Genetic and related effects of Vinca rosea alkaloids

Chemical induction of sperm abnormalities in mice.

1975 • 871 citations

Detection of chemical mutagens by the dominant lethal assay in the mouse

1972 • 572 citations

THE VINCA ALKALOIDS: A NEW CLASS OF ONCOLYTIC AGENTS.

1963 • 558 citations

MICROTUBULAR CRYSTALS IN MAMMALIAN CELLS

1969 • 417 citations

The binding of vincristine, vinblastine and colchicine to tubulin

1972 • 273 citations

Vinblastine and Griseofulvin Reversibly Disrupt the Living Mitotic Spindle

1968 • 272 citations

Definition of three classes of binding sites in isolated microtubule crystals

1972 • 249 citations

Aggregation of microtubule subunit protein. Effects of divalent cations, colchicine, and vinblastine

1970 • 237 citations

Vinblastine-Induced Precipitation of Microtubule Protein

1969 • 205 citations

Ten model mutagens evaluated by the micronucleus test

1976 • 202 citations

Antitumor principles derived from Vinca rosea Linn. I. Vincaleukoblastine and leurosine.

1960 • 163 citations

Hematologic and Cytogenetic Remission of Blastic Transformation in Chronic Granulocytic Leukemia

1971 • 158 citations

The action of vincaleukoblastine on mitosis in vitro

1960 • 145 citations

Sister chromatid exchange studies for monitoring DNA damage and repair capacity after cytostatics in vitro and in lymphocytes of leukaemic patients under cytostatic therapy

1978 • 140 citations

Induction in vitro of Microtubular Crystals by Vinca Alkaloids

1969 • 137 citations

Effect of Vincristine on the Fine Structure of HeLa Cells During Mitosis<xref ref-type="fn" rid="FN2">2</xref>

1965 • 133 citations

THE STATHMOKINETIC EFFECT OF VINCRISTIME.

1964 • 116 citations

The effect of vincaleukoblastine on dividing cells in vivo.

1961 • 114 citations

Vinca Alkaloids. XI.¹ Structures of Leurocristine (LCR) and Vincaleukoblastine (VLB)²

1962 • 99 citations

Congenital Malformations in Hamster Embryos after Treatment with Vinblastine and Vincristine

1963 • 91 citations

Lymphocyte chromosome studies in humans exposed to chemical mutagens

1976 • 85 citations

Biochemical effects of the vinca alkaloids II. A comparison of the effects of colchicine, vinblastine and vincristine on the synthesis of ribonucleic acids in Ehrlich ascites carcinoma cells

1964 • 84 citations

Biological properties of Vincaleukoblastine, an alkaloid in Vinca rosea Linn, with reference to its antitumor action.

1960 • 83 citations

Vinblastine and microtubules

1971 • 82 citations

Teratology in the Macaca mulatta

1968 • 73 citations

Some biological effects of Vincaleukoblastine, an alkaloid in Vinca rosea Linn in patients with malignant disease.

1960 • 59 citations

Cytological and clinical observations during vincaleukoblastine therapy of disseminated cancer

1962 • 49 citations

Vinblastine Sulfate in Hodgkin's Disease in Pregnancy

1964 • 38 citations

Effect of the Vinca Alkaloids on RNA Synthesis in Human Cells in vitro

1968 • 37 citations

Cleft lip and jaw induced in fetal rats by vincristine.

1965 • 36 citations

Teratogenic effects of vincristine in three lines of mice

1969 • 33 citations

Delivery of a Normal Infant During the Course of Oral Vinblastine Sulfate Therapy for Hodgkin's Disease

1964 • 33 citations

Biochemical effects of the vinca alkaloids—I. effects of vinblastine on nucleic acid synthesis in mouse tumor cells

1964 • 31 citations

Comparative Effects of Colchicine and Vincaleukoblastine on Bone Marrow Mitotic Activity in Syrian Hamster.

