 • 1,562 citations

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450

1985 • 1,272 citations

Toxic equivalency factors for dioxin-like PCBs

1994 • 721 citations

High-resolution PCB analysis: synthesis and chromatographic properties of all 209 PCB congeners

1984 • 590 citations

Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans with human transthyretin

1993 • 374 citations

Enhanced luminescence procedure for sensitive determination of peroxidase-labelled conjugates in immunoassay

1983 • 343 citations

Binding of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin

1986 • 260 citations

Enhanced Thyroxine Metabolism and High Uptake Goiters in Rats After a Single Dose of 2,3,7,8- Tetrachlorodibenzo-p-Dioxin1¹

1977 • 201 citations

Interference of Polychlorinated Biphenyls in Hepatic and Brain Thyroid Hormone Metabolism in Fetal and Neonatal Rats

1993 • 193 citations

The effect of phenobarbital on the metabolism and excretion of thyroxine in rats

1989 • 189 citations

UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism

1992 • 172 citations

Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice. Co-segregation with aryl hydrocarbon (benzo(alpha)pyrene) hydroxylase induction.

1977 • 155 citations

Glucuronidation of thyroid hormone in rat liver: effects of in vivo treatment with microsomal enzyme inducers and in vitro assay conditions.

1993 • 137 citations

Effects of a Polychlorinated Biphenyl Mixture (Aroclor 1254) and DDT on Biliary Thyroxine Excretion in Rats¹

1974 • 134 citations

Thyroxine and 3,3′,5-Triiodothyronine Are Glucuronidated in Rat Liver by Different Uridine Diphosphate-Glucuronyltransferases*

1991 • 123 citations

Roles of UDP-Glucuronosyltransferases in Chemical Carcinogenesi

1991 • 117 citations

I131-LABELED l-THYROXINE

1952 • 104 citations

Reproductive and thyroid effects of low-level polychlorinated biphenyl (aroclor 1254) exposure1

1993 • 96 citations

Induction of drug-metabolizing enzymes by xenobiotics

1990 • 82 citations

Toxic Potency of 3,3′,4,4′,5-Pentachlorobiphenyl Relative to and in Combination with 2,3,7,8-Tetrachlorodibenzo-p-dioxin in a Subchronic Feeding Study in the Rat

1994 • 75 citations

Hepatic UDP-glucuronyltransferase(s) activity toward thyroid hormones in rats: Induction and effects on serum thyroid hormone levels following treatment with various enzyme inducers

1991 • 75 citations

Inhibition of Thyroid Hormone Transport in Plasma of Rats by Polychlorinated Biphenyls

1989 • 72 citations

Assessment of biological activities of mixtures of polychlorinated dibenzo-p-dioxins: Comparison between defined mixtures and their constituents

1991 • 71 citations

Ultrastructural and functional alterations of the rat thyroid gland produced by polychlorinated biphenyls compared with iodide excess and deficiency, and thyrotropin and thyroxine administration

1980 • 69 citations

In vitro AHH induction by polychlorinated biphenyl and dibenzofuran mixtures: Additive effects

1985 • 64 citations

Determination of microsomal UDP-glucuronyltransferase in needle-biopsy specimens of human liver

1978 • 62 citations

Glucuronidation of thyroid hormone by human bilirubin and phenol UDP‐glucuronyltransferase isoenzymes

1993 • 62 citations

Teratogenic effects of polychlorinated dibenzofurans in combination in mice

1987 • 61 citations

Subchronic Dose-Response Study of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Female Sprague-Dawley Rats

1995 • 56 citations

Subchronic toxicity of some chlorinated dibenzofurans (PCDFs) and a mixture of PCDFs and chlorinated dibenzodioxins (PCDDs) in rats

1988 • 53 citations

Glucuronidation of thyroid hormone in rat liver: effects of in vivo treatment with microsomal enzyme inducers and in vitro assay conditions

1993 • 52 citations

Effects of microsomal enzyme inducers upon UDP-glucuronic acid concentration and UDP-glucuronosyltransferase activity in the rat intestine and liver

1992 • 35 citations

THE EFFECT OF METHYLCHOLANTHRENE ON BILIARY THYROXINE EXCRETION IN NORMAL AND GUNN RATS

1973 • 35 citations

Toxic Potency of 2,3,3′,4,4′,5-Hexachlorobiphenyl Relative to and in Combination with 2,3,7,8-Tetrachlorodibenzo-p-dioxin in a Subchronic Feeding Study in the Rat

1994 • 30 citations

Interactive effects of 2,2′,4,4′,5,5′-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on thyroid hormone, vitamin A, and vitamin K metabolism in the rat

1992 • 25 citations

Interactions of 2,2′,4,4′,5,5′-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat

1992 • 24 citations

Interactive effects of PCDD's, PCDF's and PCB's as assessed by the E.L.S.-bioassay

1989 • 23 citations

Effects of thyroidectomy on the Ah receptor and enzyme inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat liver

1986 • 18 citations

Absence of interactions on hepatic retention and 7-ethoxyresorufin-O-deethylation activity after co-administration of 1,2,3,7,8-pentachlorodibenzo-p-dioxin and 2,4,5,2′,4′,5′-hexachlorobiphenyl

1992 • 12 citations