1961 • 30 citations

Use of Vinblastine Sulfate to Treat Hodgkin's Disease During Pregnancy

1964 • 30 citations

The stathmokinetic effect of vincaleukoblastine on normal bone marrow and leukemic cells.

1961 • 29 citations

Cytotoxic effects of various pesticides in vivo and in vitro

1973 • 27 citations

Mitoseablaufst�rungen

1963 • 27 citations

Vinblastine Sulfate Treatment of Hodgkin's Disease during a Pregnancy

1964 • 24 citations

Treatment of leukemia, lymphoma, and other malignant neoplasms with Vinblastine.

1961 • 23 citations

[DISORDERS IN THE COURSE OF MITOSIS. III. ON THE EFFECT OF VINCALEUKOBLASTINE ON NORMAL AND MALIGNANT CELLS IN VITRO].

1963 • 22 citations

Vinblastine induces multipolar mitoses in tetraploid human cells

1970 • 19 citations

Vincristine induced malformations in the rat embryo.

1966 • 15 citations

Comparative studies of 14 mutagenic or carcinogenic substances in seven mutagenicity test systems (point mutation tests, cytogenetic test and the dominant lethal test)

1978 • 12 citations

Mitostatic action of vinblastine sulphate on oral epithelia of hamsters

1972 • 12 citations

Vinblastine Sulfate: Metaphase Arrest, Inhibition of RNA Synthesis, and Cytotoxicity in Novikoff Rat Hepatoma Cells<xref ref-type="fn" rid="FN2">2</xref>

1970 • 12 citations

Effects of vincristine on spermatogenesis studied by velocity sedimentation cell separation technique and serial mating.

1972 • 11 citations

Cytological effects of vinblastine in plants

1972 • 11 citations

L'action de la vincaleucoblastine sur la mitose chez Triturus helveticus Raz.

1964 • 11 citations

Perturbation of the generation cycle of human leukemic blast cells in vivo by vincristine.

1973 • 10 citations

Mutagenic effects of different mutagens on human chromosomes in vitro and in vivo as detected by conventional and “harlequin” methods

1978 • 10 citations

The effect of vinblastine sulfate on rat spermatogenesis.

1974 • 9 citations

IN VIVO EFFECTS OF VINBLASTINE AND PODOPHYLLIN ON DIVIDING CELLS OF DBA MOUSE FETUSES

1973 • 9 citations

Klinisch-pharmakologische, cytochemische und Feulgen-photometrische Untersuchungen bei unreifzelligen Erwachsenenleukosen unter kombinierter Chemotherapie mit Vincristin, Daunorubicin und Prednison

1970 • 8 citations

Effects of teratogenic doses of vincristine on mitotic cells in the fetuses of DBA mice

1969 • 8 citations

Vinblastine-induced chromosomal alterations in cultured chinese hamster cells

1969 • 8 citations

SELECTIVE INHIBITION OF EMBRYONIC DEOXYRIBONUCLEIC ACID SYNTHESIS BY VINBLASTINE

1970 • 7 citations

Sur l'effet multipolarisant de la vinblastine dans la division cellulaire d'Allium cepa L.

1975 • 6 citations

Interaction in vitro des acides nucléiques avec des alcaloïdes extraits de Vinca rosea et l'acide glutamique

1971 • 6 citations

Inhibition of reduction in female mouse meiosis

1969 • 6 citations

Search for mutagenic activity of the alkaloid vinblastine

1973 • 5 citations

Cytological and Autoradiographic Studies of the Effects of Vincaleukoblastine (VLB) on the Root Meristem Cells of <i>Vicia faba</i>

1973 • 5 citations

Selective effect of Vinca rosea L. alkaloids on type A4 rat spermatogonium*

2009 • 4 citations

The effect of vinblastine sulphate on the incorporation of [2-14C]glycine into housefly DNA

1972 • 3 citations

The nucleus anomaly test as a sensitive method of detecting mutagenic effects on somatic cells

1978 • 2 citations

Cytogenetic studies of patients suffering from leukemia and treated with "Velbe".

1974 • 1 citations